FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020415384> ?p ?o ?g. }

• W2020415384 endingPage "601" @default.
• W2020415384 startingPage "596" @default.
• W2020415384 abstract "Obesity is a risk factor for periodontitis, but the pathogenic mechanism involved is unclear. We studied the effects of insulin in periodontal tissues during the state of obesity-induced insulin resistance. Gingival samples were collected from fatty (ZF) and lean (ZL, control) Zucker rats. Endothelial nitric oxide synthase (eNOS) expression was decreased, and activities of protein kinase C (PKC) α, ß2, δ, and ϵ isoforms were significantly increased in the gingiva from ZF rats compared with those from ZL rats. Expression of oxidative stress markers (mRNA) and the p65 subunit of NF-κB was significantly increased in ZF rats. Immunohistochemistry revealed that NF-κB activation was also increased in the gingival endothelial cells from transgenic mice overexpressing NF-κB-dependent enhanced green fluorescent protein (GFP) and on a high-fat vs. normal chow diet. Analysis of the gingiva showed that insulin-induced phosphorylation of IRS-1, Akt, and eNOS was significantly decreased in ZF rats, but Erk1/2 activation was not affected. General PKC inhibitor and an anti-oxidant normalized the action of insulin on Akt and eNOS activation in the gingiva from ZF rats. This provided the first documentation of obesity-induced insulin resistance in the gingiva. Analysis of our data suggested that PKC activation and oxidative stress may selectively inhibit insulin-induced Akt and eNOS activation, causing endothelial dysfunction and inflammation." @default.
• W2020415384 created "2016-06-24" @default.
• W2020415384 creator A5004271518 @default.
• W2020415384 creator A5009528569 @default.
• W2020415384 creator A5023400964 @default.
• W2020415384 creator A5051021923 @default.
• W2020415384 creator A5075611620 @default.
• W2020415384 date "2014-04-17" @default.
• W2020415384 modified "2023-10-18" @default.
• W2020415384 title "Obesity-associated Gingival Vascular Inflammation and Insulin Resistance" @default.
• W2020415384 cites W1911775654 @default.
• W2020415384 cites W2008167069 @default.
• W2020415384 cites W2009337306 @default.
• W2020415384 cites W2020706170 @default.
• W2020415384 cites W2040509393 @default.
• W2020415384 cites W2044321665 @default.
• W2020415384 cites W2047283836 @default.
• W2020415384 cites W2049162521 @default.
• W2020415384 cites W2055168506 @default.
• W2020415384 cites W2059843925 @default.
• W2020415384 cites W2070428303 @default.
• W2020415384 cites W2071823872 @default.
• W2020415384 cites W2080823871 @default.
• W2020415384 cites W2082502030 @default.
• W2020415384 cites W2098596446 @default.
• W2020415384 cites W2108199395 @default.
• W2020415384 cites W2109168147 @default.
• W2020415384 cites W2109607186 @default.
• W2020415384 cites W2137136889 @default.
• W2020415384 cites W2142730314 @default.
• W2020415384 cites W2144408457 @default.
• W2020415384 cites W2145609732 @default.
• W2020415384 cites W2153479034 @default.
• W2020415384 cites W4246319509 @default.
• W2020415384 doi "https://doi.org/10.1177/0022034514532102" @default.
• W2020415384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4023466" @default.
• W2020415384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24744283" @default.
• W2020415384 hasPublicationYear "2014" @default.
• W2020415384 type Work @default.
• W2020415384 sameAs 2020415384 @default.
• W2020415384 citedByCount "36" @default.
• W2020415384 countsByYear W20204153842014 @default.
• W2020415384 countsByYear W20204153842015 @default.
• W2020415384 countsByYear W20204153842016 @default.
• W2020415384 countsByYear W20204153842017 @default.
• W2020415384 countsByYear W20204153842018 @default.
• W2020415384 countsByYear W20204153842019 @default.
• W2020415384 countsByYear W20204153842020 @default.
• W2020415384 countsByYear W20204153842021 @default.
• W2020415384 countsByYear W20204153842022 @default.
• W2020415384 countsByYear W20204153842023 @default.
• W2020415384 crossrefType "journal-article" @default.
• W2020415384 hasAuthorship W2020415384A5004271518 @default.
• W2020415384 hasAuthorship W2020415384A5009528569 @default.
• W2020415384 hasAuthorship W2020415384A5023400964 @default.
• W2020415384 hasAuthorship W2020415384A5051021923 @default.
• W2020415384 hasAuthorship W2020415384A5075611620 @default.
• W2020415384 hasBestOaLocation W20204153842 @default.
• W2020415384 hasConcept C11960822 @default.
• W2020415384 hasConcept C126322002 @default.
• W2020415384 hasConcept C134018914 @default.
• W2020415384 hasConcept C185592680 @default.
• W2020415384 hasConcept C2776151105 @default.
• W2020415384 hasConcept C2776914184 @default.
• W2020415384 hasConcept C2777391703 @default.
• W2020415384 hasConcept C2777622882 @default.
• W2020415384 hasConcept C2778326061 @default.
• W2020415384 hasConcept C2779306644 @default.
• W2020415384 hasConcept C2780972559 @default.
• W2020415384 hasConcept C519581460 @default.
• W2020415384 hasConcept C55493867 @default.
• W2020415384 hasConcept C71924100 @default.
• W2020415384 hasConcept C75217442 @default.
• W2020415384 hasConceptScore W2020415384C11960822 @default.
• W2020415384 hasConceptScore W2020415384C126322002 @default.
• W2020415384 hasConceptScore W2020415384C134018914 @default.
• W2020415384 hasConceptScore W2020415384C185592680 @default.
• W2020415384 hasConceptScore W2020415384C2776151105 @default.
• W2020415384 hasConceptScore W2020415384C2776914184 @default.
• W2020415384 hasConceptScore W2020415384C2777391703 @default.
• W2020415384 hasConceptScore W2020415384C2777622882 @default.
• W2020415384 hasConceptScore W2020415384C2778326061 @default.
• W2020415384 hasConceptScore W2020415384C2779306644 @default.
• W2020415384 hasConceptScore W2020415384C2780972559 @default.
• W2020415384 hasConceptScore W2020415384C519581460 @default.
• W2020415384 hasConceptScore W2020415384C55493867 @default.
• W2020415384 hasConceptScore W2020415384C71924100 @default.
• W2020415384 hasConceptScore W2020415384C75217442 @default.
• W2020415384 hasIssue "6" @default.
• W2020415384 hasLocation W20204153841 @default.
• W2020415384 hasLocation W20204153842 @default.
• W2020415384 hasLocation W20204153843 @default.
• W2020415384 hasLocation W20204153844 @default.
• W2020415384 hasOpenAccess W2020415384 @default.
• W2020415384 hasPrimaryLocation W20204153841 @default.
• W2020415384 hasRelatedWork W138803513 @default.
• W2020415384 hasRelatedWork W1983641721 @default.
• W2020415384 hasRelatedWork W1986132654 @default.

• next