Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020418092> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2020418092 endingPage "586" @default.
- W2020418092 startingPage "575" @default.
- W2020418092 abstract "p330d/CENP-F is a novel proliferation-associated and cell cycle-dependent centromere autoantigen which appears to play a very important role in mitotic progression. As an initial step in exploring the clinical and biological significance of autoantibodies to this protein, we evaluated the clinical histories of 26 patients producing these antibodies. The antibodies were detected by both indirect immunofluorescence microscopy (HF) and Western blotting. All the sera contained anti-p330d/CENP-F IgG antibodies, with an average titer by HF of 1:6,917 (range 1:160 to 1:20,480). Most of the patients had disorders associated with abnormal or increased cell proliferation at the time the anti-p330d/CENP-F antibodies were detected. These included cancers of various types (14), chronic liver disease (3), chronic rejection of renal allografts (2), and Crohn's disease (1). The average HF titer of the anti-p330d/CENP-F antibodies in the patients with cancer, 1:10,103, was significantly higher than the average titer in non-cancer patients, 1:3,200 (P=0.008). Autoimmunity to p330d/CENP-F appeared not to be associated with rheumatic diseases, in particular scleroderma, since only three of the 26 patients had rheumatic disease and the antibodies were not detected by IIF in a group of 351 patients with scleroderma and related disorders. Our findings, although retrospective and limited to a relatively small number of patients, point to the hypothesis that autoimmunity to p330d/CENP-F could be related to events involving increased or abnormal cell proliferation." @default.
- W2020418092 created "2016-06-24" @default.
- W2020418092 creator A5001248256 @default.
- W2020418092 creator A5014490649 @default.
- W2020418092 creator A5015631803 @default.
- W2020418092 creator A5035280308 @default.
- W2020418092 creator A5065446697 @default.
- W2020418092 date "1995-08-01" @default.
- W2020418092 modified "2023-09-27" @default.
- W2020418092 title "Autoimmunity to the cell cycle-dependent centromere protein p330d/CENP-F in disorders associated with cell proliferation" @default.
- W2020418092 cites W1522034188 @default.
- W2020418092 cites W1552738427 @default.
- W2020418092 cites W1919026068 @default.
- W2020418092 cites W1973151522 @default.
- W2020418092 cites W1998147517 @default.
- W2020418092 cites W1999158929 @default.
- W2020418092 cites W2003324907 @default.
- W2020418092 cites W2013360299 @default.
- W2020418092 cites W2020772885 @default.
- W2020418092 cites W2045654454 @default.
- W2020418092 cites W2047332694 @default.
- W2020418092 cites W2048346523 @default.
- W2020418092 cites W2052770746 @default.
- W2020418092 cites W2062414686 @default.
- W2020418092 cites W2066534425 @default.
- W2020418092 cites W2068032875 @default.
- W2020418092 cites W2075846600 @default.
- W2020418092 cites W2134668237 @default.
- W2020418092 cites W2268503109 @default.
- W2020418092 doi "https://doi.org/10.1016/0896-8411(95)90009-8" @default.
- W2020418092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7492351" @default.
- W2020418092 hasPublicationYear "1995" @default.
- W2020418092 type Work @default.
- W2020418092 sameAs 2020418092 @default.
- W2020418092 citedByCount "60" @default.
- W2020418092 countsByYear W20204180922013 @default.
- W2020418092 countsByYear W20204180922014 @default.
- W2020418092 countsByYear W20204180922015 @default.
- W2020418092 countsByYear W20204180922016 @default.
- W2020418092 countsByYear W20204180922017 @default.
- W2020418092 countsByYear W20204180922018 @default.
- W2020418092 countsByYear W20204180922019 @default.
- W2020418092 countsByYear W20204180922020 @default.
- W2020418092 crossrefType "journal-article" @default.
- W2020418092 hasAuthorship W2020418092A5001248256 @default.
- W2020418092 hasAuthorship W2020418092A5014490649 @default.
- W2020418092 hasAuthorship W2020418092A5015631803 @default.
- W2020418092 hasAuthorship W2020418092A5035280308 @default.
- W2020418092 hasAuthorship W2020418092A5065446697 @default.
- W2020418092 hasConcept C101180180 @default.
- W2020418092 hasConcept C159654299 @default.
- W2020418092 hasConcept C163764329 @default.
- W2020418092 hasConcept C180032290 @default.
- W2020418092 hasConcept C203014093 @default.
- W2020418092 hasConcept C2778236600 @default.
- W2020418092 hasConcept C2779075594 @default.
- W2020418092 hasConcept C2779967694 @default.
- W2020418092 hasConcept C2780130043 @default.
- W2020418092 hasConcept C32611913 @default.
- W2020418092 hasConcept C71924100 @default.
- W2020418092 hasConcept C86803240 @default.
- W2020418092 hasConceptScore W2020418092C101180180 @default.
- W2020418092 hasConceptScore W2020418092C159654299 @default.
- W2020418092 hasConceptScore W2020418092C163764329 @default.
- W2020418092 hasConceptScore W2020418092C180032290 @default.
- W2020418092 hasConceptScore W2020418092C203014093 @default.
- W2020418092 hasConceptScore W2020418092C2778236600 @default.
- W2020418092 hasConceptScore W2020418092C2779075594 @default.
- W2020418092 hasConceptScore W2020418092C2779967694 @default.
- W2020418092 hasConceptScore W2020418092C2780130043 @default.
- W2020418092 hasConceptScore W2020418092C32611913 @default.
- W2020418092 hasConceptScore W2020418092C71924100 @default.
- W2020418092 hasConceptScore W2020418092C86803240 @default.
- W2020418092 hasIssue "4" @default.
- W2020418092 hasLocation W20204180921 @default.
- W2020418092 hasLocation W20204180922 @default.
- W2020418092 hasOpenAccess W2020418092 @default.
- W2020418092 hasPrimaryLocation W20204180921 @default.
- W2020418092 hasRelatedWork W193921588 @default.
- W2020418092 hasRelatedWork W1996464156 @default.
- W2020418092 hasRelatedWork W2043428857 @default.
- W2020418092 hasRelatedWork W2058737939 @default.
- W2020418092 hasRelatedWork W2184265427 @default.
- W2020418092 hasRelatedWork W2325028715 @default.
- W2020418092 hasRelatedWork W2406420051 @default.
- W2020418092 hasRelatedWork W2425255793 @default.
- W2020418092 hasRelatedWork W2469794603 @default.
- W2020418092 hasRelatedWork W4376112749 @default.
- W2020418092 hasVolume "8" @default.
- W2020418092 isParatext "false" @default.
- W2020418092 isRetracted "false" @default.
- W2020418092 magId "2020418092" @default.
- W2020418092 workType "article" @default.