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• W2020434511 abstract "Fumagillin, an irreversible inhibitor of MetAP2, has been shown to potently inhibit growth of malaria parasites in vitro. Here, we demonstrate activity of fumagillin analogs with an improved pharmacokinetic profile against malaria parasites, trypanosomes, and amoebas. A subset of the compounds showed efficacy in a murine malaria model. The observed SAR forms a basis for further optimization of fumagillin based inhibitors against parasitic targets by inhibition of MetAP2." @default.
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• W2020434511 date "2009-09-01" @default.
• W2020434511 modified "2023-09-26" @default.
• W2020434511 title "Antiparasitic activities of novel, orally available fumagillin analogs" @default.
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• W2020434511 doi "https://doi.org/10.1016/j.bmcl.2009.07.029" @default.
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