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- W2020441410 abstract "Twenty amino acids form the basis of all proteins, but another two genetically encoded amino acids have also been discovered. The biosynthesis of one of these, pyrrolysine, has now been elucidated. See Letter p.647 Pyrrolysine, the latest addition to the ranks of the genetically encoded amino acids, is found in methanogenic archaea and bacteria, in which it is a necessary component of the enzymes involved in the formation of methane from methylamines. Its biosynthetic pathway remains poorly characterized. Joseph Krzycki and colleagues now show that lysine is the sole precursor for the pyrrolysine synthesis system of Methanosarcina sp. Archaea. The radical S-adenosyl-L-methionine protein PylB converts lysine to 3-methylornithine, which then undergoes a PylC-catalysed condensation with a second lysine to generate a product that is oxidized by PylD to generate pyrrolysine. The authors suggest that synthetic analogues of intermediates in this pathway may provide useful pyrrolysine derivatives that could be incorporated into tailored recombinant proteins." @default.
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- W2020441410 date "2011-03-01" @default.
- W2020441410 modified "2023-09-23" @default.
- W2020441410 title "How two amino acids become one" @default.
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- W2020441410 doi "https://doi.org/10.1038/471583a" @default.
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