FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020441471> ?p ?o ?g. }

• W2020441471 endingPage "e27435" @default.
• W2020441471 startingPage "e27435" @default.
• W2020441471 abstract "Listeria monocytogenes is a Gram-positive facultative intracellular pathogen, causing serious illness in immunocompromised individuals and pregnant women. Upon detection by macrophages, which are key players of the innate immune response against infection, L. monocytogenes induces specific host cell responses which need to be tightly controlled at transcriptional and post-transcriptional levels. Here, we ask whether and how host miRNAs, which represent an important mechanism of post-transcriptional regulation in a wide array of biological processes, are altered by a model pathogen upon live infection of murine bone marrow derived macrophages. We first report that L. monocytogenes subverts the host genome-wide miRNA profile of macrophages in vitro. Specifically, we show that miR-155, miR-146a, miR-125a-3p/5p and miR-149 were amongst the most significantly regulated miRNAs in infected macrophages. Strikingly, these miRNAs were highly upregulated upon infection with the Listeriolysin-deficient L. monocytogenes mutant Δhly, that cannot escape from the phagosome thus representing a vacuolar-contained infection. The vacuolar miRNA response was significantly reduced in macrophages deficient for MyD88. In addition, miR-146a and miR-125a-3p/5p were regulated at transcriptional levels upon infection, and miR-125a-3p/5p were found to be TLR2 responsive. Furthermore, miR-155 transactivation in infection was regulated by NF-κB p65, while miR-146a and miR-125a-3p/5p expression was unaffected in p65-deficient primary macrophages upon L. monocytogenes infection. Our results demonstrate that L. monocytogenes promotes significant changes in the miRNA expression profile in macrophages, and reveal a vacuolar-dependent miRNA signature, listeriolysin-independent and MyD88-dependent. These miRNAs are predicted to target immune genes and are therefore most likely involved in regulation of the macrophage innate immune response against infection at post-transcriptional levels." @default.
• W2020441471 created "2016-06-24" @default.
• W2020441471 creator A5026926166 @default.
• W2020441471 creator A5038075330 @default.
• W2020441471 creator A5049617844 @default.
• W2020441471 creator A5078354838 @default.
• W2020441471 creator A5079200229 @default.
• W2020441471 creator A5082057771 @default.
• W2020441471 creator A5086472692 @default.
• W2020441471 creator A5086853579 @default.
• W2020441471 date "2011-11-17" @default.
• W2020441471 modified "2023-09-25" @default.
• W2020441471 title "Listeria monocytogenes Infection in Macrophages Induces Vacuolar-Dependent Host miRNA Response" @default.
• W2020441471 cites W144423133 @default.
• W2020441471 cites W1535518980 @default.
• W2020441471 cites W1833918098 @default.
• W2020441471 cites W1964141567 @default.
• W2020441471 cites W1977745306 @default.
• W2020441471 cites W1978337436 @default.
• W2020441471 cites W1980269624 @default.
• W2020441471 cites W1996441871 @default.
• W2020441471 cites W2007993909 @default.
• W2020441471 cites W2017481656 @default.
• W2020441471 cites W2020932061 @default.
• W2020441471 cites W2022615823 @default.
• W2020441471 cites W2024475404 @default.
• W2020441471 cites W2025381177 @default.
• W2020441471 cites W2037890160 @default.
• W2020441471 cites W2049772720 @default.
• W2020441471 cites W2050444114 @default.
• W2020441471 cites W2054109341 @default.
• W2020441471 cites W2067647130 @default.
• W2020441471 cites W2070597700 @default.
• W2020441471 cites W2072076620 @default.
• W2020441471 cites W2075223145 @default.
• W2020441471 cites W2075860675 @default.
• W2020441471 cites W2081554080 @default.
• W2020441471 cites W2082213106 @default.
• W2020441471 cites W2085441977 @default.
• W2020441471 cites W2090219560 @default.
• W2020441471 cites W2092547796 @default.
• W2020441471 cites W2093012198 @default.
• W2020441471 cites W2094057765 @default.
• W2020441471 cites W2095125813 @default.
• W2020441471 cites W2101619948 @default.
• W2020441471 cites W2107277218 @default.
• W2020441471 cites W2109491705 @default.
• W2020441471 cites W2114047398 @default.
• W2020441471 cites W2117991391 @default.
• W2020441471 cites W2125945390 @default.
• W2020441471 cites W2130862272 @default.
• W2020441471 cites W2130946949 @default.
• W2020441471 cites W2132762707 @default.
• W2020441471 cites W2133613657 @default.
• W2020441471 cites W2144014651 @default.
• W2020441471 cites W2152561297 @default.
• W2020441471 cites W2161706967 @default.
• W2020441471 cites W2170252293 @default.
• W2020441471 cites W2171139781 @default.
• W2020441471 cites W2030362521 @default.
• W2020441471 cites W2047362768 @default.
• W2020441471 doi "https://doi.org/10.1371/journal.pone.0027435" @default.
• W2020441471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3219661" @default.
• W2020441471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22114673" @default.
• W2020441471 hasPublicationYear "2011" @default.
• W2020441471 type Work @default.
• W2020441471 sameAs 2020441471 @default.
• W2020441471 citedByCount "71" @default.
• W2020441471 countsByYear W20204414712012 @default.
• W2020441471 countsByYear W20204414712013 @default.
• W2020441471 countsByYear W20204414712014 @default.
• W2020441471 countsByYear W20204414712015 @default.
• W2020441471 countsByYear W20204414712016 @default.
• W2020441471 countsByYear W20204414712017 @default.
• W2020441471 countsByYear W20204414712018 @default.
• W2020441471 countsByYear W20204414712019 @default.
• W2020441471 countsByYear W20204414712020 @default.
• W2020441471 countsByYear W20204414712021 @default.
• W2020441471 countsByYear W20204414712022 @default.
• W2020441471 countsByYear W20204414712023 @default.
• W2020441471 crossrefType "journal-article" @default.
• W2020441471 hasAuthorship W2020441471A5026926166 @default.
• W2020441471 hasAuthorship W2020441471A5038075330 @default.
• W2020441471 hasAuthorship W2020441471A5049617844 @default.
• W2020441471 hasAuthorship W2020441471A5078354838 @default.
• W2020441471 hasAuthorship W2020441471A5079200229 @default.
• W2020441471 hasAuthorship W2020441471A5082057771 @default.
• W2020441471 hasAuthorship W2020441471A5086472692 @default.
• W2020441471 hasAuthorship W2020441471A5086853579 @default.
• W2020441471 hasBestOaLocation W20204414711 @default.
• W2020441471 hasConcept C104317684 @default.
• W2020441471 hasConcept C136449434 @default.
• W2020441471 hasConcept C145059251 @default.
• W2020441471 hasConcept C153726182 @default.
• W2020441471 hasConcept C160448771 @default.
• W2020441471 hasConcept C161478664 @default.
• W2020441471 hasConcept C202751555 @default.
• W2020441471 hasConcept C203014093 @default.

• next