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• W2020442012 abstract "Subtype C is the most prevalent clade in the HIV-1 pandemic. Previous studies suggested that African HIV-1 subtype C lacks a well-defined phylogenetic structure. Here we show that, by sequential pruning of ambiguously positioned taxa, a well-defined intrasubtype C phylogenetic structure becomes apparent, with 52% African HIV-1 subtype C isolates analyzed in envelope sequences branching within 11 clusters, also supported in a tree of full-length genomes, and all with geographical associations. Among 46 viruses recently transmitted in South Africa, 70% branched within 7 clusters (41% in the largest one) and 15% additional isolates were intercluster recombinants. Choice of the outgroup sequence and inclusion of intrasubtype recombinant viruses in the analyses could greatly affect support of clusters. The identification of clusters comprising a large proportion of African HIV-1 subtype C viruses may have implications for the design of vaccines intended for use in areas where subtype C is prevalent." @default.
• W2020442012 created "2016-06-24" @default.
• W2020442012 creator A5001203246 @default.
• W2020442012 creator A5010964400 @default.
• W2020442012 date "2011-06-01" @default.
• W2020442012 modified "2023-09-29" @default.
• W2020442012 title "Phylogenetic structure in African HIV-1 subtype C revealed by selective sequential pruning" @default.
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• W2020442012 doi "https://doi.org/10.1016/j.virol.2011.03.021" @default.
• W2020442012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21507449" @default.
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