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- W2020452562 abstract "Enamel, one of the tissues of the tooth, is the hardest and most highly mineralized substance of the human body. The interwoven architecture of enamel rods contributes to its strength and resistance to fracture. However, these rods still cannot prevent damage to the enamel caused by injury, dental caries, or developmental defects. It is a wellknown fact that enamel is formed by terminally differentiated ameloblasts that are induced by dental mesenchyme signals. Once the formation of enamel is complete and the tooth erupts, the ameloblasts commit apoptosis; furthermore, the enamel compartment is acellular in nature and has no blood/nerve supply to support self-regeneration. Defects in enamel may expose the underlying dentin with dentinal tubules, leading to sensitivity or pain, as well as allowing bacterial penetration, tooth pulp infection, and inflammation. In order to prevent the problem from advancing as well as to protect the tooth and improve cosmetic appearance, acid-etching techniques and application of artificial materials such as resin, amalgam, and other similar use materials are used by dentists. Resin restoration is the most popular method and acid-etching" @default.
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- W2020452562 date "2014-08-01" @default.
- W2020452562 modified "2023-10-13" @default.
- W2020452562 title "Cell culture-based computer-aided design/computer-aided manufacture bio-enamel as novel treatment for enamel defect" @default.
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- W2020452562 doi "https://doi.org/10.1016/j.jfma.2013.02.007" @default.
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