FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020453492> ?p ?o ?g. }

• W2020453492 endingPage "778" @default.
• W2020453492 startingPage "772" @default.
• W2020453492 abstract "1. Depolarization of mesangial cells has been shown to occur following an outward movement of chloride ions from the cell. We have shown previously that mesangial cells from the H-2Kb-tsA58 transgenic mouse possess a significant whole-cell chloride conductance and consequently are a suitable preparation for the study of potential chloride channel inhibitors. 2. The effects on the whole-cell chloride conductance of the chloride channel inhibitor, 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB) and the potassium channel openers, (KCOs) P1075 and pinacidil were investigated in mesangial cells from the H-2Kb-tsA58 transgenic mouse cultured in permissive conditions (at 33 degrees C in the presence of 50 u ml-1 murine gamma-interferon). 3. In symmetrical solutions of 140 mM tetramethylammonium chloride (TMAC1) the whole-cell chloride conductance was 1.08 +/- 0.05 nS (n = 63) and this could be reversibly inhibited by 5 x 10(-5) M NPPB. 4. Both P1075 and pinacidil inhibited the whole-cell chloride conductance. This inhibition was not reversible after drug washout and was demonstrated only when drugs were applied to the extracellular surface of the cells. Very low concentrations of the drugs were found to reduce the chloride conductance after 16 h incubation but under no circumstances studied was the conductance totally inhibited, leaving a mean residual current of 0.33 +/- 0.03 nS (n = 12). 5. The effects of different peptide calcium concentrations on the magnitude of the residual current in the presence of the drugs were investigated. The residual current was reduced with 10(-8) M calcium in the pipette and increased with 10(-3) M pipette calcium. Therefore, these data suggest that P1075 and pinacidil selectively inhibit a calcium-independent chloride conductance in mesangial cells from the H-2Kb-tsA58 transgenic mouse." @default.
• W2020453492 created "2016-06-24" @default.
• W2020453492 creator A5009611235 @default.
• W2020453492 creator A5042380725 @default.
• W2020453492 date "1996-10-01" @default.
• W2020453492 modified "2023-09-24" @default.
• W2020453492 title "Inhibition by P1075 and pinacidil of a calcium-independent chloride conductance in conditionally-immortal renal glomerular mesangial cells" @default.
• W2020453492 cites W1496902535 @default.
• W2020453492 cites W1966339894 @default.
• W2020453492 cites W1979132448 @default.
• W2020453492 cites W1992309013 @default.
• W2020453492 cites W1992671417 @default.
• W2020453492 cites W1997511216 @default.
• W2020453492 cites W1999506495 @default.
• W2020453492 cites W2001534689 @default.
• W2020453492 cites W2003520712 @default.
• W2020453492 cites W2005110831 @default.
• W2020453492 cites W2009480110 @default.
• W2020453492 cites W2009667219 @default.
• W2020453492 cites W2015426350 @default.
• W2020453492 cites W2016247671 @default.
• W2020453492 cites W2018983834 @default.
• W2020453492 cites W2033071419 @default.
• W2020453492 cites W2048512445 @default.
• W2020453492 cites W2056849948 @default.
• W2020453492 cites W2064827515 @default.
• W2020453492 cites W2093013713 @default.
• W2020453492 cites W2098302088 @default.
• W2020453492 cites W2106799985 @default.
• W2020453492 cites W2303555161 @default.
• W2020453492 cites W2313091483 @default.
• W2020453492 cites W2402642083 @default.
• W2020453492 cites W2408943659 @default.
• W2020453492 cites W2413949809 @default.
• W2020453492 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15739.x" @default.
• W2020453492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1915769" @default.
• W2020453492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8904654" @default.
• W2020453492 hasPublicationYear "1996" @default.
• W2020453492 type Work @default.
• W2020453492 sameAs 2020453492 @default.
• W2020453492 citedByCount "6" @default.
• W2020453492 countsByYear W20204534922018 @default.
• W2020453492 countsByYear W20204534922019 @default.
• W2020453492 crossrefType "journal-article" @default.
• W2020453492 hasAuthorship W2020453492A5009611235 @default.
• W2020453492 hasAuthorship W2020453492A5042380725 @default.
• W2020453492 hasBestOaLocation W20204534922 @default.
• W2020453492 hasConcept C114614502 @default.
• W2020453492 hasConcept C121932024 @default.
• W2020453492 hasConcept C12554922 @default.
• W2020453492 hasConcept C134018914 @default.
• W2020453492 hasConcept C145822097 @default.
• W2020453492 hasConcept C147944092 @default.
• W2020453492 hasConcept C170493617 @default.
• W2020453492 hasConcept C178790620 @default.
• W2020453492 hasConcept C185592680 @default.
• W2020453492 hasConcept C202751555 @default.
• W2020453492 hasConcept C2778695967 @default.
• W2020453492 hasConcept C2779131090 @default.
• W2020453492 hasConcept C33923547 @default.
• W2020453492 hasConcept C519063684 @default.
• W2020453492 hasConcept C55493867 @default.
• W2020453492 hasConcept C79879829 @default.
• W2020453492 hasConcept C86803240 @default.
• W2020453492 hasConceptScore W2020453492C114614502 @default.
• W2020453492 hasConceptScore W2020453492C121932024 @default.
• W2020453492 hasConceptScore W2020453492C12554922 @default.
• W2020453492 hasConceptScore W2020453492C134018914 @default.
• W2020453492 hasConceptScore W2020453492C145822097 @default.
• W2020453492 hasConceptScore W2020453492C147944092 @default.
• W2020453492 hasConceptScore W2020453492C170493617 @default.
• W2020453492 hasConceptScore W2020453492C178790620 @default.
• W2020453492 hasConceptScore W2020453492C185592680 @default.
• W2020453492 hasConceptScore W2020453492C202751555 @default.
• W2020453492 hasConceptScore W2020453492C2778695967 @default.
• W2020453492 hasConceptScore W2020453492C2779131090 @default.
• W2020453492 hasConceptScore W2020453492C33923547 @default.
• W2020453492 hasConceptScore W2020453492C519063684 @default.
• W2020453492 hasConceptScore W2020453492C55493867 @default.
• W2020453492 hasConceptScore W2020453492C79879829 @default.
• W2020453492 hasConceptScore W2020453492C86803240 @default.
• W2020453492 hasIssue "4" @default.
• W2020453492 hasLocation W20204534921 @default.
• W2020453492 hasLocation W20204534922 @default.
• W2020453492 hasLocation W20204534923 @default.
• W2020453492 hasLocation W20204534924 @default.
• W2020453492 hasOpenAccess W2020453492 @default.
• W2020453492 hasPrimaryLocation W20204534921 @default.
• W2020453492 hasRelatedWork W1982780003 @default.
• W2020453492 hasRelatedWork W2020597507 @default.
• W2020453492 hasRelatedWork W2028649830 @default.
• W2020453492 hasRelatedWork W2031781097 @default.
• W2020453492 hasRelatedWork W2041273449 @default.
• W2020453492 hasRelatedWork W2059582126 @default.
• W2020453492 hasRelatedWork W2071462777 @default.
• W2020453492 hasRelatedWork W2082066498 @default.
• W2020453492 hasRelatedWork W2336389055 @default.
• W2020453492 hasRelatedWork W64283687 @default.

• next