FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020455526> ?p ?o ?g. }

• W2020455526 endingPage "1484" @default.
• W2020455526 startingPage "1479" @default.
• W2020455526 abstract "The therapeutic use of procedures for genetic stem cell modification is limited by potential adverse events related to uncontrolled mutagenesis. Prominent findings have been made in hematopoietic gene therapy, demonstrating the risk of clonal, potentially malignant outgrowth on the basis of mutations acquired during or after therapeutic genome modification. The incidence and the growth rate of insertional mutants have been linked to the stemness of the target cells and vector-related features such as the integration pattern, the architecture, and the exact content of transgene cassettes. Milieu factors supporting the survival and expansion of mutants may eventually allow oncogenic progression. Similar concerns apply for medicinal products based on pluripotent stem cells. Focusing on the genetic stress induced by insertional mutagenesis and culture adaptation, we propose four conclusions. (a) Mutations occurring in the production of stem cell-based medicines may be unavoidable and need to be classified according to their risk to trigger the formation of clones that are sufficiently long-lived and mitotically active to acquire secondary transforming mutations. (b) The development of rational prevention strategies depends upon the identification of the specific mutations forming such dominant clones (which can also be addressed as cancer stem cell precursors) and a better knowledge of the mechanisms underlying their creation, expansion, and homeostatic control. (c) Quantitative assay systems are required to assess the practical value of preventive actions. (d) Improved approaches for the genetic modification of stem cells can address all critical steps in the origin and growth control of mutants." @default.
• W2020455526 created "2016-06-24" @default.
• W2020455526 creator A5001888046 @default.
• W2020455526 creator A5031540176 @default.
• W2020455526 creator A5047937141 @default.
• W2020455526 creator A5075459915 @default.
• W2020455526 date "2011-09-27" @default.
• W2020455526 modified "2023-10-08" @default.
• W2020455526 title "Concise Review: Managing Genotoxicity in the Therapeutic Modification of Stem Cells" @default.
• W2020455526 cites W1966427351 @default.
• W2020455526 cites W1966530560 @default.
• W2020455526 cites W1966983163 @default.
• W2020455526 cites W1966991523 @default.
• W2020455526 cites W1971062917 @default.
• W2020455526 cites W1971496676 @default.
• W2020455526 cites W1980868041 @default.
• W2020455526 cites W1984197757 @default.
• W2020455526 cites W1984433385 @default.
• W2020455526 cites W1985473731 @default.
• W2020455526 cites W1985964771 @default.
• W2020455526 cites W1986202050 @default.
• W2020455526 cites W1987600685 @default.
• W2020455526 cites W1987985505 @default.
• W2020455526 cites W1988865085 @default.
• W2020455526 cites W1996659151 @default.
• W2020455526 cites W1998591382 @default.
• W2020455526 cites W1998691251 @default.
• W2020455526 cites W2000059304 @default.
• W2020455526 cites W2003563611 @default.
• W2020455526 cites W2007294672 @default.
• W2020455526 cites W2010916683 @default.
• W2020455526 cites W2032570745 @default.
• W2020455526 cites W2035151737 @default.
• W2020455526 cites W2039081870 @default.
• W2020455526 cites W2040568539 @default.
• W2020455526 cites W2045433402 @default.
• W2020455526 cites W2045995615 @default.
• W2020455526 cites W2046013132 @default.
• W2020455526 cites W2049688202 @default.
• W2020455526 cites W2057879405 @default.
• W2020455526 cites W2061361780 @default.
• W2020455526 cites W2061645642 @default.
• W2020455526 cites W2074725342 @default.
• W2020455526 cites W2081339067 @default.
• W2020455526 cites W2081620485 @default.
• W2020455526 cites W2086663462 @default.
• W2020455526 cites W2090806364 @default.
• W2020455526 cites W2096910509 @default.
• W2020455526 cites W2097606337 @default.
• W2020455526 cites W2098597036 @default.
• W2020455526 cites W2099914822 @default.
• W2020455526 cites W2102049105 @default.
• W2020455526 cites W2107046588 @default.
• W2020455526 cites W2113669689 @default.
• W2020455526 cites W2118765054 @default.
• W2020455526 cites W2118929529 @default.
• W2020455526 cites W2119324304 @default.
• W2020455526 cites W2121444412 @default.
• W2020455526 cites W2125987139 @default.
• W2020455526 cites W2131115331 @default.
• W2020455526 cites W2136274459 @default.
• W2020455526 cites W2137440275 @default.
• W2020455526 cites W2140619976 @default.
• W2020455526 cites W2141621225 @default.
• W2020455526 cites W2142789319 @default.
• W2020455526 cites W2149294465 @default.
• W2020455526 cites W2150834451 @default.
• W2020455526 cites W2151531492 @default.
• W2020455526 cites W2155862946 @default.
• W2020455526 cites W2156338907 @default.
• W2020455526 cites W2157996490 @default.
• W2020455526 cites W2158979552 @default.
• W2020455526 cites W2159298101 @default.
• W2020455526 cites W2163404991 @default.
• W2020455526 cites W2167874626 @default.
• W2020455526 cites W2210954273 @default.
• W2020455526 doi "https://doi.org/10.1002/stem.716" @default.
• W2020455526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21898683" @default.
• W2020455526 hasPublicationYear "2011" @default.
• W2020455526 type Work @default.
• W2020455526 sameAs 2020455526 @default.
• W2020455526 citedByCount "41" @default.
• W2020455526 countsByYear W20204555262012 @default.
• W2020455526 countsByYear W20204555262013 @default.
• W2020455526 countsByYear W20204555262014 @default.
• W2020455526 countsByYear W20204555262015 @default.
• W2020455526 countsByYear W20204555262016 @default.
• W2020455526 countsByYear W20204555262017 @default.
• W2020455526 countsByYear W20204555262018 @default.
• W2020455526 countsByYear W20204555262020 @default.
• W2020455526 countsByYear W20204555262021 @default.
• W2020455526 countsByYear W20204555262022 @default.
• W2020455526 countsByYear W20204555262023 @default.
• W2020455526 crossrefType "journal-article" @default.
• W2020455526 hasAuthorship W2020455526A5001888046 @default.
• W2020455526 hasAuthorship W2020455526A5031540176 @default.
• W2020455526 hasAuthorship W2020455526A5047937141 @default.
• W2020455526 hasAuthorship W2020455526A5075459915 @default.

• next