Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020457207> ?p ?o ?g. }
- W2020457207 endingPage "10007" @default.
- W2020457207 startingPage "10002" @default.
- W2020457207 abstract "RANTES (regulated on activation normal T cell expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replication in vitro . We tested the influence of four RANTES single nucleotide polymorphism (SNP) variants and their haplotypes on HIV-1 infection and AIDS progression in five AIDS cohorts. Three SNPs in the RANTES gene region on chromosome 17 ( 403A in the promoter, In1.1C in the first intron, and 3 ′ 222C in the 3′ untranslated region) are associated with increased frequency of HIV-1 infection. The common In1.1C SNP allele is nested within an intronic regulatory sequence element that exhibits differential allele binding to nuclear proteins and a down-regulation of gene transcription. The In1.1C allele or haplotypes that include In1.1C display a strong dominant association with rapid progression to AIDS among HIV-1-infected individuals in African-American, European-American, and combined cohorts. The principal RANTES SNP genetic influence on AIDS progression derives from the down-regulating RANTES In1.1C allele, although linkage disequilibrium with adjoining RANTES SNPs including a weaker up-regulating RANTES promoter allele (− 28G ), can modify the observed epidemiological patterns. The In1.1C -bearing genotypes account for 37% of the attributable risk for rapid progression among African Americans and may also be an important influence on AIDS progression in Africa. The diminished transcription of RANTES afforded by the In1.1C regulatory allele is consistent with increased HIV-1 spread in vivo , leading to accelerated progression to AIDS." @default.
- W2020457207 created "2016-06-24" @default.
- W2020457207 creator A5012494061 @default.
- W2020457207 creator A5015368097 @default.
- W2020457207 creator A5024733766 @default.
- W2020457207 creator A5025642389 @default.
- W2020457207 creator A5026453706 @default.
- W2020457207 creator A5029043155 @default.
- W2020457207 creator A5034768148 @default.
- W2020457207 creator A5040215906 @default.
- W2020457207 creator A5053865342 @default.
- W2020457207 creator A5063971899 @default.
- W2020457207 creator A5070343534 @default.
- W2020457207 creator A5085788179 @default.
- W2020457207 date "2002-07-11" @default.
- W2020457207 modified "2023-10-11" @default.
- W2020457207 title "Modulating influence on HIV/AIDS by interacting<i>RANTES</i>gene variants" @default.
- W2020457207 cites W1485705546 @default.
- W2020457207 cites W1527933794 @default.
- W2020457207 cites W1530591884 @default.
- W2020457207 cites W1887682009 @default.
- W2020457207 cites W1891735350 @default.
- W2020457207 cites W1963813930 @default.
- W2020457207 cites W1964679138 @default.
- W2020457207 cites W1967210887 @default.
- W2020457207 cites W1984811742 @default.
- W2020457207 cites W1987164220 @default.
- W2020457207 cites W1992131811 @default.
- W2020457207 cites W2007021820 @default.
- W2020457207 cites W2013327449 @default.
- W2020457207 cites W2021699930 @default.
- W2020457207 cites W2031660981 @default.
- W2020457207 cites W2045775068 @default.
- W2020457207 cites W2048831587 @default.
- W2020457207 cites W2067964854 @default.
- W2020457207 cites W2072304983 @default.
- W2020457207 cites W2080350299 @default.
- W2020457207 cites W2080872140 @default.
- W2020457207 cites W2092289188 @default.
- W2020457207 cites W2094562745 @default.
- W2020457207 cites W2100992480 @default.
- W2020457207 cites W2106915606 @default.
- W2020457207 cites W2110182256 @default.
- W2020457207 cites W2114693995 @default.
- W2020457207 cites W2117196922 @default.
- W2020457207 cites W2126597682 @default.
- W2020457207 cites W2128401632 @default.
- W2020457207 cites W2138562527 @default.
- W2020457207 cites W2141003640 @default.
- W2020457207 cites W2147169218 @default.
- W2020457207 cites W2149730509 @default.
- W2020457207 cites W2152453984 @default.
- W2020457207 cites W2164953896 @default.
- W2020457207 cites W2417984407 @default.
- W2020457207 cites W87414302 @default.
- W2020457207 cites W94782037 @default.
- W2020457207 doi "https://doi.org/10.1073/pnas.142313799" @default.
- W2020457207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/126614" @default.
- W2020457207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12114533" @default.
- W2020457207 hasPublicationYear "2002" @default.
- W2020457207 type Work @default.
- W2020457207 sameAs 2020457207 @default.
- W2020457207 citedByCount "181" @default.
- W2020457207 countsByYear W20204572072012 @default.
- W2020457207 countsByYear W20204572072013 @default.
- W2020457207 countsByYear W20204572072014 @default.
- W2020457207 countsByYear W20204572072015 @default.
- W2020457207 countsByYear W20204572072016 @default.
- W2020457207 countsByYear W20204572072017 @default.
- W2020457207 countsByYear W20204572072018 @default.
- W2020457207 countsByYear W20204572072019 @default.
- W2020457207 countsByYear W20204572072021 @default.
- W2020457207 countsByYear W20204572072022 @default.
- W2020457207 countsByYear W20204572072023 @default.
- W2020457207 crossrefType "journal-article" @default.
- W2020457207 hasAuthorship W2020457207A5012494061 @default.
- W2020457207 hasAuthorship W2020457207A5015368097 @default.
- W2020457207 hasAuthorship W2020457207A5024733766 @default.
- W2020457207 hasAuthorship W2020457207A5025642389 @default.
- W2020457207 hasAuthorship W2020457207A5026453706 @default.
- W2020457207 hasAuthorship W2020457207A5029043155 @default.
- W2020457207 hasAuthorship W2020457207A5034768148 @default.
- W2020457207 hasAuthorship W2020457207A5040215906 @default.
- W2020457207 hasAuthorship W2020457207A5053865342 @default.
- W2020457207 hasAuthorship W2020457207A5063971899 @default.
- W2020457207 hasAuthorship W2020457207A5070343534 @default.
- W2020457207 hasAuthorship W2020457207A5085788179 @default.
- W2020457207 hasBestOaLocation W20204572071 @default.
- W2020457207 hasConcept C101762097 @default.
- W2020457207 hasConcept C104317684 @default.
- W2020457207 hasConcept C135763542 @default.
- W2020457207 hasConcept C139275648 @default.
- W2020457207 hasConcept C150194340 @default.
- W2020457207 hasConcept C153209595 @default.
- W2020457207 hasConcept C180754005 @default.
- W2020457207 hasConcept C197754878 @default.
- W2020457207 hasConcept C35605836 @default.
- W2020457207 hasConcept C54355233 @default.