Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020461749> ?p ?o ?g. }
- W2020461749 endingPage "81" @default.
- W2020461749 startingPage "75" @default.
- W2020461749 abstract "Summary Lipoprotein(a) and total plasma homocysteine levels are now established as independent atherothrombogenic risk factors. A distinctive pathophysiological feature of lipoprotein(a) is its antifibrinolytic activity, an effect dependent on plasma concentration and high affinity for fibrin of its small size apo(a) component. A stimulating effect of homocysteine on purified lipoprotein(a) has been proposed. However, little is known about their specific interactions in human plasma. We demonstrate by immunochemical, ligand-binding and plasminogen activation studies, that homocysteine modifies the structure and function of lipoprotein(a) in human plasma; it reduces the apo(a)/apoB disulfide bond causing the appearance of free apo(a) with high affinity for fibrin that inhibits plasminogen binding and plasmin formation (r= −0.995, p=0.002). These effects were evident particularly in plasma samples containing lipoprotein(a) with low affinity for fibrin and more than 22 kringles apo(a) isoforms. In contrast, for plasmas containing high fibrin affinity lipoprotein(a) (less than 22 kringles apo[a] isoforms) no significant change neither in fibrin binding nor in plasmin formation was observed. Furthermore, isolated apo(a) recombinants (10 to 34 kringles) that have been shown to display size-independent high affinity for fibrin were not affected by homocysteine, thus confirming lipoprotein(a) as its main target. These results suggest that the pro-atherogenic role already conferred to lipoprotein(a) by small apo(a) isoforms may be extended to large apo(a) isoforms if released in plasma by homocysteine, as this mechanism reveals their high fibrin affinity. Lipoprotein(a) and homocysteine may therefore constitute, if acting in concert, a new risk factor for athero-thrombotic vascular disease." @default.
- W2020461749 created "2016-06-24" @default.
- W2020461749 creator A5025673394 @default.
- W2020461749 creator A5038185169 @default.
- W2020461749 creator A5055724946 @default.
- W2020461749 creator A5068713469 @default.
- W2020461749 date "2005-01-01" @default.
- W2020461749 modified "2023-10-16" @default.
- W2020461749 title "Mechanism for the homocysteine-enhanced antifibrinolytic potential of lipoprotein(a) in human plasma" @default.
- W2020461749 cites W1636745306 @default.
- W2020461749 cites W1977726586 @default.
- W2020461749 cites W1984692718 @default.
- W2020461749 cites W1986171030 @default.
- W2020461749 cites W1989929999 @default.
- W2020461749 cites W1991387414 @default.
- W2020461749 cites W1994591574 @default.
- W2020461749 cites W1999374104 @default.
- W2020461749 cites W2010933740 @default.
- W2020461749 cites W2013427892 @default.
- W2020461749 cites W2013796621 @default.
- W2020461749 cites W2017809305 @default.
- W2020461749 cites W2018371791 @default.
- W2020461749 cites W2036170644 @default.
- W2020461749 cites W2037867041 @default.
- W2020461749 cites W2055032002 @default.
- W2020461749 cites W2056035471 @default.
- W2020461749 cites W2058970608 @default.
- W2020461749 cites W2071059887 @default.
- W2020461749 cites W2076860175 @default.
- W2020461749 cites W2078703458 @default.
- W2020461749 cites W2083516336 @default.
- W2020461749 cites W2086125246 @default.
- W2020461749 cites W2087316197 @default.
- W2020461749 cites W2087642197 @default.
- W2020461749 cites W2092004637 @default.
- W2020461749 cites W2097580954 @default.
- W2020461749 cites W2105383039 @default.
- W2020461749 cites W2111378321 @default.
- W2020461749 cites W2121141343 @default.
- W2020461749 cites W2124669509 @default.
- W2020461749 cites W2130483103 @default.
- W2020461749 cites W2134979646 @default.
- W2020461749 cites W2143544660 @default.
- W2020461749 cites W2149388878 @default.
- W2020461749 cites W2153129318 @default.
- W2020461749 cites W2160182135 @default.
- W2020461749 cites W2170703297 @default.
- W2020461749 cites W2197915700 @default.
- W2020461749 cites W2348855983 @default.
- W2020461749 cites W2417365582 @default.
- W2020461749 cites W2418007902 @default.
- W2020461749 doi "https://doi.org/10.1160/th04-12-0808" @default.
- W2020461749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16113787" @default.
- W2020461749 hasPublicationYear "2005" @default.
- W2020461749 type Work @default.
- W2020461749 sameAs 2020461749 @default.
- W2020461749 citedByCount "10" @default.
- W2020461749 countsByYear W20204617492012 @default.
- W2020461749 countsByYear W20204617492014 @default.
- W2020461749 countsByYear W20204617492015 @default.
- W2020461749 countsByYear W20204617492022 @default.
- W2020461749 countsByYear W20204617492023 @default.
- W2020461749 crossrefType "journal-article" @default.
- W2020461749 hasAuthorship W2020461749A5025673394 @default.
- W2020461749 hasAuthorship W2020461749A5038185169 @default.
- W2020461749 hasAuthorship W2020461749A5055724946 @default.
- W2020461749 hasAuthorship W2020461749A5068713469 @default.
- W2020461749 hasConcept C104317684 @default.
- W2020461749 hasConcept C141071460 @default.
- W2020461749 hasConcept C181199279 @default.
- W2020461749 hasConcept C185592680 @default.
- W2020461749 hasConcept C203014093 @default.
- W2020461749 hasConcept C2776104379 @default.
- W2020461749 hasConcept C2777090595 @default.
- W2020461749 hasConcept C2778163477 @default.
- W2020461749 hasConcept C2779036427 @default.
- W2020461749 hasConcept C2779637338 @default.
- W2020461749 hasConcept C2780072125 @default.
- W2020461749 hasConcept C2781071845 @default.
- W2020461749 hasConcept C2781436528 @default.
- W2020461749 hasConcept C2991743468 @default.
- W2020461749 hasConcept C53345823 @default.
- W2020461749 hasConcept C54173615 @default.
- W2020461749 hasConcept C55493867 @default.
- W2020461749 hasConcept C62746215 @default.
- W2020461749 hasConcept C71924100 @default.
- W2020461749 hasConcept C86803240 @default.
- W2020461749 hasConceptScore W2020461749C104317684 @default.
- W2020461749 hasConceptScore W2020461749C141071460 @default.
- W2020461749 hasConceptScore W2020461749C181199279 @default.
- W2020461749 hasConceptScore W2020461749C185592680 @default.
- W2020461749 hasConceptScore W2020461749C203014093 @default.
- W2020461749 hasConceptScore W2020461749C2776104379 @default.
- W2020461749 hasConceptScore W2020461749C2777090595 @default.
- W2020461749 hasConceptScore W2020461749C2778163477 @default.
- W2020461749 hasConceptScore W2020461749C2779036427 @default.
- W2020461749 hasConceptScore W2020461749C2779637338 @default.
- W2020461749 hasConceptScore W2020461749C2780072125 @default.