FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020468051> ?p ?o ?g. }

• W2020468051 endingPage "332" @default.
• W2020468051 startingPage "326" @default.
• W2020468051 abstract "The effective treatment of the rachitic symptoms of pseudo-vitamin D-deficiency rickets, type I (PVDRI) by massive doses of vitamin D3 was examined. For this purpose, the affinities and the maximum binding capacities (Bmax) of the plasma vitamin D-binding protein (DBP) and of the intestinal 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) receptor for vitamin D3, 25-hydroxyvitamin D3 (25-OHD3) and 1,25-(OH)2D3, were investigated in normal piglets and in rachitic piglets that suffered from PVDRI. The piglets were 5 to 10 weeks old and of both sexes. The Bmax of plasma DBP for 25-OHD3 was 6.77 +/- 0.45 microM for PVDRI piglets and 7.30 +/- 0.41 microM for control piglets and showed no differences between the two groups. Equilibrium association constants (Ka) of DBP for 25-OHD3 were 4.3 x 10(8) M-1 for PVDRI piglets and 4.0 x 10(8) M-1 for controls and showed also no differences between the two groups. Similarly the Ka of DBP for 1,25-(OH)2D3 was also the same for rachitic and control piglets (1.45 x 10(7) and 1.54 x 10(7) M-1, respectively). Due to the lower circulating concentration of 1,25-(OH)2D3 in the plasma of rachitic piglets compared to that of controls its free metabolite index was significantly lower in rachitic (0.42 +/- 0.05 x 10(-5)) than in control piglets (3.63 +/- 0.30 x 10(-5)). The Kd and Bmax of the intestinal nuclear receptor for 1,25-(OH)2D3 of rachitic and control piglets were 0.31 +/- 0.05 and 0.33 +/- 0.05 nM and 674 +/- 103 and 719 +/- 123 fmol/mg protein, respectively, and were also not different between the two groups of piglets. It was concluded from these observations that the rachitic symptoms of PVDRI piglets resulted solely from the lower free 1,25-(OH)2D3 concentration in plasma compared to that of normal piglets. The relative affinities of the intestinal 1,25-(OH)2D3 receptor for vitamin D3 and 25-OHD3 were also measured. It was found that 50% displacement of 1,25-(OH)2D3 from the intestinal receptor of PVDRI and control piglets required a 220,000- and 245,000-fold excess of the free concentration of vitamin D3, respectively, and a 20- to 42- and 23- to 71-fold excess of the free concentration of 25-OHD3, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2020468051 created "2016-06-24" @default.
• W2020468051 creator A5048503123 @default.
• W2020468051 creator A5056478089 @default.
• W2020468051 creator A5074265347 @default.
• W2020468051 date "1990-11-01" @default.
• W2020468051 modified "2023-10-18" @default.
• W2020468051 title "Binding properties of plasma vitamin D-binding protein and intestinal 1,25-dihydroxyvitamin D3 receptor in piglets with pseudo-vitamin D-deficiency rickets, type I: Treatment effects with pharmacological doses of vitamin D3" @default.
• W2020468051 cites W1579204819 @default.
• W2020468051 cites W1603801897 @default.
• W2020468051 cites W1870011663 @default.
• W2020468051 cites W1938576985 @default.
• W2020468051 cites W1965551729 @default.
• W2020468051 cites W1969607394 @default.
• W2020468051 cites W1993750643 @default.
• W2020468051 cites W2005709260 @default.
• W2020468051 cites W2010541650 @default.
• W2020468051 cites W2019792296 @default.
• W2020468051 cites W2022119243 @default.
• W2020468051 cites W2031657543 @default.
• W2020468051 cites W2032848335 @default.
• W2020468051 cites W2035135666 @default.
• W2020468051 cites W2051140417 @default.
• W2020468051 cites W2059992888 @default.
• W2020468051 cites W2062017044 @default.
• W2020468051 cites W2062361583 @default.
• W2020468051 cites W2074631079 @default.
• W2020468051 cites W2078066159 @default.
• W2020468051 cites W2078404458 @default.
• W2020468051 cites W2090876348 @default.
• W2020468051 cites W2091628949 @default.
• W2020468051 cites W2096602324 @default.
• W2020468051 cites W2118932178 @default.
• W2020468051 cites W2125489531 @default.
• W2020468051 cites W2140627813 @default.
• W2020468051 cites W2444686001 @default.
• W2020468051 doi "https://doi.org/10.1016/0003-9861(90)90124-h" @default.
• W2020468051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2173481" @default.
• W2020468051 hasPublicationYear "1990" @default.
• W2020468051 type Work @default.
• W2020468051 sameAs 2020468051 @default.
• W2020468051 citedByCount "6" @default.
• W2020468051 countsByYear W20204680512021 @default.
• W2020468051 countsByYear W20204680512022 @default.
• W2020468051 countsByYear W20204680512023 @default.
• W2020468051 crossrefType "journal-article" @default.
• W2020468051 hasAuthorship W2020468051A5048503123 @default.
• W2020468051 hasAuthorship W2020468051A5056478089 @default.
• W2020468051 hasAuthorship W2020468051A5074265347 @default.
• W2020468051 hasConcept C124490489 @default.
• W2020468051 hasConcept C126322002 @default.
• W2020468051 hasConcept C134018914 @default.
• W2020468051 hasConcept C153639570 @default.
• W2020468051 hasConcept C185592680 @default.
• W2020468051 hasConcept C2776079296 @default.
• W2020468051 hasConcept C2776489590 @default.
• W2020468051 hasConcept C2776940978 @default.
• W2020468051 hasConcept C2776941976 @default.
• W2020468051 hasConcept C2777477808 @default.
• W2020468051 hasConcept C2779740938 @default.
• W2020468051 hasConcept C2780106736 @default.
• W2020468051 hasConcept C71924100 @default.
• W2020468051 hasConceptScore W2020468051C124490489 @default.
• W2020468051 hasConceptScore W2020468051C126322002 @default.
• W2020468051 hasConceptScore W2020468051C134018914 @default.
• W2020468051 hasConceptScore W2020468051C153639570 @default.
• W2020468051 hasConceptScore W2020468051C185592680 @default.
• W2020468051 hasConceptScore W2020468051C2776079296 @default.
• W2020468051 hasConceptScore W2020468051C2776489590 @default.
• W2020468051 hasConceptScore W2020468051C2776940978 @default.
• W2020468051 hasConceptScore W2020468051C2776941976 @default.
• W2020468051 hasConceptScore W2020468051C2777477808 @default.
• W2020468051 hasConceptScore W2020468051C2779740938 @default.
• W2020468051 hasConceptScore W2020468051C2780106736 @default.
• W2020468051 hasConceptScore W2020468051C71924100 @default.
• W2020468051 hasIssue "2" @default.
• W2020468051 hasLocation W20204680511 @default.
• W2020468051 hasLocation W20204680512 @default.
• W2020468051 hasOpenAccess W2020468051 @default.
• W2020468051 hasPrimaryLocation W20204680511 @default.
• W2020468051 hasRelatedWork W1979666838 @default.
• W2020468051 hasRelatedWork W2020468051 @default.
• W2020468051 hasRelatedWork W2047013612 @default.
• W2020468051 hasRelatedWork W2062079718 @default.
• W2020468051 hasRelatedWork W2090876348 @default.
• W2020468051 hasRelatedWork W2091001271 @default.
• W2020468051 hasRelatedWork W2296140483 @default.
• W2020468051 hasRelatedWork W23032388 @default.
• W2020468051 hasRelatedWork W2335931427 @default.
• W2020468051 hasRelatedWork W2953259260 @default.
• W2020468051 hasVolume "282" @default.
• W2020468051 isParatext "false" @default.
• W2020468051 isRetracted "false" @default.
• W2020468051 magId "2020468051" @default.
• W2020468051 workType "article" @default.