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• W2020476203 abstract "It is well known that growth hormone (GH)-induced IGF-1 signaling plays a dominant role in postnatal muscle growth. Our previous studies have identified a growth factor, progranulin (PGRN), that is co-induced with IGF-1 upon GH administration. This result prompted us to explore the function of PGRN and its association with IGF-1. In the present study, we demonstrated that, similar to IGF-1, PGRN can promote C2C12 myotube hypertrophy via the PI(3)K/Akt/mTOR pathway. Moreover, PGRN can rescue the muscle atrophy phenotypes in C2C12 myotube when IGF-1 signaling is blocked. This result shows that PGRN can substitute for IGF-1 signaling in the regulation of muscle growth. Our findings provide new insights into IGF-1-modulated complicated networks that regulate muscle growth." @default.
• W2020476203 created "2016-06-24" @default.
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• W2020476203 date "2012-08-10" @default.
• W2020476203 modified "2023-10-09" @default.
• W2020476203 title "Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts<i>via</i>the PI3K/Akt/mTOR pathway" @default.
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• W2020476203 doi "https://doi.org/10.1016/j.febslet.2012.07.077" @default.
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