Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020477713> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2020477713 endingPage "365" @default.
- W2020477713 startingPage "360" @default.
- W2020477713 abstract "Objective: To investigate if treatment with a low daily dose of acetylsalicylic acid (ASA) may increase fibrin gel porosity in patients with diabetes mellitus. Design: A pilot-study. Setting: Out-patient clinic, Department of Endocrinology and Diabetology, Karolinska Hospital, Stockholm. Patients: 10 patients with type 1 diabetes. Interventions: Treatment with 75 mg ASA (Trombyl, Pharmacia & Upjohn, Uppsala, Sweden) once daily for 5 weeks. Venous blood samples were drawn before and at the end of the treatment period for determination of metabolic control, plasma fibrinogen level, and plasma fibrin gel structure. Main outcome measures: The long-term metabolic status was determined by fructosamine and glycosylated hemoglobin (HbA1c) in blood. The properties of the plasma fibrin gel structure, i.e. the permeability coefficient (Ks) and the fibre mass-length ratio (μ) formed in recalcified plasma on addition of thrombin were investigated. Results: The mean values of HbA1c and fructosamine were not significantly changed during, as compared to before, treatment with ASA. Plasma fibrinogen increased slightly (p = 0.05), while fibrin gel porosity, as assessed by Ks and μ, increased significantly (p < 0.05) in eight of the patients during treatment with ASA. The increase was most pronounced in three patients who at the same time improved HbA1c more than 10%. In contrast, Ks and μ decreased in two patients who experienced complications during the treatment. Conclusion: The results of this pilot study indicate that ASA may have positive effects on the fibrin gel porosity in patients with type 1 diabetes. However, long-term metabolic control seems also important, while the positive effects on fibrin gel structure seem abolished when inflammatory processes are present. Further studies are strongly needed to investigate factors influencing plasma fibrinogen and fibrin gel structure." @default.
- W2020477713 created "2016-06-24" @default.
- W2020477713 creator A5004048170 @default.
- W2020477713 creator A5023742132 @default.
- W2020477713 creator A5026021008 @default.
- W2020477713 date "1998-11-01" @default.
- W2020477713 modified "2023-10-16" @default.
- W2020477713 title "Fibrin gel structure in diabetic patients before and during treatment with acetylsalicylic acid: a pilot study" @default.
- W2020477713 cites W146872388 @default.
- W2020477713 cites W1572379239 @default.
- W2020477713 cites W1833780057 @default.
- W2020477713 cites W1970249515 @default.
- W2020477713 cites W1971027572 @default.
- W2020477713 cites W1978734462 @default.
- W2020477713 cites W1979189967 @default.
- W2020477713 cites W1996886562 @default.
- W2020477713 cites W2012818276 @default.
- W2020477713 cites W2013898879 @default.
- W2020477713 cites W2041109111 @default.
- W2020477713 cites W2046966664 @default.
- W2020477713 cites W2058372581 @default.
- W2020477713 cites W2063045100 @default.
- W2020477713 cites W2066188815 @default.
- W2020477713 cites W2080994996 @default.
- W2020477713 cites W2088826683 @default.
- W2020477713 cites W2093382345 @default.
- W2020477713 cites W2100861855 @default.
- W2020477713 cites W2106837301 @default.
- W2020477713 cites W2120299428 @default.
- W2020477713 cites W2120949451 @default.
- W2020477713 cites W2125326676 @default.
- W2020477713 cites W2133029684 @default.
- W2020477713 cites W2144537409 @default.
- W2020477713 cites W2331216347 @default.
- W2020477713 cites W2331879659 @default.
- W2020477713 cites W2340992823 @default.
- W2020477713 cites W2406332453 @default.
- W2020477713 cites W2408538721 @default.
- W2020477713 cites W4236219737 @default.
- W2020477713 cites W4239471829 @default.
- W2020477713 cites W4240967870 @default.
- W2020477713 cites W4252437054 @default.
- W2020477713 doi "https://doi.org/10.1016/s0268-9499(98)80394-9" @default.
- W2020477713 hasPublicationYear "1998" @default.
- W2020477713 type Work @default.
- W2020477713 sameAs 2020477713 @default.
- W2020477713 citedByCount "8" @default.
- W2020477713 countsByYear W20204777132012 @default.
- W2020477713 countsByYear W20204777132016 @default.
- W2020477713 countsByYear W20204777132017 @default.
- W2020477713 countsByYear W20204777132020 @default.
- W2020477713 crossrefType "journal-article" @default.
- W2020477713 hasAuthorship W2020477713A5004048170 @default.
- W2020477713 hasAuthorship W2020477713A5023742132 @default.
- W2020477713 hasAuthorship W2020477713A5026021008 @default.
- W2020477713 hasConcept C126322002 @default.
- W2020477713 hasConcept C134018914 @default.
- W2020477713 hasConcept C141071460 @default.
- W2020477713 hasConcept C203014093 @default.
- W2020477713 hasConcept C2778917026 @default.
- W2020477713 hasConcept C2779036427 @default.
- W2020477713 hasConcept C2781357877 @default.
- W2020477713 hasConcept C54173615 @default.
- W2020477713 hasConcept C555293320 @default.
- W2020477713 hasConcept C70818257 @default.
- W2020477713 hasConcept C71924100 @default.
- W2020477713 hasConcept C90924648 @default.
- W2020477713 hasConceptScore W2020477713C126322002 @default.
- W2020477713 hasConceptScore W2020477713C134018914 @default.
- W2020477713 hasConceptScore W2020477713C141071460 @default.
- W2020477713 hasConceptScore W2020477713C203014093 @default.
- W2020477713 hasConceptScore W2020477713C2778917026 @default.
- W2020477713 hasConceptScore W2020477713C2779036427 @default.
- W2020477713 hasConceptScore W2020477713C2781357877 @default.
- W2020477713 hasConceptScore W2020477713C54173615 @default.
- W2020477713 hasConceptScore W2020477713C555293320 @default.
- W2020477713 hasConceptScore W2020477713C70818257 @default.
- W2020477713 hasConceptScore W2020477713C71924100 @default.
- W2020477713 hasConceptScore W2020477713C90924648 @default.
- W2020477713 hasIssue "6" @default.
- W2020477713 hasLocation W20204777131 @default.
- W2020477713 hasOpenAccess W2020477713 @default.
- W2020477713 hasPrimaryLocation W20204777131 @default.
- W2020477713 hasRelatedWork W1979911809 @default.
- W2020477713 hasRelatedWork W1989190820 @default.
- W2020477713 hasRelatedWork W1999173190 @default.
- W2020477713 hasRelatedWork W2024571772 @default.
- W2020477713 hasRelatedWork W2395339221 @default.
- W2020477713 hasRelatedWork W2395422862 @default.
- W2020477713 hasRelatedWork W2411388856 @default.
- W2020477713 hasRelatedWork W2413674498 @default.
- W2020477713 hasRelatedWork W2416016672 @default.
- W2020477713 hasRelatedWork W70725711 @default.
- W2020477713 hasVolume "12" @default.
- W2020477713 isParatext "false" @default.
- W2020477713 isRetracted "false" @default.
- W2020477713 magId "2020477713" @default.
- W2020477713 workType "article" @default.