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- W2020478033 abstract "Nanoscience is now an expanding field of research and finds potential application in biomedical area, but it is limited due to lack of comprehensive knowledge of the interactions operating in nano-bio system. Here, we report the studies on the interaction and formation of nano-bio complex between silver nanoparticle (AgNP) and human blood protein hemoglobin (Hb). We have employed several spectroscopic (absorption, emission, Raman, FTIR, CD, etc.) and electron diffraction techniques (FE-SEM and HR-TEM) to characterize the Hb-AgNP complex system. Our results show the Hb-AgNP interaction is concentration and time dependent. The AgNP particle can attach/come closer to heme, tryptophan, and amide as well aromatic amine residues. As a result, the Hb undergoes conformational change and becomes unfolded through the increment of β-sheet structure. The AgNP-Hb can form charge-transfers (CT) complex where the Hb-heme along with the AgNP involved in the electron transfer mechanism and form Hb-AgNP assembled structure. The electron transfer mechanism has been found to be dependent on the size of silver particle. The overall study is important in understanding the nano-bio system and in predicting the avenues to design and synthesis of novel nano-biocomposite materials in material science and biomedical area." @default.
- W2020478033 created "2016-06-24" @default.
- W2020478033 creator A5019930571 @default.
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- W2020478033 creator A5091490086 @default.
- W2020478033 date "2011-11-01" @default.
- W2020478033 modified "2023-10-18" @default.
- W2020478033 title "Study of silver nanoparticle–hemoglobin interaction and composite formation" @default.
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- W2020478033 doi "https://doi.org/10.1016/j.colsurfb.2011.06.024" @default.
- W2020478033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21788120" @default.
- W2020478033 hasPublicationYear "2011" @default.
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