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- W2020478637 endingPage "1252" @default.
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- W2020478637 abstract "The N-end rule finds a physiological function The N-end–rule pathway for protein degradation is a canonical degradation pathway discovered in the 1980s. In recent years, studies have focused on finding novel variant pathways of N-end recognition. The “classical” pathway is blocked by N-terminal acetylation of the substrate. However, in yeast, N-terminal acetylation need not block degradation, because a second pathway can act on acetylated N-termini. But is this alternate pathway a major player in the physiology of mammals? Park et al. now confirm the existence of the alternate pathway in mammalian cells. Most notably, patient-derived point mutations thought to confer hypertension in humans affect susceptibility to this pathway for the encoded protein substrate, Rgs2. Science , this issue p. 1249" @default.
- W2020478637 created "2016-06-24" @default.
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- W2020478637 date "2015-03-13" @default.
- W2020478637 modified "2023-10-16" @default.
- W2020478637 title "Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway" @default.
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