FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020480436> ?p ?o ?g. }

• W2020480436 endingPage "228" @default.
• W2020480436 startingPage "218" @default.
• W2020480436 abstract "Melanocortin peptides are endogenously produced peptides originating from the posttranslational processing of the pro-opiomelanocortin hormone (POMC), exerting their effect by binding to class A G-protein-coupled 7 transmembrane domain receptors, positively coupled to adenylate cyclase. To date five melanocortin receptors have been identified and termed MC1 to MC5. MC1 and MC3 have previously been proposed to exert anti-inflammatory effects by modulating the host inflammatory response. The expression and the functional activity of both receptors was identified and confirmed in the C-20/A4 chondrocyte cell-line, isolated primary bovine and in situ bovine articular chondrocytes. Pro-inflammatory cytokines including IL-1?, IL-6, IL-8, TNF-?, produced by activated articular chondrocytes significantly up-regulate matrix metalloproteinases (MMPs) gene expression, and inhibit the chondrocyte’s compensatory synthesis pathways required to restore the integrity of the degraded extracellular matrix (ECM). Human C-20/A4 and primary bovine articular chondrocytes were found to produce CC and CXC chemokines, which induced the release of matrix degrading enzymes and activated cell apoptotic pathways. TNF-? significantly up-regulated the expression of pro-inflammatory cytokines and chemokines IL-1?, IL-6, IL-8, MCP-1 and MMP1 and 13 from C-20/A4 cell line and freshly isolated primary bovine articular chondrocytes. An effect attenuated in the presence of ?-MSH and D[TRP]8-?-MSH. The MC3/4 antagonist SHU9119 blocked the effects of D[TRP]8-?-MSH but not ?-MSH. TNF-? (60.0 pg/ml) stimulation caused ~30% cell death and was partially, but significantly inhibited by treatment of the cells with the melanocortin peptides. The antiinflammatory and chondroprotective effect of melanocortin peptides were then tested on in situ bovine articular chondrocytes, injured by a single blunt impact delivered by a drop tower. The mechanical injury caused significant cell death and up-regulation of the proinflammatory cytokines IL-6 and IL-8, which were significantly reduced on pre-treatment of cartilage explants with melanocortin peptides. Modulation of pro-inflammatory pathways and inflammation-modulated cartilage destruction with subsequent chondrocyte apoptosis appears to be logical development in the potential medical therapy of OA. The small molecular weight of melanocortin peptides should facilitate the absorption from the GI tract and the movement to the cartilage matrix, which together with creative drug delivery methods might potentially prove to be potent therapeutic agents in the future." @default.
• W2020480436 created "2016-06-24" @default.
• W2020480436 creator A5060792545 @default.
• W2020480436 creator A5071810470 @default.
• W2020480436 creator A5083744621 @default.
• W2020480436 date "2014-02-08" @default.
• W2020480436 modified "2023-10-13" @default.
• W2020480436 title "Enhanced biodegradation of phenanthrene using different inoculum types in a microbial fuel cell" @default.
• W2020480436 cites W1972276806 @default.
• W2020480436 cites W1978925134 @default.
• W2020480436 cites W2008061176 @default.
• W2020480436 cites W2009319690 @default.
• W2020480436 cites W2010099920 @default.
• W2020480436 cites W2013092969 @default.
• W2020480436 cites W2021239239 @default.
• W2020480436 cites W2022147977 @default.
• W2020480436 cites W2023454851 @default.
• W2020480436 cites W2028328511 @default.
• W2020480436 cites W2033096181 @default.
• W2020480436 cites W2033771476 @default.
• W2020480436 cites W2037840325 @default.
• W2020480436 cites W2038276542 @default.
• W2020480436 cites W2038810098 @default.
• W2020480436 cites W2051682229 @default.
• W2020480436 cites W2053941292 @default.
• W2020480436 cites W2062862686 @default.
• W2020480436 cites W2070231061 @default.
• W2020480436 cites W2072151672 @default.
• W2020480436 cites W2093473097 @default.
• W2020480436 cites W2094576437 @default.
• W2020480436 cites W2096265135 @default.
• W2020480436 cites W2102883721 @default.
• W2020480436 cites W2105762669 @default.
• W2020480436 cites W2107743250 @default.
• W2020480436 cites W2114628897 @default.
• W2020480436 cites W2114769310 @default.
• W2020480436 cites W2117842590 @default.
• W2020480436 cites W2149836467 @default.
• W2020480436 cites W2150797990 @default.
• W2020480436 cites W2166479872 @default.
• W2020480436 cites W2168225963 @default.
• W2020480436 doi "https://doi.org/10.1002/elsc.201300089" @default.
• W2020480436 hasPublicationYear "2014" @default.
• W2020480436 type Work @default.
• W2020480436 sameAs 2020480436 @default.
• W2020480436 citedByCount "44" @default.
• W2020480436 countsByYear W20204804362015 @default.
• W2020480436 countsByYear W20204804362016 @default.
• W2020480436 countsByYear W20204804362017 @default.
• W2020480436 countsByYear W20204804362018 @default.
• W2020480436 countsByYear W20204804362019 @default.
• W2020480436 countsByYear W20204804362020 @default.
• W2020480436 countsByYear W20204804362021 @default.
• W2020480436 countsByYear W20204804362022 @default.
• W2020480436 countsByYear W20204804362023 @default.
• W2020480436 crossrefType "journal-article" @default.
• W2020480436 hasAuthorship W2020480436A5060792545 @default.
• W2020480436 hasAuthorship W2020480436A5071810470 @default.
• W2020480436 hasAuthorship W2020480436A5083744621 @default.
• W2020480436 hasConcept C107872376 @default.
• W2020480436 hasConcept C147789679 @default.
• W2020480436 hasConcept C157021035 @default.
• W2020480436 hasConcept C165337572 @default.
• W2020480436 hasConcept C17525397 @default.
• W2020480436 hasConcept C178790620 @default.
• W2020480436 hasConcept C185592680 @default.
• W2020480436 hasConcept C2776891815 @default.
• W2020480436 hasConcept C523546767 @default.
• W2020480436 hasConcept C54355233 @default.
• W2020480436 hasConcept C86803240 @default.
• W2020480436 hasConcept C89395315 @default.
• W2020480436 hasConcept C89423630 @default.
• W2020480436 hasConceptScore W2020480436C107872376 @default.
• W2020480436 hasConceptScore W2020480436C147789679 @default.
• W2020480436 hasConceptScore W2020480436C157021035 @default.
• W2020480436 hasConceptScore W2020480436C165337572 @default.
• W2020480436 hasConceptScore W2020480436C17525397 @default.
• W2020480436 hasConceptScore W2020480436C178790620 @default.
• W2020480436 hasConceptScore W2020480436C185592680 @default.
• W2020480436 hasConceptScore W2020480436C2776891815 @default.
• W2020480436 hasConceptScore W2020480436C523546767 @default.
• W2020480436 hasConceptScore W2020480436C54355233 @default.
• W2020480436 hasConceptScore W2020480436C86803240 @default.
• W2020480436 hasConceptScore W2020480436C89395315 @default.
• W2020480436 hasConceptScore W2020480436C89423630 @default.
• W2020480436 hasIssue "2" @default.
• W2020480436 hasLocation W20204804361 @default.
• W2020480436 hasOpenAccess W2020480436 @default.
• W2020480436 hasPrimaryLocation W20204804361 @default.
• W2020480436 hasRelatedWork W1991478576 @default.
• W2020480436 hasRelatedWork W2032447024 @default.
• W2020480436 hasRelatedWork W2082385714 @default.
• W2020480436 hasRelatedWork W2084808947 @default.
• W2020480436 hasRelatedWork W2086718376 @default.
• W2020480436 hasRelatedWork W2090531632 @default.
• W2020480436 hasRelatedWork W2347654004 @default.
• W2020480436 hasRelatedWork W2764079670 @default.
• W2020480436 hasRelatedWork W4243372031 @default.

• next