Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020481489> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2020481489 endingPage "71" @default.
- W2020481489 startingPage "63" @default.
- W2020481489 abstract "Disabling orthostatic hypotension, due to insufficiency of the autonomic nervous system, is a common complication of type I familial amyloidotic polyneuropathy (FAP). We investigated whether oral treatment with L-threo-3,4-dihydroxyphenylserine (L-threo-Dops), a noradrenaline precursor, might be of therapeutical benefit. In twenty untreated FAP patients, aged 33 to 44 years, who, because of severe orthostatic hypotension, were bedridden or constrained to a sitting life, supine and erect blood pressure (BP), plasma noradrenaline and tilting time, defined as the interval (s) between the beginning of a 60 degrees head-up tilt and the occurrence of orthostatic symptoms (dizziness, blurred vision or near syncope) were determined before and at repeated intervals during oral treatment with L-threo-Dops, 100 mg bid, for 6 months. Before treatment supine mean BP was 80 (76-85) mmHg (mean and 95% CI), supine plasma noradrenaline was low, 59 (41-77) pg/ml and tilting time ranged from 38 to 118 s. In response to tilt, mean BP immediately fell by 36 (31-41) mmHg, whereas plasma noradrenaline increased by only 11 (0-21) pg/ml (p = 0.05). After 3 to 5 days of treatment with L-threo-Dops all patients experienced marked improvement of their orthostatic tolerance as reflected by their ability to walk freely around. This effect sustained throughout the six months of treatment. Plasma noradrenaline increased moderately by 37 (11-63) pg/ml (p = 0.02) and supine mean BP increased by 8.6 (5.8-12.4) mmHg (p < 0.001) during chronic treatment. Supine or nocturnal hypertension did not develop, the fall in mean BP in response to tilt diminished by 12.5 (6.5-17.3) mmHg (p < 0.001) and tilting time became longer than 600 s in all patients. Because of its efficacy, its sustained duration of action and the lack of side effects, L-threo-Dops is advocated to improve orthostatic tolerance in patients with autonomic insufficiency due to FAP." @default.
- W2020481489 created "2016-06-24" @default.
- W2020481489 creator A5013030227 @default.
- W2020481489 creator A5018900035 @default.
- W2020481489 creator A5032867268 @default.
- W2020481489 creator A5033149984 @default.
- W2020481489 creator A5063227767 @default.
- W2020481489 creator A5081863442 @default.
- W2020481489 creator A5085817090 @default.
- W2020481489 date "1997-01-01" @default.
- W2020481489 modified "2023-10-03" @default.
- W2020481489 title "Improved orthostatic tolerance in familial amyloidotic polyneuropathy with unnatural noradrenaline precursor l-threo-3,4-dihydroxyphenylserine" @default.
- W2020481489 cites W1977195971 @default.
- W2020481489 cites W2016930634 @default.
- W2020481489 cites W2021201908 @default.
- W2020481489 cites W2022785972 @default.
- W2020481489 cites W2025557786 @default.
- W2020481489 cites W2036329071 @default.
- W2020481489 cites W2058565111 @default.
- W2020481489 cites W2068884332 @default.
- W2020481489 cites W2082511468 @default.
- W2020481489 cites W2082701484 @default.
- W2020481489 cites W2089966043 @default.
- W2020481489 cites W2098603906 @default.
- W2020481489 cites W2125016949 @default.
- W2020481489 cites W2141820229 @default.
- W2020481489 cites W2150425477 @default.
- W2020481489 cites W2165292424 @default.
- W2020481489 cites W2179416980 @default.
- W2020481489 cites W2198986897 @default.
- W2020481489 cites W2413777479 @default.
- W2020481489 cites W2571242457 @default.
- W2020481489 cites W2617589934 @default.
- W2020481489 doi "https://doi.org/10.1016/s0165-1838(96)00110-5" @default.
- W2020481489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9021651" @default.
- W2020481489 hasPublicationYear "1997" @default.
- W2020481489 type Work @default.
- W2020481489 sameAs 2020481489 @default.
- W2020481489 citedByCount "22" @default.
- W2020481489 countsByYear W20204814892013 @default.
- W2020481489 countsByYear W20204814892015 @default.
- W2020481489 countsByYear W20204814892017 @default.
- W2020481489 countsByYear W20204814892018 @default.
- W2020481489 crossrefType "journal-article" @default.
- W2020481489 hasAuthorship W2020481489A5013030227 @default.
- W2020481489 hasAuthorship W2020481489A5018900035 @default.
- W2020481489 hasAuthorship W2020481489A5032867268 @default.
- W2020481489 hasAuthorship W2020481489A5033149984 @default.
- W2020481489 hasAuthorship W2020481489A5063227767 @default.
- W2020481489 hasAuthorship W2020481489A5081863442 @default.
- W2020481489 hasAuthorship W2020481489A5085817090 @default.
- W2020481489 hasConcept C125567185 @default.
- W2020481489 hasConcept C126322002 @default.
- W2020481489 hasConcept C134018914 @default.
- W2020481489 hasConcept C2775892965 @default.
- W2020481489 hasConcept C2778514916 @default.
- W2020481489 hasConcept C2780081974 @default.
- W2020481489 hasConcept C2781177144 @default.
- W2020481489 hasConcept C42219234 @default.
- W2020481489 hasConcept C513476851 @default.
- W2020481489 hasConcept C71924100 @default.
- W2020481489 hasConcept C73787029 @default.
- W2020481489 hasConcept C81182388 @default.
- W2020481489 hasConcept C84393581 @default.
- W2020481489 hasConceptScore W2020481489C125567185 @default.
- W2020481489 hasConceptScore W2020481489C126322002 @default.
- W2020481489 hasConceptScore W2020481489C134018914 @default.
- W2020481489 hasConceptScore W2020481489C2775892965 @default.
- W2020481489 hasConceptScore W2020481489C2778514916 @default.
- W2020481489 hasConceptScore W2020481489C2780081974 @default.
- W2020481489 hasConceptScore W2020481489C2781177144 @default.
- W2020481489 hasConceptScore W2020481489C42219234 @default.
- W2020481489 hasConceptScore W2020481489C513476851 @default.
- W2020481489 hasConceptScore W2020481489C71924100 @default.
- W2020481489 hasConceptScore W2020481489C73787029 @default.
- W2020481489 hasConceptScore W2020481489C81182388 @default.
- W2020481489 hasConceptScore W2020481489C84393581 @default.
- W2020481489 hasIssue "1-2" @default.
- W2020481489 hasLocation W20204814891 @default.
- W2020481489 hasLocation W20204814892 @default.
- W2020481489 hasOpenAccess W2020481489 @default.
- W2020481489 hasPrimaryLocation W20204814891 @default.
- W2020481489 hasRelatedWork W1522661 @default.
- W2020481489 hasRelatedWork W1669850877 @default.
- W2020481489 hasRelatedWork W2005071390 @default.
- W2020481489 hasRelatedWork W2017997997 @default.
- W2020481489 hasRelatedWork W2020481489 @default.
- W2020481489 hasRelatedWork W2432724465 @default.
- W2020481489 hasRelatedWork W2493566683 @default.
- W2020481489 hasRelatedWork W2565114362 @default.
- W2020481489 hasRelatedWork W2797016388 @default.
- W2020481489 hasRelatedWork W3082033917 @default.
- W2020481489 hasVolume "62" @default.
- W2020481489 isParatext "false" @default.
- W2020481489 isRetracted "false" @default.
- W2020481489 magId "2020481489" @default.
- W2020481489 workType "article" @default.