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- W2020482885 abstract "The effect of the sulfhydryl reagent, thimerosal (TMS) on meiosis resumption in germinal vesicle (GV)-stage denuded mouse oocytes was studied. It irreversibly inhibits both GV breakdown (GVBD) and the first polar body (pb1) extrusion in concentration- and time-dependent manners, the most striking result being the very early and narrow temporal window during which denuded primary oocytes released from their follicle are susceptible to a pulse of the drug. This inhibition is bypassed by dithiothreitol (DTT) with an efficiency declining with time, while thiosalicylic acid (TA), an analog of TMS devoid of the mercury atom, has no effect on meiosis reinitiation. These results strongly suggest that the inhibitory effect of TMS is a consequence of its sulfhydryl group oxidising activity. The molecular target(s) of this inhibitory oxidation should however be identified. In contrast to DTT, okadaic acid (OA), known to bypass the inhibitory effect of drugs interfering with protein kinase activities, only induces chromatin condensation and GVBD in TMS-pulsed oocytes with a delay of about 8 hr as compared to the control situation. This confirms that a very early thiol oxidation induced by TMS exerts a much more dramatic effect on resumption on meiosis than any pharmacological manipulation of protein kinase activities leading to activation of MPF." @default.
- W2020482885 created "2016-06-24" @default.
- W2020482885 creator A5002935968 @default.
- W2020482885 creator A5029712506 @default.
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- W2020482885 date "2003-06-26" @default.
- W2020482885 modified "2023-09-27" @default.
- W2020482885 title "The thiol reagent, thimerosal, irreversibly inhibits meiosis reinitiation in mouse oocyte when applied during a very early and narrow temporal window: A pharmacological analysis" @default.
- W2020482885 cites W1434994921 @default.
- W2020482885 cites W1501322875 @default.
- W2020482885 cites W1518265004 @default.
- W2020482885 cites W1532237107 @default.
- W2020482885 cites W1567797793 @default.
- W2020482885 cites W1900946340 @default.
- W2020482885 cites W191075509 @default.
- W2020482885 cites W1927345484 @default.
- W2020482885 cites W1964881942 @default.
- W2020482885 cites W1966221092 @default.
- W2020482885 cites W1966371752 @default.
- W2020482885 cites W1968446974 @default.
- W2020482885 cites W1972301357 @default.
- W2020482885 cites W1977753278 @default.
- W2020482885 cites W1978827509 @default.
- W2020482885 cites W1980166477 @default.
- W2020482885 cites W1981617042 @default.
- W2020482885 cites W1982396803 @default.
- W2020482885 cites W1986140299 @default.
- W2020482885 cites W1986619069 @default.
- W2020482885 cites W1995376834 @default.
- W2020482885 cites W1995618372 @default.
- W2020482885 cites W1996659179 @default.
- W2020482885 cites W1998104191 @default.
- W2020482885 cites W2000378381 @default.
- W2020482885 cites W2001644793 @default.
- W2020482885 cites W2003123442 @default.
- W2020482885 cites W2003518121 @default.
- W2020482885 cites W2003914219 @default.
- W2020482885 cites W2009455793 @default.
- W2020482885 cites W2009832420 @default.
- W2020482885 cites W2010134182 @default.
- W2020482885 cites W2010348828 @default.
- W2020482885 cites W2013864534 @default.
- W2020482885 cites W2015179609 @default.
- W2020482885 cites W2015335079 @default.
- W2020482885 cites W2015376124 @default.
- W2020482885 cites W2015816601 @default.
- W2020482885 cites W2023640845 @default.
- W2020482885 cites W2024679680 @default.
- W2020482885 cites W2038087932 @default.
- W2020482885 cites W2040182585 @default.
- W2020482885 cites W2040742434 @default.
- W2020482885 cites W2042001439 @default.
- W2020482885 cites W2044697175 @default.
- W2020482885 cites W2049121094 @default.
- W2020482885 cites W2054167608 @default.
- W2020482885 cites W2054785209 @default.
- W2020482885 cites W2057575068 @default.
- W2020482885 cites W2057856508 @default.
- W2020482885 cites W2059552522 @default.
- W2020482885 cites W2061425302 @default.
- W2020482885 cites W2062143530 @default.
- W2020482885 cites W2062846025 @default.
- W2020482885 cites W2072437360 @default.
- W2020482885 cites W2072882191 @default.
- W2020482885 cites W2076036495 @default.
- W2020482885 cites W2085265684 @default.
- W2020482885 cites W2085922126 @default.
- W2020482885 cites W2086065239 @default.
- W2020482885 cites W2086197263 @default.
- W2020482885 cites W2089021149 @default.
- W2020482885 cites W2093188668 @default.
- W2020482885 cites W2095024931 @default.
- W2020482885 cites W2100145851 @default.
- W2020482885 cites W2107279266 @default.
- W2020482885 cites W2109204235 @default.
- W2020482885 cites W2128437149 @default.
- W2020482885 cites W2143040768 @default.
- W2020482885 cites W2143274441 @default.
- W2020482885 cites W2145678727 @default.
- W2020482885 cites W2150083639 @default.
- W2020482885 cites W2152425930 @default.
- W2020482885 cites W2183548956 @default.
- W2020482885 cites W2240467006 @default.
- W2020482885 cites W50942224 @default.
- W2020482885 cites W56233763 @default.
- W2020482885 doi "https://doi.org/10.1002/mrd.10319" @default.
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