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• W2020486987 startingPage "870" @default.
• W2020486987 abstract "Abstract Kiss1, a neuropeptide predominantly expressed in the habenula, modulates the serotonin (5‐HT) system to decrease odorant cue [alarm substance (AS)]‐evoked fear behaviour in the zebrafish. The purpose of this study was to assess the interaction of Kiss1 with the 5‐HT system as well as to determine the involvement of the 5‐HT receptor subtypes in AS‐evoked fear. We utilized 0. 28 mg/kg WAY 100635 (WAY), a selective 5‐HT 1A receptor antagonist, to observe the effects of Kiss1 administration on AS‐evoked fear. We found WAY significantly inhibited the anxiolytic effects of Kiss1 ( p < 0.001) with an exception of freezing behaviour. Based on this, we utilized 92.79 mg/kg methysergide, a 5‐HT 1 and 5‐HT 2 receptor antagonist, and found that methysergide significantly blocked the anxiolytic effects of Kiss1 in the presence of the AS ( p < 0.001). From this, we conclude that Kiss1 modulates AS‐evoked fear responses mediated by the 5‐HT 1A and 5‐HT 2 receptors. image Kiss1 peptide intracranially (IC) administrated has been shown to decrease olfactory, alarm substance (AS)‐evoked fear response. Blockade of the 5‐HT 1A receptor utilizing WAY 100635 (0.28 mg/kg) and the 5‐HT 1 and 5‐HT 2 receptor utilizing methysergide (92.79 mg/kg) produced increased AS‐evoked fear responses that were unable to be overcome even during the recovery period. Blockade of this 5‐HT system followed by Kiss1 administration showed that the peptide was unable to recover the anxiolytic effects upon 5‐HT 1A blocking using WAY 100635 with the exception of freezing behaviour while methysergide significantly blocked all the anxiolytic effects of Kiss1. These findings implicate that Kiss1 could modulate AS‐evoked fear responses mediated by 5‐HT 1A and 5‐HT 2 receptors." @default.
• W2020486987 created "2016-06-24" @default.
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• W2020486987 date "2015-04-17" @default.
• W2020486987 modified "2023-10-16" @default.
• W2020486987 title "Kisspeptin1 modulates odorant-evoked fear response via two serotonin receptor subtypes (5-HT_1A and 5-HT₂ ) in zebrafish" @default.
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• W2020486987 doi "https://doi.org/10.1111/jnc.13105" @default.
• W2020486987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25818845" @default.
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