FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020491471> ?p ?o ?g. }

• W2020491471 endingPage "35" @default.
• W2020491471 startingPage "28" @default.
• W2020491471 abstract "ObjectiveTo investigate the graft-vs-leukemia effect of allogeneic stem cell transplantation after a nonablative conditioning regimen as treatment for patients with chronic lymphocytic leukemia.Patients and MethodsPatients were eligible to treatment if they were refractory or recurred after a prior response to fludarabine. Seventeen patients were treated. All patients received a preparative regimen of fludarabine (30 mg/m2 daily for 3 days) and intravenous cyclophosphamide (750 mg/m2 daily for 3 days). Ten patients received rituximab in addition to chemotherapy. The median time from diagnosis to transplant was 67 months. Nine of 17 patients had refractory disease.ResultsAll patients had engraftment of donor cells. Eleven (65%) did not require platelet transfusions. Ten patients with persistent disease underwent immunomanipulation to augment GVL effects including immunosuppression withdrawal and donor lymphocyte infusion with or without rituximab treatment. Seven of these 10 patients had a complete response and 2 had a partial response; 8 of these 9 responders had received rituximab with their immunomanipulation process. The final response was complete remission in 12 and partial remission in 4 patients for an overall response rate of 94%. Overall survival was 100% for patients who received the combined chemo-rituximab conditioning regimen, vs 14% for those who received chemotherapy alone (p = 0.03).ConclusionOur results indicate that a pronounced GVL effect occurs after nonmyeloablative allogeneic hematopoietic transplantation for advanced CLL. This activity might be facilitated by rituximab. Prospective controlled trials are needed to define the role of nonablative allogeneic hematopoietic transplantation for treatment of this disease." @default.
• W2020491471 created "2016-06-24" @default.
• W2020491471 creator A5004417292 @default.
• W2020491471 creator A5020383305 @default.
• W2020491471 creator A5027575595 @default.
• W2020491471 creator A5033381380 @default.
• W2020491471 creator A5033737136 @default.
• W2020491471 creator A5047522685 @default.
• W2020491471 creator A5048913229 @default.
• W2020491471 creator A5050962913 @default.
• W2020491471 creator A5065661042 @default.
• W2020491471 creator A5070096873 @default.
• W2020491471 creator A5073053011 @default.
• W2020491471 creator A5083279961 @default.
• W2020491471 date "2004-01-01" @default.
• W2020491471 modified "2023-10-17" @default.
• W2020491471 title "Nonablative allogeneic stem cell transplantation for chronic lymphocytic leukemia: impact of rituximab on immunomodulation and survival" @default.
• W2020491471 cites W1883328448 @default.
• W2020491471 cites W1942856476 @default.
• W2020491471 cites W1980653650 @default.
• W2020491471 cites W1995176938 @default.
• W2020491471 cites W2002688127 @default.
• W2020491471 cites W2093806889 @default.
• W2020491471 cites W2120351292 @default.
• W2020491471 cites W2128402413 @default.
• W2020491471 cites W2130223796 @default.
• W2020491471 cites W2143749371 @default.
• W2020491471 cites W2154928424 @default.
• W2020491471 cites W2318261848 @default.
• W2020491471 cites W2324177572 @default.
• W2020491471 cites W2334647503 @default.
• W2020491471 cites W4233718653 @default.
• W2020491471 cites W4252684946 @default.
• W2020491471 cites W4293241248 @default.
• W2020491471 cites W60865865 @default.
• W2020491471 doi "https://doi.org/10.1016/j.exphem.2003.09.021" @default.
• W2020491471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14725898" @default.
• W2020491471 hasPublicationYear "2004" @default.
• W2020491471 type Work @default.
• W2020491471 sameAs 2020491471 @default.
• W2020491471 citedByCount "124" @default.
• W2020491471 countsByYear W20204914712012 @default.
• W2020491471 countsByYear W20204914712013 @default.
• W2020491471 countsByYear W20204914712014 @default.
• W2020491471 countsByYear W20204914712015 @default.
• W2020491471 countsByYear W20204914712016 @default.
• W2020491471 countsByYear W20204914712017 @default.
• W2020491471 countsByYear W20204914712018 @default.
• W2020491471 countsByYear W20204914712019 @default.
• W2020491471 crossrefType "journal-article" @default.
• W2020491471 hasAuthorship W2020491471A5004417292 @default.
• W2020491471 hasAuthorship W2020491471A5020383305 @default.
• W2020491471 hasAuthorship W2020491471A5027575595 @default.
• W2020491471 hasAuthorship W2020491471A5033381380 @default.
• W2020491471 hasAuthorship W2020491471A5033737136 @default.
• W2020491471 hasAuthorship W2020491471A5047522685 @default.
• W2020491471 hasAuthorship W2020491471A5048913229 @default.
• W2020491471 hasAuthorship W2020491471A5050962913 @default.
• W2020491471 hasAuthorship W2020491471A5065661042 @default.
• W2020491471 hasAuthorship W2020491471A5070096873 @default.
• W2020491471 hasAuthorship W2020491471A5073053011 @default.
• W2020491471 hasAuthorship W2020491471A5083279961 @default.
• W2020491471 hasBestOaLocation W20204914711 @default.
• W2020491471 hasConcept C121332964 @default.
• W2020491471 hasConcept C126322002 @default.
• W2020491471 hasConcept C141071460 @default.
• W2020491471 hasConcept C142424586 @default.
• W2020491471 hasConcept C203014093 @default.
• W2020491471 hasConcept C2776694085 @default.
• W2020491471 hasConcept C2776755627 @default.
• W2020491471 hasConcept C2777408962 @default.
• W2020491471 hasConcept C2777938653 @default.
• W2020491471 hasConcept C2778461978 @default.
• W2020491471 hasConcept C2779263901 @default.
• W2020491471 hasConcept C2779338263 @default.
• W2020491471 hasConcept C2779695342 @default.
• W2020491471 hasConcept C2780252810 @default.
• W2020491471 hasConcept C2780653079 @default.
• W2020491471 hasConcept C2781413609 @default.
• W2020491471 hasConcept C2911091166 @default.
• W2020491471 hasConcept C71924100 @default.
• W2020491471 hasConcept C87355193 @default.
• W2020491471 hasConcept C90924648 @default.
• W2020491471 hasConceptScore W2020491471C121332964 @default.
• W2020491471 hasConceptScore W2020491471C126322002 @default.
• W2020491471 hasConceptScore W2020491471C141071460 @default.
• W2020491471 hasConceptScore W2020491471C142424586 @default.
• W2020491471 hasConceptScore W2020491471C203014093 @default.
• W2020491471 hasConceptScore W2020491471C2776694085 @default.
• W2020491471 hasConceptScore W2020491471C2776755627 @default.
• W2020491471 hasConceptScore W2020491471C2777408962 @default.
• W2020491471 hasConceptScore W2020491471C2777938653 @default.
• W2020491471 hasConceptScore W2020491471C2778461978 @default.
• W2020491471 hasConceptScore W2020491471C2779263901 @default.
• W2020491471 hasConceptScore W2020491471C2779338263 @default.
• W2020491471 hasConceptScore W2020491471C2779695342 @default.
• W2020491471 hasConceptScore W2020491471C2780252810 @default.
• W2020491471 hasConceptScore W2020491471C2780653079 @default.

• next