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• W2020494412 abstract "Carcinoma cells frequently invade the surrounding tissue as coherent clusters or nests of cells. We have called this type of movement “cohort migration.” We have previously presented an in vitro two-dimensional cohort migration model, in which highly metastatic variant L-10 cells of human rectal adenocarcinoma cell line RCM-1 moved as coherent cell sheets when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or hepatocyte growth factor/scatter factor (HGF/SF). Pericellular deposition of EDA-containing fibronectin (EDA+FN) was essential for TPA-induced cohort migration. In this study, we investigated how colon-derived fibroblasts could affect the induction of cohort migration of colorectal carcinoma cells by HGF/SF, since carcinoma cell-fibroblast interactions frequently regulate biological events during cancer cell invasion. Fibroblasts co-cultured with L-10 carcinoma cells stimulated HGF/SF-induced cohort migration of L-10 cells up to 2 to 3-fold. Conditioned medium (CM) from fibroblasts that were cultured alone was not effective but CM from fibroblasts cocultured with carcinoma cells enhanced HGF/SF-induced cohort migration, and this effect in CM was found to be mediated by TGF-β1 upregulated in co-cultured conditions. Among the motogenic growth factors examined, only TGF-β1 synergistically stimulated HGF/SF-induced L-10 cell cohort migration, although TGF-β1 alone did not induce cohort migration. TGF-β1 also exhibited synergistic effect in several other human colorectal carcinoma cell lines. The synergistic stimulation of L-10 cell cohort migration by HGF/SF and TGF-β1 was associated with increased production of motility-enhancing EDA+FN by L-10 cells, and blocking FN with a specific antibody effectively inhibited the synergistic effect. Int. J. Cancer 82:449–458, 1999. © 1999 Wiley-Liss, Inc." @default.
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• W2020494412 date "1999-07-30" @default.
• W2020494412 modified "2023-09-26" @default.
• W2020494412 title "Role of fibroblasts in HGF/SF-induced cohort migration of human colorectal carcinoma cells: Fibroblasts stimulate migration associated with increased fibronectin production via upregulated TGF-?1" @default.
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• W2020494412 doi "https://doi.org/10.1002/(sici)1097-0215(19990730)82:3<449::aid-ijc20>3.0.co;2-h" @default.
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