FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020508768> ?p ?o ?g. }

• W2020508768 endingPage "379" @default.
• W2020508768 startingPage "373" @default.
• W2020508768 abstract "Discerning the pathologic significance of cutaneous T-cell infiltrates can pose a diagnostic challenge for dermatopathologists. Reactive conditions such as drug-associated lymphomatoid hypersensitivity and lymphomatoid lupus erythematosus can demonstrate lymphoid atypia and a phenotype resembling cutaneous T-cell lymphoma (CTCL). Further, lymphoid dyscrasias such as pityriasis lichenoides chronica, large plaque parapsoriasis, and atypical pigmentary purpura confuse the picture because they not only mimic CTCL but also represent prelymphomatous states with inherent malignant potential. Although the emergence of a dominant clone has been considered a clue indicative of a T-cell dyscrasia, there are reports concerning the identification of monoclonality in biopsies of reactive lymphoid infiltrates. We have conducted a modified single-stranded DNA conformational polymorphism (SSCP) assay using paraffin-embedded, formalin-fixed tissue on 92 T-cell–rich biopsies to determine the relative specificity and sensitivity of this methodology. In addition, laser capture microdissection (LCM) was performed on 22 of the 92 samples to isolate the area of interest and to compare its specificity and sensitivity with those SSCP assays performed without LCM. We found that monoclonality or oligoclonality is 86% specific for preneoplastic and neoplastic states, whereas the finding of polyclonality appears to be relatively specific for a reactive process. Some cases of reversible T-cell dyscrasia produced a molecular profile mimicking lymphoma or prelymphomatous states by virtue of monoclonality or oligoclonality. Although LCM appears to improve the sensitivity for detecting preneoplastic conditions, the relative specificity appears to be the same as that encountered with routine SSCP." @default.
• W2020508768 created "2016-06-24" @default.
• W2020508768 creator A5001884070 @default.
• W2020508768 creator A5003584389 @default.
• W2020508768 creator A5014400330 @default.
• W2020508768 creator A5032754992 @default.
• W2020508768 creator A5043014546 @default.
• W2020508768 creator A5051875406 @default.
• W2020508768 creator A5059394561 @default.
• W2020508768 creator A5064411755 @default.
• W2020508768 creator A5068234675 @default.
• W2020508768 creator A5069148100 @default.
• W2020508768 date "2004-12-01" @default.
• W2020508768 modified "2023-10-17" @default.
• W2020508768 title "Assessment of T-cell Clonality via T-cell Receptor-γ Rearrangements in Cutaneous T-cell–Dominant Infiltrates Using Polymerase Chain Reaction and Single-stranded DNA Conformational Polymorphism Assay" @default.
• W2020508768 cites W1579692268 @default.
• W2020508768 cites W1602230426 @default.
• W2020508768 cites W1965790014 @default.
• W2020508768 cites W1967591620 @default.
• W2020508768 cites W1978952142 @default.
• W2020508768 cites W1986140906 @default.
• W2020508768 cites W1987234885 @default.
• W2020508768 cites W1993895098 @default.
• W2020508768 cites W2000565662 @default.
• W2020508768 cites W2001729554 @default.
• W2020508768 cites W2022341531 @default.
• W2020508768 cites W2028085350 @default.
• W2020508768 cites W2034470269 @default.
• W2020508768 cites W2043350818 @default.
• W2020508768 cites W2048804042 @default.
• W2020508768 cites W2051109147 @default.
• W2020508768 cites W2064487212 @default.
• W2020508768 cites W2072812359 @default.
• W2020508768 cites W2114233858 @default.
• W2020508768 cites W2119417499 @default.
• W2020508768 cites W2121909431 @default.
• W2020508768 cites W2150740204 @default.
• W2020508768 cites W4251362004 @default.
• W2020508768 doi "https://doi.org/10.1097/00129039-200412000-00016" @default.
• W2020508768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15536341" @default.
• W2020508768 hasPublicationYear "2004" @default.
• W2020508768 type Work @default.
• W2020508768 sameAs 2020508768 @default.
• W2020508768 citedByCount "26" @default.
• W2020508768 countsByYear W20205087682012 @default.
• W2020508768 countsByYear W20205087682013 @default.
• W2020508768 countsByYear W20205087682014 @default.
• W2020508768 countsByYear W20205087682016 @default.
• W2020508768 countsByYear W20205087682018 @default.
• W2020508768 countsByYear W20205087682021 @default.
• W2020508768 crossrefType "journal-article" @default.
• W2020508768 hasAuthorship W2020508768A5001884070 @default.
• W2020508768 hasAuthorship W2020508768A5003584389 @default.
• W2020508768 hasAuthorship W2020508768A5014400330 @default.
• W2020508768 hasAuthorship W2020508768A5032754992 @default.
• W2020508768 hasAuthorship W2020508768A5043014546 @default.
• W2020508768 hasAuthorship W2020508768A5051875406 @default.
• W2020508768 hasAuthorship W2020508768A5059394561 @default.
• W2020508768 hasAuthorship W2020508768A5064411755 @default.
• W2020508768 hasAuthorship W2020508768A5068234675 @default.
• W2020508768 hasAuthorship W2020508768A5069148100 @default.
• W2020508768 hasConcept C104317684 @default.
• W2020508768 hasConcept C129219603 @default.
• W2020508768 hasConcept C142724271 @default.
• W2020508768 hasConcept C153911025 @default.
• W2020508768 hasConcept C203014093 @default.
• W2020508768 hasConcept C2776090121 @default.
• W2020508768 hasConcept C2776780870 @default.
• W2020508768 hasConcept C2777073666 @default.
• W2020508768 hasConcept C2777182591 @default.
• W2020508768 hasConcept C2777756187 @default.
• W2020508768 hasConcept C2779338263 @default.
• W2020508768 hasConcept C2780954659 @default.
• W2020508768 hasConcept C49105822 @default.
• W2020508768 hasConcept C54355233 @default.
• W2020508768 hasConcept C71924100 @default.
• W2020508768 hasConcept C86803240 @default.
• W2020508768 hasConcept C8891405 @default.
• W2020508768 hasConceptScore W2020508768C104317684 @default.
• W2020508768 hasConceptScore W2020508768C129219603 @default.
• W2020508768 hasConceptScore W2020508768C142724271 @default.
• W2020508768 hasConceptScore W2020508768C153911025 @default.
• W2020508768 hasConceptScore W2020508768C203014093 @default.
• W2020508768 hasConceptScore W2020508768C2776090121 @default.
• W2020508768 hasConceptScore W2020508768C2776780870 @default.
• W2020508768 hasConceptScore W2020508768C2777073666 @default.
• W2020508768 hasConceptScore W2020508768C2777182591 @default.
• W2020508768 hasConceptScore W2020508768C2777756187 @default.
• W2020508768 hasConceptScore W2020508768C2779338263 @default.
• W2020508768 hasConceptScore W2020508768C2780954659 @default.
• W2020508768 hasConceptScore W2020508768C49105822 @default.
• W2020508768 hasConceptScore W2020508768C54355233 @default.
• W2020508768 hasConceptScore W2020508768C71924100 @default.
• W2020508768 hasConceptScore W2020508768C86803240 @default.
• W2020508768 hasConceptScore W2020508768C8891405 @default.
• W2020508768 hasIssue "4" @default.
• W2020508768 hasLocation W20205087681 @default.
• W2020508768 hasLocation W20205087682 @default.

• next