Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020512376> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2020512376 endingPage "232" @default.
- W2020512376 startingPage "229" @default.
- W2020512376 abstract "Some chronic pain patients on long-term opioid therapy also take centrally active skeletal muscle relaxants. One of those muscle relaxants is carisoprodol, a drug that is abused and capable of producing impairment. It would be of relevance to characterize the effects of an opioid and carisoprodol when taken together to determine if abuse liability-related measures and psychomotor impairment are increased compared to when the drugs are taken alone. As part of a larger crossover, randomized, double-blind study, we examined the subjective and psychomotor responses of 15 healthy volunteers to four experimental conditions: placebo, 350 mg carisoprodol, 10 mg oxycodone, and 350 mg carisoprodol followed 60 min later by 10 mg oxycodone (intended to test the interaction of the two drugs when they were producing their maximal effects). Preliminary data analyses indicated that some of carisoprodol's effects were declining when we tested for drug interactions. Despite this, on some outcome measures in which the drugs alone did not differ from placebo, when tested together subjective effects were increased, including those that were abuse liability-related, and psychomotor performance decreased, relative to placebo. This is the first study that we are aware of that has shown that carisoprodol and oxycodone, two drugs that are sometimes co-prescribed for relief of pain, produce effects when administered “together” (i.e., separated by 60 min) that are of greater magnitude than when they are administered alone. Some of the effects were not benign, and are of concern from both abuse liability and public safety standpoints." @default.
- W2020512376 created "2016-06-24" @default.
- W2020512376 creator A5007309115 @default.
- W2020512376 creator A5012038009 @default.
- W2020512376 creator A5013181722 @default.
- W2020512376 date "2012-01-01" @default.
- W2020512376 modified "2023-09-25" @default.
- W2020512376 title "Subjective and psychomotor effects of carisoprodol in combination with oxycodone in healthy volunteers" @default.
- W2020512376 cites W1508296484 @default.
- W2020512376 cites W1980507990 @default.
- W2020512376 cites W1994458277 @default.
- W2020512376 cites W2012981598 @default.
- W2020512376 cites W2027022038 @default.
- W2020512376 cites W2027484675 @default.
- W2020512376 cites W2029277236 @default.
- W2020512376 cites W2045112592 @default.
- W2020512376 cites W2073371304 @default.
- W2020512376 cites W2073889366 @default.
- W2020512376 cites W2111384889 @default.
- W2020512376 cites W2138263881 @default.
- W2020512376 cites W2165759090 @default.
- W2020512376 cites W54728729 @default.
- W2020512376 doi "https://doi.org/10.1016/j.drugalcdep.2011.07.006" @default.
- W2020512376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3240720" @default.
- W2020512376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21840651" @default.
- W2020512376 hasPublicationYear "2012" @default.
- W2020512376 type Work @default.
- W2020512376 sameAs 2020512376 @default.
- W2020512376 citedByCount "11" @default.
- W2020512376 countsByYear W20205123762012 @default.
- W2020512376 countsByYear W20205123762014 @default.
- W2020512376 countsByYear W20205123762015 @default.
- W2020512376 countsByYear W20205123762016 @default.
- W2020512376 countsByYear W20205123762017 @default.
- W2020512376 countsByYear W20205123762019 @default.
- W2020512376 crossrefType "journal-article" @default.
- W2020512376 hasAuthorship W2020512376A5007309115 @default.
- W2020512376 hasAuthorship W2020512376A5012038009 @default.
- W2020512376 hasAuthorship W2020512376A5013181722 @default.
- W2020512376 hasBestOaLocation W20205123762 @default.
- W2020512376 hasConcept C118552586 @default.
- W2020512376 hasConcept C126322002 @default.
- W2020512376 hasConcept C142724271 @default.
- W2020512376 hasConcept C15744967 @default.
- W2020512376 hasConcept C164953862 @default.
- W2020512376 hasConcept C169900460 @default.
- W2020512376 hasConcept C170493617 @default.
- W2020512376 hasConcept C194828623 @default.
- W2020512376 hasConcept C204787440 @default.
- W2020512376 hasConcept C27081682 @default.
- W2020512376 hasConcept C2776029756 @default.
- W2020512376 hasConcept C2776860028 @default.
- W2020512376 hasConcept C2781063702 @default.
- W2020512376 hasConcept C3017944768 @default.
- W2020512376 hasConcept C42219234 @default.
- W2020512376 hasConcept C71924100 @default.
- W2020512376 hasConcept C87813604 @default.
- W2020512376 hasConceptScore W2020512376C118552586 @default.
- W2020512376 hasConceptScore W2020512376C126322002 @default.
- W2020512376 hasConceptScore W2020512376C142724271 @default.
- W2020512376 hasConceptScore W2020512376C15744967 @default.
- W2020512376 hasConceptScore W2020512376C164953862 @default.
- W2020512376 hasConceptScore W2020512376C169900460 @default.
- W2020512376 hasConceptScore W2020512376C170493617 @default.
- W2020512376 hasConceptScore W2020512376C194828623 @default.
- W2020512376 hasConceptScore W2020512376C204787440 @default.
- W2020512376 hasConceptScore W2020512376C27081682 @default.
- W2020512376 hasConceptScore W2020512376C2776029756 @default.
- W2020512376 hasConceptScore W2020512376C2776860028 @default.
- W2020512376 hasConceptScore W2020512376C2781063702 @default.
- W2020512376 hasConceptScore W2020512376C3017944768 @default.
- W2020512376 hasConceptScore W2020512376C42219234 @default.
- W2020512376 hasConceptScore W2020512376C71924100 @default.
- W2020512376 hasConceptScore W2020512376C87813604 @default.
- W2020512376 hasIssue "1-3" @default.
- W2020512376 hasLocation W20205123761 @default.
- W2020512376 hasLocation W20205123762 @default.
- W2020512376 hasLocation W20205123763 @default.
- W2020512376 hasLocation W20205123764 @default.
- W2020512376 hasOpenAccess W2020512376 @default.
- W2020512376 hasPrimaryLocation W20205123761 @default.
- W2020512376 hasRelatedWork W2008627275 @default.
- W2020512376 hasRelatedWork W2020512376 @default.
- W2020512376 hasRelatedWork W2078394078 @default.
- W2020512376 hasRelatedWork W2092901098 @default.
- W2020512376 hasRelatedWork W2172262068 @default.
- W2020512376 hasRelatedWork W2362169642 @default.
- W2020512376 hasRelatedWork W2975876581 @default.
- W2020512376 hasRelatedWork W3185240436 @default.
- W2020512376 hasRelatedWork W4220785758 @default.
- W2020512376 hasRelatedWork W4318917480 @default.
- W2020512376 hasVolume "120" @default.
- W2020512376 isParatext "false" @default.
- W2020512376 isRetracted "false" @default.
- W2020512376 magId "2020512376" @default.
- W2020512376 workType "article" @default.