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• W2020528945 startingPage "603" @default.
• W2020528945 abstract "Although studies have shown alterations in cerebral metabolism after traumatic brain injury (TBI), clinical data in the developing brain is limited. We hypothesized that post-traumatic metabolic changes occur early (<24 h) and persist for up to 1 week. Immature rats underwent TBI to the left parietal cortex. Brains were removed at 4 h, 24 h, and 7 days after injury, and separated into ipsilateral (injured) and contralateral (control) hemispheres. Proton nuclear magnetic resonance (NMR) spectra were obtained, and spectra were analyzed for N-acetyl-aspartate (NAA), lactate (Lac), creatine (Cr), choline, and alanine, with metabolite ratios determined (NAA/Cr, Lac/Cr). There were no metabolic differences at any time in sham controls between cerebral hemispheres. At 4 and 24 h, there was an increase in Lac/Cr, reflecting increased glycolysis and/or decreased oxidative metabolism. At 24 h and 7 days, there was a decrease in NAA/Cr, indicating loss of neuronal integrity. The NAA/Lac ratio was decreased (∼15–20%) at all times (4 h, 24 h, 7 days) in the injured hemisphere of TBI rats. In conclusion, metabolic derangements begin early (<24 h) after TBI in the immature rat and are sustained for up to 7 days. Evaluation of early metabolic alterations after TBI could identify novel targets for neuroprotection in the developing brain." @default.
• W2020528945 created "2016-06-24" @default.
• W2020528945 creator A5019892478 @default.
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• W2020528945 date "2008-06-01" @default.
• W2020528945 modified "2023-10-18" @default.
• W2020528945 title "Early and Sustained Alterations in Cerebral Metabolism after Traumatic Brain Injury in Immature Rats" @default.
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• W2020528945 doi "https://doi.org/10.1089/neu.2007.0481" @default.
• W2020528945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2946869" @default.
• W2020528945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18454682" @default.
• W2020528945 hasPublicationYear "2008" @default.
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