Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020529419> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2020529419 endingPage "27" @default.
- W2020529419 startingPage "22" @default.
- W2020529419 abstract "A simple, rapid and selective method was developed for the estimation of amlodipine from human plasma. The method involves a simple protein precipitation techniques using nifedipine as internal standard. Chromatographic separa- tion was carried out on a reverse phase C18 column using mixture of 50 mM potassium di hydrogen ortho phosphate (pH 7.5) and acetonitrile (60:40, v/v) at a flow rate of 1.0 mL/min with UV detection at 239 nm. The retention time of am- lodipine and internal standard were 4.12 and 8.31min, respectively. The method was validated and found to be linear in the range of 0.5-50.0 ng/mL. An open, randomized, two-treatment, two period, single dose crossover, bioequivalence study in 24 fasting, healthy, male, volunteers was conducted. After dosing, serial blood samples were collected for the pe- riod of 168.0 h. Various pharmacokinetic parameters including AUC0-t, AUC0-�, Cmax, Tmax, T1/2, and elimination rate constant (Kel) were determined from plasma concentration of both formulations of test (Amlodipine 5 mg tablets) and ref- erence (Amlodipine 5 mg tablets). Log transformed values were compared by analysis of variance (ANOVA) followed by classical 90% confidence interval for Cmax, AUC0-t and AUC0-� and was found to be within the range. These results indi- cated that the analytical method was linear, precise and accurate. Test and reference formulation were found to be bioe- quivalent." @default.
- W2020529419 created "2016-06-24" @default.
- W2020529419 creator A5027698538 @default.
- W2020529419 creator A5045423141 @default.
- W2020529419 creator A5060553627 @default.
- W2020529419 creator A5082204659 @default.
- W2020529419 creator A5086443933 @default.
- W2020529419 date "2008-09-26" @default.
- W2020529419 modified "2023-10-18" @default.
- W2020529419 title "A Simple Sample Preparation with HPLC - UV Method for Estimation of Amlodipine from Plasma: Application to Bioequivalence Study" @default.
- W2020529419 doi "https://doi.org/10.2174/1875038900801010022" @default.
- W2020529419 hasPublicationYear "2008" @default.
- W2020529419 type Work @default.
- W2020529419 sameAs 2020529419 @default.
- W2020529419 citedByCount "16" @default.
- W2020529419 countsByYear W20205294192012 @default.
- W2020529419 countsByYear W20205294192013 @default.
- W2020529419 countsByYear W20205294192014 @default.
- W2020529419 countsByYear W20205294192016 @default.
- W2020529419 countsByYear W20205294192020 @default.
- W2020529419 countsByYear W20205294192023 @default.
- W2020529419 crossrefType "journal-article" @default.
- W2020529419 hasAuthorship W2020529419A5027698538 @default.
- W2020529419 hasAuthorship W2020529419A5045423141 @default.
- W2020529419 hasAuthorship W2020529419A5060553627 @default.
- W2020529419 hasAuthorship W2020529419A5082204659 @default.
- W2020529419 hasAuthorship W2020529419A5086443933 @default.
- W2020529419 hasBestOaLocation W20205294191 @default.
- W2020529419 hasConcept C111472728 @default.
- W2020529419 hasConcept C121332964 @default.
- W2020529419 hasConcept C126322002 @default.
- W2020529419 hasConcept C138885662 @default.
- W2020529419 hasConcept C179998833 @default.
- W2020529419 hasConcept C181389837 @default.
- W2020529419 hasConcept C185592680 @default.
- W2020529419 hasConcept C198531522 @default.
- W2020529419 hasConcept C2778576202 @default.
- W2020529419 hasConcept C2779646130 @default.
- W2020529419 hasConcept C2780586882 @default.
- W2020529419 hasConcept C3020079912 @default.
- W2020529419 hasConcept C33923547 @default.
- W2020529419 hasConcept C41008148 @default.
- W2020529419 hasConcept C42404028 @default.
- W2020529419 hasConcept C43617362 @default.
- W2020529419 hasConcept C62520636 @default.
- W2020529419 hasConcept C71924100 @default.
- W2020529419 hasConcept C82706917 @default.
- W2020529419 hasConcept C84393581 @default.
- W2020529419 hasConcept C98274493 @default.
- W2020529419 hasConceptScore W2020529419C111472728 @default.
- W2020529419 hasConceptScore W2020529419C121332964 @default.
- W2020529419 hasConceptScore W2020529419C126322002 @default.
- W2020529419 hasConceptScore W2020529419C138885662 @default.
- W2020529419 hasConceptScore W2020529419C179998833 @default.
- W2020529419 hasConceptScore W2020529419C181389837 @default.
- W2020529419 hasConceptScore W2020529419C185592680 @default.
- W2020529419 hasConceptScore W2020529419C198531522 @default.
- W2020529419 hasConceptScore W2020529419C2778576202 @default.
- W2020529419 hasConceptScore W2020529419C2779646130 @default.
- W2020529419 hasConceptScore W2020529419C2780586882 @default.
- W2020529419 hasConceptScore W2020529419C3020079912 @default.
- W2020529419 hasConceptScore W2020529419C33923547 @default.
- W2020529419 hasConceptScore W2020529419C41008148 @default.
- W2020529419 hasConceptScore W2020529419C42404028 @default.
- W2020529419 hasConceptScore W2020529419C43617362 @default.
- W2020529419 hasConceptScore W2020529419C62520636 @default.
- W2020529419 hasConceptScore W2020529419C71924100 @default.
- W2020529419 hasConceptScore W2020529419C82706917 @default.
- W2020529419 hasConceptScore W2020529419C84393581 @default.
- W2020529419 hasConceptScore W2020529419C98274493 @default.
- W2020529419 hasIssue "1" @default.
- W2020529419 hasLocation W20205294191 @default.
- W2020529419 hasOpenAccess W2020529419 @default.
- W2020529419 hasPrimaryLocation W20205294191 @default.
- W2020529419 hasRelatedWork W1976239853 @default.
- W2020529419 hasRelatedWork W2009010999 @default.
- W2020529419 hasRelatedWork W2013763699 @default.
- W2020529419 hasRelatedWork W2015355492 @default.
- W2020529419 hasRelatedWork W2093342723 @default.
- W2020529419 hasRelatedWork W2143030322 @default.
- W2020529419 hasRelatedWork W2361141970 @default.
- W2020529419 hasRelatedWork W2383415077 @default.
- W2020529419 hasRelatedWork W253484456 @default.
- W2020529419 hasRelatedWork W2606965854 @default.
- W2020529419 hasVolume "1" @default.
- W2020529419 isParatext "false" @default.
- W2020529419 isRetracted "false" @default.
- W2020529419 magId "2020529419" @default.
- W2020529419 workType "article" @default.