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• W2020530044 endingPage "1308" @default.
• W2020530044 startingPage "1296" @default.
• W2020530044 abstract "Adipocyte dysfunction is associated with many metabolic diseases such as obesity, insulin resistance and diabetes. Previous studies found that phloretin promotes 3T3-L1 cells differentiation, but the underlying mechanisms for phloretin's effects on adipogenesis remain unclear. In this study, we demonstrated that phloretin enhanced the lipid accumulation in porcine primary adipocytes in a time-dependent manner. Furthermore, phloretin increased the utilization of glucose and nonesterified fatty acid, while it decreased the lactate output. Microarray analysis revealed that genes associated with peroxisome proliferator-activated receptor-γ (PPARγ), mitogen-activated protein kinase and insulin signaling pathways were altered in response to phloretin. We further confirmed that phloretin enhanced expression of PPARγ, CAAT enhancer binding protein-α (C/EBPα) and adipose-related genes, such as fatty acids translocase and fatty acid synthase. In addition, phloretin activated the Akt (Thr308) and extracellular signal-regulated kinase, and therefore, inactivated Akt targets protein. Wortmannin effectively blocked the effect of phloretin on Akt activity and the protein levels of PPARγ, C/EBPα and fatty acid binding protein-4 (FABP4/aP2). Oral administration of 5 or 10 mg/kg phloretin to C57BL BKS-DB mice significantly decreased the serum glucose level and improved glucose tolerance. In conclusion, phloretin promotes the adipogenesis of porcine primary preadipocytes through Akt-associated signaling pathway. These findings suggested that phloretin might be able to increase insulin sensitivity and alleviate the metabolic diseases." @default.
• W2020530044 created "2016-06-24" @default.
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• W2020530044 date "2014-12-01" @default.
• W2020530044 modified "2023-10-17" @default.
• W2020530044 title "Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo" @default.
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• W2020530044 cites W1549631663 @default.
• W2020530044 cites W1584637627 @default.
• W2020530044 cites W1907219612 @default.
• W2020530044 cites W1929364878 @default.
• W2020530044 cites W1966041510 @default.
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• W2020530044 cites W1978551433 @default.
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• W2020530044 cites W2001331104 @default.
• W2020530044 cites W2001604240 @default.
• W2020530044 cites W2011801069 @default.
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• W2020530044 cites W2016612191 @default.
• W2020530044 cites W2028658648 @default.
• W2020530044 cites W2033762238 @default.
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• W2020530044 cites W2040059770 @default.
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• W2020530044 cites W2129133439 @default.
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• W2020530044 cites W2135778926 @default.
• W2020530044 cites W2137035181 @default.
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• W2020530044 doi "https://doi.org/10.1016/j.jnutbio.2014.07.007" @default.
• W2020530044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25283330" @default.
• W2020530044 hasPublicationYear "2014" @default.
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