Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020532844> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2020532844 endingPage "55" @default.
- W2020532844 startingPage "48" @default.
- W2020532844 abstract "Aim: The purpose of this study was to evaluate the efficacy and safety of LIVALO® tablets (pitavastatin) in Japanese male children with heterozygous familial hypercholesterolemia (FH).Methods: A multicenter, randomized, double-blind, parallel study was conducted in 14 male children 10-15 years of age with heterozygous FH. Pitavastatin (1 mg/day or 2 mg/day) was administered orally for 52 weeks.The primary endpoint was the percent change in the LDL-cholesterol (LDL-C) concentrations from baseline to endpoint (repeated measures ANCOVA at Weeks 8 and 12). Secondary endpoints included the percentage of patients who achieved the target LDL-C concentration and percent changes in the levels of lipoprotein and lipid parameters at the visit performed at 52 weeks.Results: The percent change in LDL-C from baseline (mean 258 mg/dL for all patients) to the endpoint was －27.3% (95%CI; －34.0, －20.5) and －34.3% (95%CI; －41.0, －27.5) in the patients receiving 1 mg and 2 mg of pitavastatin, respectively. Stable reductions in the total cholesterol (TC), non-HDL cholesterol (non-HDL-C), apolipoprotein B (Apo-B) and LDL-C levels and non-HDL-C/HDL-C and Apo-B/Apo-A1 ratios were observed up to 52 weeks in both groups. One patient in each dose group (14%) reached the treatment target level of 130 mg/dL.Adverse events were observed in seven (100%) patients receiving 1 mg and five (71%) patients receiving 2 mg of pitavastatin, although none were considered related to the study treatment. One patient in the 1 mg group reported a musculoskeletal AE; however, it was attributed to recent excessive exercise.Conclusions: Pitavastatin significantly reduced the LDL-C levels and was well tolerated when administered at usual adult doses in 14 male children 10-15 years of age with heterozygous FH. Pitavastatin is a promising therapeutic agent for pediatric dyslipidemia with few safety concerns." @default.
- W2020532844 created "2016-06-24" @default.
- W2020532844 creator A5012076071 @default.
- W2020532844 creator A5025092717 @default.
- W2020532844 creator A5028322843 @default.
- W2020532844 creator A5028921297 @default.
- W2020532844 creator A5048936153 @default.
- W2020532844 date "2016-01-01" @default.
- W2020532844 modified "2023-10-16" @default.
- W2020532844 title "Efficacy and Safety of Pitavastatin in Japanese Male Children with Familial Hypercholesterolemia" @default.
- W2020532844 cites W1485967434 @default.
- W2020532844 cites W1987744412 @default.
- W2020532844 cites W2033796658 @default.
- W2020532844 cites W2036015501 @default.
- W2020532844 cites W2082252581 @default.
- W2020532844 cites W2085646712 @default.
- W2020532844 cites W2262354148 @default.
- W2020532844 cites W4234871431 @default.
- W2020532844 doi "https://doi.org/10.5551/jat.28753" @default.
- W2020532844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25891210" @default.
- W2020532844 hasPublicationYear "2016" @default.
- W2020532844 type Work @default.
- W2020532844 sameAs 2020532844 @default.
- W2020532844 citedByCount "13" @default.
- W2020532844 countsByYear W20205328442016 @default.
- W2020532844 countsByYear W20205328442017 @default.
- W2020532844 countsByYear W20205328442018 @default.
- W2020532844 countsByYear W20205328442020 @default.
- W2020532844 countsByYear W20205328442021 @default.
- W2020532844 countsByYear W20205328442023 @default.
- W2020532844 crossrefType "journal-article" @default.
- W2020532844 hasAuthorship W2020532844A5012076071 @default.
- W2020532844 hasAuthorship W2020532844A5025092717 @default.
- W2020532844 hasAuthorship W2020532844A5028322843 @default.
- W2020532844 hasAuthorship W2020532844A5028921297 @default.
- W2020532844 hasAuthorship W2020532844A5048936153 @default.
- W2020532844 hasBestOaLocation W20205328441 @default.
- W2020532844 hasConcept C126322002 @default.
- W2020532844 hasConcept C134018914 @default.
- W2020532844 hasConcept C168563851 @default.
- W2020532844 hasConcept C197934379 @default.
- W2020532844 hasConcept C203092338 @default.
- W2020532844 hasConcept C2776692505 @default.
- W2020532844 hasConcept C2776839432 @default.
- W2020532844 hasConcept C2778163477 @default.
- W2020532844 hasConcept C2779120738 @default.
- W2020532844 hasConcept C62746215 @default.
- W2020532844 hasConcept C71924100 @default.
- W2020532844 hasConcept C90924648 @default.
- W2020532844 hasConceptScore W2020532844C126322002 @default.
- W2020532844 hasConceptScore W2020532844C134018914 @default.
- W2020532844 hasConceptScore W2020532844C168563851 @default.
- W2020532844 hasConceptScore W2020532844C197934379 @default.
- W2020532844 hasConceptScore W2020532844C203092338 @default.
- W2020532844 hasConceptScore W2020532844C2776692505 @default.
- W2020532844 hasConceptScore W2020532844C2776839432 @default.
- W2020532844 hasConceptScore W2020532844C2778163477 @default.
- W2020532844 hasConceptScore W2020532844C2779120738 @default.
- W2020532844 hasConceptScore W2020532844C62746215 @default.
- W2020532844 hasConceptScore W2020532844C71924100 @default.
- W2020532844 hasConceptScore W2020532844C90924648 @default.
- W2020532844 hasIssue "1" @default.
- W2020532844 hasLocation W20205328441 @default.
- W2020532844 hasLocation W20205328442 @default.
- W2020532844 hasOpenAccess W2020532844 @default.
- W2020532844 hasPrimaryLocation W20205328441 @default.
- W2020532844 hasRelatedWork W1981345773 @default.
- W2020532844 hasRelatedWork W2020532844 @default.
- W2020532844 hasRelatedWork W2025648868 @default.
- W2020532844 hasRelatedWork W2026539275 @default.
- W2020532844 hasRelatedWork W2032958076 @default.
- W2020532844 hasRelatedWork W2035331946 @default.
- W2020532844 hasRelatedWork W2039250890 @default.
- W2020532844 hasRelatedWork W2080480575 @default.
- W2020532844 hasRelatedWork W2117255531 @default.
- W2020532844 hasRelatedWork W2166236611 @default.
- W2020532844 hasVolume "23" @default.
- W2020532844 isParatext "false" @default.
- W2020532844 isRetracted "false" @default.
- W2020532844 magId "2020532844" @default.
- W2020532844 workType "article" @default.