Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020538114> ?p ?o ?g. }
- W2020538114 endingPage "371" @default.
- W2020538114 startingPage "359" @default.
- W2020538114 abstract "With an ever-expanding need for reliable therapeutic agents that are highly effective and exhibit minimal deleterious side effects, a greater understanding of the mechanisms underlying G protein-coupled receptor (GPCR) regulation is fundamental. GPCRs comprise more than 30% of all therapeutic drug targets and it is likely that this will only increase as more orphan GPCRs are identified. The past decade has seen a dramatic shift in the prevailing concept of how GPCRs function, in particular the growing acceptance that GPCRs are capable of interacting with one another at a molecular level to form complexes, with significantly different pharmacological properties to their monomeric selves. While the ability of like-receptors to associate and form homodimers raises some interesting mechanistic issues, the possibility that unlike-receptors could heterodimerise in certain tissue types, producing a functionally unique signalling complex that binds specific ligands, provides an invaluable opportunity to refine and redefine pharmacological interventions with greater specificity and efficacy." @default.
- W2020538114 created "2016-06-24" @default.
- W2020538114 creator A5043089393 @default.
- W2020538114 creator A5046439217 @default.
- W2020538114 creator A5066839373 @default.
- W2020538114 date "2008-06-01" @default.
- W2020538114 modified "2023-09-23" @default.
- W2020538114 title "G protein-coupled receptor dimers: Functional consequences, disease states and drug targets" @default.
- W2020538114 cites W1487872499 @default.
- W2020538114 cites W1526835520 @default.
- W2020538114 cites W1545792116 @default.
- W2020538114 cites W1559798894 @default.
- W2020538114 cites W1563194902 @default.
- W2020538114 cites W1571586310 @default.
- W2020538114 cites W1580186561 @default.
- W2020538114 cites W1581425946 @default.
- W2020538114 cites W1590468936 @default.
- W2020538114 cites W1595449036 @default.
- W2020538114 cites W1654156243 @default.
- W2020538114 cites W1669115568 @default.
- W2020538114 cites W1825353903 @default.
- W2020538114 cites W1830962451 @default.
- W2020538114 cites W1852077611 @default.
- W2020538114 cites W1889694848 @default.
- W2020538114 cites W1922502842 @default.
- W2020538114 cites W1935980653 @default.
- W2020538114 cites W1965019797 @default.
- W2020538114 cites W1966021042 @default.
- W2020538114 cites W1967738476 @default.
- W2020538114 cites W1968132261 @default.
- W2020538114 cites W1968943959 @default.
- W2020538114 cites W1969511937 @default.
- W2020538114 cites W1976258716 @default.
- W2020538114 cites W1976805104 @default.
- W2020538114 cites W1982192731 @default.
- W2020538114 cites W1983213766 @default.
- W2020538114 cites W1983982251 @default.
- W2020538114 cites W1984429646 @default.
- W2020538114 cites W1986308794 @default.
- W2020538114 cites W1989467245 @default.
- W2020538114 cites W1991498584 @default.
- W2020538114 cites W1991905632 @default.
- W2020538114 cites W1993655108 @default.
- W2020538114 cites W1993697025 @default.
- W2020538114 cites W1994092331 @default.
- W2020538114 cites W1994511844 @default.
- W2020538114 cites W1997077121 @default.
- W2020538114 cites W1997811592 @default.
- W2020538114 cites W1998074422 @default.
- W2020538114 cites W2000898489 @default.
- W2020538114 cites W2003966981 @default.
- W2020538114 cites W2005019035 @default.
- W2020538114 cites W2005977960 @default.
- W2020538114 cites W2007051067 @default.
- W2020538114 cites W2007149985 @default.
- W2020538114 cites W2007941243 @default.
- W2020538114 cites W2009134620 @default.
- W2020538114 cites W2009823135 @default.
- W2020538114 cites W2010805571 @default.
- W2020538114 cites W2011433597 @default.
- W2020538114 cites W2016315625 @default.
- W2020538114 cites W2019074781 @default.
- W2020538114 cites W2021035723 @default.
- W2020538114 cites W2021100900 @default.
- W2020538114 cites W2021424170 @default.
- W2020538114 cites W2023939486 @default.
- W2020538114 cites W2024474477 @default.
- W2020538114 cites W2024942419 @default.
- W2020538114 cites W2025536856 @default.
- W2020538114 cites W2027591014 @default.
- W2020538114 cites W2028050078 @default.
- W2020538114 cites W2030152049 @default.
- W2020538114 cites W2031951991 @default.
- W2020538114 cites W2032340700 @default.
- W2020538114 cites W2032948018 @default.
- W2020538114 cites W2034224022 @default.
- W2020538114 cites W2034588648 @default.
- W2020538114 cites W2035290373 @default.
- W2020538114 cites W2035995595 @default.
- W2020538114 cites W2039728623 @default.
- W2020538114 cites W2040473339 @default.
- W2020538114 cites W2041138404 @default.
- W2020538114 cites W2043580671 @default.
- W2020538114 cites W2046161078 @default.
- W2020538114 cites W2046290586 @default.
- W2020538114 cites W2047130413 @default.
- W2020538114 cites W2049464937 @default.
- W2020538114 cites W2052387601 @default.
- W2020538114 cites W2054004217 @default.
- W2020538114 cites W2054982830 @default.
- W2020538114 cites W2055672066 @default.
- W2020538114 cites W2056083897 @default.
- W2020538114 cites W2056296363 @default.
- W2020538114 cites W2058124227 @default.
- W2020538114 cites W2058535388 @default.
- W2020538114 cites W2062214351 @default.
- W2020538114 cites W2065185266 @default.
- W2020538114 cites W2066143615 @default.