FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020546557> ?p ?o ?g. }

• W2020546557 endingPage "425" @default.
• W2020546557 startingPage "419" @default.
• W2020546557 abstract "Summary. All‐ trans retinoic acid (ATRA) has been shown to induce differentiation of human acute promyelocytic leukaemia (APL) cells and eventual elimination of the malignant clone. Matrix metalloproteinase‐9 (MMP‐9) is produced by neutrophils and its expression appears to be linked with myeloid cell differentiation. We investigated effects of ATRA on MMP expression in two human myeloid leukaemia cell lines, PL‐21 and NB4. Both cells could differentiate into neutrophils after exposure to ATRA. Both the activity and antigen levels of MMP‐9 were much higher in NB4 cells than in PL‐21 cells. Stimulation with ATRA significantly increased MMP‐9 levels approximately three‐ to fivefold in both PL‐21 and NB4‐conditioned media. MMP‐9 mRNA levels increased in ATRA‐treated cells and was almost in parallel with the increase in MMP‐9 activity, suggesting that ATRA induced MMP‐9 by activating its gene expression. ATRA can induce interleukin 8 (IL‐8) in APL cells. IL‐8, chemokine for neutrophils and a potent inducer of MMP‐9, was also induced by ATRA in PL‐21 cells. However, recombinant IL‐8 did not induce MMP‐9 expression. In addition, a neutralizing antibody against IL‐8 did not inhibit ATRA‐induced MMP‐9 expression in either cell type. These observations suggest that ATRA can induce both MMP‐9 and IL‐8, but IL‐8 is not involved in ATRA‐induced MMP‐9 expression. As MMP‐9 can truncate and activate IL‐8, simultaneous induction of MMP‐9 and IL‐8 by ATRA could activate leucocytes excessively, causing the hyper‐inflammatory events in retinoic acid syndrome." @default.
• W2020546557 created "2016-06-24" @default.
• W2020546557 creator A5004230500 @default.
• W2020546557 creator A5006653971 @default.
• W2020546557 creator A5007616559 @default.
• W2020546557 creator A5007888883 @default.
• W2020546557 creator A5012652636 @default.
• W2020546557 creator A5013342218 @default.
• W2020546557 creator A5030597247 @default.
• W2020546557 creator A5037362999 @default.
• W2020546557 creator A5047706264 @default.
• W2020546557 creator A5079987156 @default.
• W2020546557 date "2002-07-25" @default.
• W2020546557 modified "2023-10-17" @default.
• W2020546557 title "Simultaneous induction of matrix metalloproteinase-9 and interleukin 8 by all-<i>trans</i>retinoic acid in human PL-21 and NB4 myeloid leukaemia cells" @default.
• W2020546557 cites W1490135869 @default.
• W2020546557 cites W1581404300 @default.
• W2020546557 cites W1589900156 @default.
• W2020546557 cites W1597610606 @default.
• W2020546557 cites W1669342624 @default.
• W2020546557 cites W1863566879 @default.
• W2020546557 cites W1881589758 @default.
• W2020546557 cites W1971298806 @default.
• W2020546557 cites W1977627834 @default.
• W2020546557 cites W1985424964 @default.
• W2020546557 cites W1991764444 @default.
• W2020546557 cites W2012960474 @default.
• W2020546557 cites W2017380929 @default.
• W2020546557 cites W2028379046 @default.
• W2020546557 cites W2046657068 @default.
• W2020546557 cites W2046660452 @default.
• W2020546557 cites W2049646727 @default.
• W2020546557 cites W2056037928 @default.
• W2020546557 cites W2063822778 @default.
• W2020546557 cites W2068395655 @default.
• W2020546557 cites W2069951758 @default.
• W2020546557 cites W2079831464 @default.
• W2020546557 cites W2086299681 @default.
• W2020546557 cites W2094537875 @default.
• W2020546557 cites W2102612806 @default.
• W2020546557 cites W2262250683 @default.
• W2020546557 cites W4296792904 @default.
• W2020546557 cites W570370693 @default.
• W2020546557 doi "https://doi.org/10.1046/j.1365-2141.2002.03723.x" @default.
• W2020546557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12139725" @default.
• W2020546557 hasPublicationYear "2002" @default.
• W2020546557 type Work @default.
• W2020546557 sameAs 2020546557 @default.
• W2020546557 citedByCount "30" @default.
• W2020546557 countsByYear W20205465572013 @default.
• W2020546557 countsByYear W20205465572014 @default.
• W2020546557 countsByYear W20205465572015 @default.
• W2020546557 countsByYear W20205465572016 @default.
• W2020546557 countsByYear W20205465572017 @default.
• W2020546557 countsByYear W20205465572018 @default.
• W2020546557 countsByYear W20205465572019 @default.
• W2020546557 countsByYear W20205465572021 @default.
• W2020546557 crossrefType "journal-article" @default.
• W2020546557 hasAuthorship W2020546557A5004230500 @default.
• W2020546557 hasAuthorship W2020546557A5006653971 @default.
• W2020546557 hasAuthorship W2020546557A5007616559 @default.
• W2020546557 hasAuthorship W2020546557A5007888883 @default.
• W2020546557 hasAuthorship W2020546557A5012652636 @default.
• W2020546557 hasAuthorship W2020546557A5013342218 @default.
• W2020546557 hasAuthorship W2020546557A5030597247 @default.
• W2020546557 hasAuthorship W2020546557A5037362999 @default.
• W2020546557 hasAuthorship W2020546557A5047706264 @default.
• W2020546557 hasAuthorship W2020546557A5079987156 @default.
• W2020546557 hasBestOaLocation W20205465571 @default.
• W2020546557 hasConcept C108634530 @default.
• W2020546557 hasConcept C109523444 @default.
• W2020546557 hasConcept C13373296 @default.
• W2020546557 hasConcept C153911025 @default.
• W2020546557 hasConcept C185592680 @default.
• W2020546557 hasConcept C203014093 @default.
• W2020546557 hasConcept C2776914184 @default.
• W2020546557 hasConcept C2779282312 @default.
• W2020546557 hasConcept C2779963572 @default.
• W2020546557 hasConcept C2781121885 @default.
• W2020546557 hasConcept C502942594 @default.
• W2020546557 hasConcept C54355233 @default.
• W2020546557 hasConcept C55493867 @default.
• W2020546557 hasConcept C81885089 @default.
• W2020546557 hasConcept C86803240 @default.
• W2020546557 hasConceptScore W2020546557C108634530 @default.
• W2020546557 hasConceptScore W2020546557C109523444 @default.
• W2020546557 hasConceptScore W2020546557C13373296 @default.
• W2020546557 hasConceptScore W2020546557C153911025 @default.
• W2020546557 hasConceptScore W2020546557C185592680 @default.
• W2020546557 hasConceptScore W2020546557C203014093 @default.
• W2020546557 hasConceptScore W2020546557C2776914184 @default.
• W2020546557 hasConceptScore W2020546557C2779282312 @default.
• W2020546557 hasConceptScore W2020546557C2779963572 @default.
• W2020546557 hasConceptScore W2020546557C2781121885 @default.
• W2020546557 hasConceptScore W2020546557C502942594 @default.
• W2020546557 hasConceptScore W2020546557C54355233 @default.
• W2020546557 hasConceptScore W2020546557C55493867 @default.
• W2020546557 hasConceptScore W2020546557C81885089 @default.

• next