Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020551149> ?p ?o ?g. }
- W2020551149 endingPage "267" @default.
- W2020551149 startingPage "241" @default.
- W2020551149 abstract "Ring-cleaving dioxygenases catalyze the oxygenolytic fission of catecholic compounds, a critical step in the aerobic degradation of aromatic compounds by bacteria. Two classes of these enzymes have been identified, based on the mode of ring cleavage: intradiol dioxygenases utilize non-heme Fe(III) to cleave the aromatic nucleus ortho to the hydroxyl substituents; and extradiol dioxygenases utilize non-heme Fe(II) or other divalent metal ions to cleave the aromatic nucleus meta to the hydroxyl substituents. Recent genomic, structural, spectroscopic, and kinetic studies have increased our understanding of the distribution, evolution, and mechanisms of these enzymes. Overall, extradiol dioxygenases appear to be more versatile than their intradiol counterparts. Thus, the former cleave a wider variety of substrates, have evolved on a larger number of structural scaffolds, and occur in a wider variety of pathways, including biosynthetic pathways and pathways that degrade non-aromatic compounds. The catalytic mechanisms of the two enzymes proceed via similar iron-alkylperoxo intermediates. The ability of extradiol enzymes to act on a variety of non-catecholic compounds is consistent with proposed differences in the breakdown of this iron-alkylperoxo intermediate in the two enzymes, involving alkenyl migration in extradiol enzymes and acyl migration in intradiol enzymes. Nevertheless, despite recent advances in our understanding of these fascinating enzymes, the major determinant of the mode of ring cleavage remains unknown." @default.
- W2020551149 created "2016-06-24" @default.
- W2020551149 creator A5002693857 @default.
- W2020551149 creator A5024006751 @default.
- W2020551149 creator A5077634475 @default.
- W2020551149 date "2006-01-01" @default.
- W2020551149 modified "2023-10-02" @default.
- W2020551149 title "The Ins and Outs of Ring-Cleaving Dioxygenases" @default.
- W2020551149 cites W1254562219 @default.
- W2020551149 cites W1480245711 @default.
- W2020551149 cites W1480600654 @default.
- W2020551149 cites W1482636423 @default.
- W2020551149 cites W1483833825 @default.
- W2020551149 cites W1492160446 @default.
- W2020551149 cites W1492352549 @default.
- W2020551149 cites W1499218235 @default.
- W2020551149 cites W1501880916 @default.
- W2020551149 cites W1503438757 @default.
- W2020551149 cites W1525234184 @default.
- W2020551149 cites W1539770653 @default.
- W2020551149 cites W1541946496 @default.
- W2020551149 cites W1545850173 @default.
- W2020551149 cites W1553529773 @default.
- W2020551149 cites W1555471713 @default.
- W2020551149 cites W1556036387 @default.
- W2020551149 cites W1556406922 @default.
- W2020551149 cites W1560205634 @default.
- W2020551149 cites W1561118044 @default.
- W2020551149 cites W1563615273 @default.
- W2020551149 cites W1574688274 @default.
- W2020551149 cites W1574880565 @default.
- W2020551149 cites W1597350167 @default.
- W2020551149 cites W1606915127 @default.
- W2020551149 cites W1609933329 @default.
- W2020551149 cites W1650854146 @default.
- W2020551149 cites W1760212501 @default.
- W2020551149 cites W1817697242 @default.
- W2020551149 cites W1836453650 @default.
- W2020551149 cites W1875450122 @default.
- W2020551149 cites W1877788388 @default.
- W2020551149 cites W1878596711 @default.
- W2020551149 cites W191645289 @default.
- W2020551149 cites W1916774099 @default.
- W2020551149 cites W1929452298 @default.
- W2020551149 cites W1939593311 @default.
- W2020551149 cites W1947079771 @default.
- W2020551149 cites W1952050064 @default.
- W2020551149 cites W1965133779 @default.
- W2020551149 cites W1965612605 @default.
- W2020551149 cites W1966267129 @default.
- W2020551149 cites W1968561681 @default.
- W2020551149 cites W1968979116 @default.
- W2020551149 cites W1969126182 @default.
- W2020551149 cites W1969717115 @default.
- W2020551149 cites W1970269905 @default.
- W2020551149 cites W1971157547 @default.
- W2020551149 cites W1972203402 @default.
- W2020551149 cites W1972434921 @default.
- W2020551149 cites W1973067651 @default.
- W2020551149 cites W1973703837 @default.
- W2020551149 cites W1973949218 @default.
- W2020551149 cites W1974284994 @default.
- W2020551149 cites W1974518253 @default.
- W2020551149 cites W1977601185 @default.
- W2020551149 cites W1977734848 @default.
- W2020551149 cites W1977905617 @default.
- W2020551149 cites W1979778649 @default.
- W2020551149 cites W1979937703 @default.
- W2020551149 cites W1980660291 @default.
- W2020551149 cites W1980737963 @default.
- W2020551149 cites W1981535049 @default.
- W2020551149 cites W1981689753 @default.
- W2020551149 cites W1983153696 @default.
- W2020551149 cites W1983848768 @default.
- W2020551149 cites W1983985990 @default.
- W2020551149 cites W1984480963 @default.
- W2020551149 cites W1984850597 @default.
- W2020551149 cites W1990439861 @default.
- W2020551149 cites W1991354940 @default.
- W2020551149 cites W1991812438 @default.
- W2020551149 cites W1992591628 @default.
- W2020551149 cites W1994701129 @default.
- W2020551149 cites W2001005544 @default.
- W2020551149 cites W2001990688 @default.
- W2020551149 cites W2003164445 @default.
- W2020551149 cites W2004161247 @default.
- W2020551149 cites W2006758553 @default.
- W2020551149 cites W2006946556 @default.
- W2020551149 cites W2008255981 @default.
- W2020551149 cites W2015767272 @default.
- W2020551149 cites W2015799632 @default.
- W2020551149 cites W2017103595 @default.
- W2020551149 cites W2018800405 @default.
- W2020551149 cites W2019086744 @default.
- W2020551149 cites W2019433730 @default.
- W2020551149 cites W2019798464 @default.
- W2020551149 cites W2021426561 @default.
- W2020551149 cites W2022745658 @default.