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• W2020551410 abstract "The diaphragm muscle (DIAm) is responsible for breathing and determines the ability to generate both ventilatory and non-ventilatory behaviors. Size limitations of the mouse make transdiaphragmatic pressure (Pdi) measurement using a dual balloon system untenable. Adult C57BL/6J mice (n = 8) and C57BL/6 × 129 (n = 9), underwent Pdi measurements using solid-state pressure catheters spanning the thoracic and abdominal surfaces of the DIAm. Measurements were conducted during eupnea, hypoxia (10% O2)–hypercapnia (5% CO2), chemical airway stimulation (i.e., sneezing), spontaneously occurring deep breaths, sustained tracheal occlusion, and bilateral phrenic nerve stimulation. There was a difference in the Pdi generated across the range of ventilatory and non-ventilatory behaviors (p = 0.001). No difference in Pdi across behaviors was evident between mouse strains (p = 0.161). This study establishes a novel method to determine Pdi across a range of DIAm behaviors in mice that may be useful in evaluating conditions associated with reduced ability to perform expulsive, non-ventilatory behaviors." @default.
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• W2020551410 date "2013-08-01" @default.
• W2020551410 modified "2023-10-15" @default.
• W2020551410 title "Novel method for transdiaphragmatic pressure measurements in mice" @default.
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• W2020551410 doi "https://doi.org/10.1016/j.resp.2013.04.018" @default.
• W2020551410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3699961" @default.
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