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• W2020554150 abstract "The blood-brain barrier (BBB) impedes the influx of intravascular compounds from the blood to the brain. The elements composing the BBB are endothelial cells, pericytes and the end-feet of astrocytes. Among them, the endothelial cell barrier line is the most critical for preventing toxic substances from entering the brain. In this review, we focus on the ultrastructural distribution of important components in the intracellular junction and cytoplasm of brain endothelial cells. The ultrastructural distribution of tight junction-specific integral membrane proteins such as occludin, junctional adhesion molecules, claudin, peripheral zonula occludens protein-1 (ZO-1), adherens junction-specific transmembrane protein cadherin, and adherens junction-associated peripheral proteins alpha-catenin, beta-catenin, and p120 catenin is reviewed. P-glycoprotein and some other transporters recently discovered in endothelial cells prevent several compounds from entering the brain parenchyma. It is likely that the transient inhibition of P-glycoprotein by antidepressants enables other medicines to enter the brain. Vesicular transport with clathrin-mediated or adsorptive endocytosis through endothelial cells is also critical for transportation of blood-born substances from the bloodstream to the brain. How medicines pass the BBB to reach the brain parenchyma is discussed." @default.
• W2020554150 created "2016-06-24" @default.
• W2020554150 creator A5069584678 @default.
• W2020554150 date "2007-05-01" @default.
• W2020554150 modified "2023-09-25" @default.
• W2020554150 title "Molecular Anatomy of the Brain Endothelial Barrier: An Overview of the Distributional Features" @default.
• W2020554150 doi "https://doi.org/10.2174/092986707780597943" @default.
• W2020554150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17504140" @default.
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