FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020556597> ?p ?o ?g. }

• W2020556597 endingPage "e1347" @default.
• W2020556597 startingPage "e1347" @default.
• W2020556597 abstract "Previous studies have shown that miR-203 is a skin-specific microRNA (miRNA) with a profound role in skin cell differentiation. However, emerging microarray and deep sequencing data revealed that miR-203 is also expressed in embryonic skeletal muscle and myoblasts. In this study, we found that miR-203 was transiently upregulated in chicken embryos on days 10 to 16 (E10-E16) and was sharply downregulated and even not expressed after E16 in chicken embryonic skeletal muscle. Histological profiles and weight variations of embryo skeletal muscle revealed that miR-203 expression is correlated with muscle development. In vitro experiments showed that miR-203 exhibited downregulated expression during myoblast differentiation into myotubes. miR-203 overexpression inhibited myoblast proliferation and differentiation, whereas its loss-of-function increased myoblast proliferation and differentiation. During myogenesis, miR-203 can target and inhibit the expression of c-JUN and MEF2C, which were important for cell proliferation and muscle development, respectively. The overexpression of c-JUN significantly promoted myoblast proliferation. Conversely, knockdown of c-JUN by siRNA suppressed myoblast proliferation. In addition, the knockdown of MEF2C by siRNA significantly inhibited myoblast differentiation. Altogether, these data not only suggested that the expression of miR-203 is transitory during chicken skeletal muscle development but also showed a novel role of miR-203 in inhibiting skeletal muscle cell proliferation and differentiation by repressing c-JUN and MEF2C, respectively." @default.
• W2020556597 created "2016-06-24" @default.
• W2020556597 creator A5006706475 @default.
• W2020556597 creator A5010899677 @default.
• W2020556597 creator A5015792001 @default.
• W2020556597 creator A5017274582 @default.
• W2020556597 creator A5020906825 @default.
• W2020556597 creator A5026543951 @default.
• W2020556597 creator A5044171041 @default.
• W2020556597 creator A5067940301 @default.
• W2020556597 creator A5071033452 @default.
• W2020556597 creator A5090650329 @default.
• W2020556597 date "2014-07-17" @default.
• W2020556597 modified "2023-10-17" @default.
• W2020556597 title "The transient expression of miR-203 and its inhibiting effects on skeletal muscle cell proliferation and differentiation" @default.
• W2020556597 cites W1970137304 @default.
• W2020556597 cites W1971977081 @default.
• W2020556597 cites W1981186391 @default.
• W2020556597 cites W1983029447 @default.
• W2020556597 cites W1986660515 @default.
• W2020556597 cites W1986903527 @default.
• W2020556597 cites W1991494214 @default.
• W2020556597 cites W1994587676 @default.
• W2020556597 cites W2003369513 @default.
• W2020556597 cites W2018082228 @default.
• W2020556597 cites W2018105329 @default.
• W2020556597 cites W2026472364 @default.
• W2020556597 cites W2026579495 @default.
• W2020556597 cites W2030551062 @default.
• W2020556597 cites W2032241627 @default.
• W2020556597 cites W2032801961 @default.
• W2020556597 cites W2040766015 @default.
• W2020556597 cites W2042016774 @default.
• W2020556597 cites W2043123806 @default.
• W2020556597 cites W2043251964 @default.
• W2020556597 cites W2057845770 @default.
• W2020556597 cites W2063156985 @default.
• W2020556597 cites W2065790963 @default.
• W2020556597 cites W2074874387 @default.
• W2020556597 cites W2076276305 @default.
• W2020556597 cites W2078422108 @default.
• W2020556597 cites W2086525709 @default.
• W2020556597 cites W2088359708 @default.
• W2020556597 cites W2089320547 @default.
• W2020556597 cites W2092018614 @default.
• W2020556597 cites W2092263801 @default.
• W2020556597 cites W2094340038 @default.
• W2020556597 cites W2107277218 @default.
• W2020556597 cites W2109567968 @default.
• W2020556597 cites W2109838780 @default.
• W2020556597 cites W2110270688 @default.
• W2020556597 cites W2112431248 @default.
• W2020556597 cites W2113194941 @default.
• W2020556597 cites W2114395071 @default.
• W2020556597 cites W2118308505 @default.
• W2020556597 cites W2119932644 @default.
• W2020556597 cites W2128160901 @default.
• W2020556597 cites W2129248963 @default.
• W2020556597 cites W2133699495 @default.
• W2020556597 cites W2138313400 @default.
• W2020556597 cites W2139056019 @default.
• W2020556597 cites W2145931730 @default.
• W2020556597 cites W2146035452 @default.
• W2020556597 cites W2150153162 @default.
• W2020556597 cites W2156125844 @default.
• W2020556597 cites W2159888101 @default.
• W2020556597 cites W2160950853 @default.
• W2020556597 cites W2163758255 @default.
• W2020556597 cites W2165697838 @default.
• W2020556597 cites W2313048860 @default.
• W2020556597 cites W4238038536 @default.
• W2020556597 cites W4248695876 @default.
• W2020556597 doi "https://doi.org/10.1038/cddis.2014.289" @default.
• W2020556597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4123083" @default.
• W2020556597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25032870" @default.
• W2020556597 hasPublicationYear "2014" @default.
• W2020556597 type Work @default.
• W2020556597 sameAs 2020556597 @default.
• W2020556597 citedByCount "77" @default.
• W2020556597 countsByYear W20205565972015 @default.
• W2020556597 countsByYear W20205565972016 @default.
• W2020556597 countsByYear W20205565972017 @default.
• W2020556597 countsByYear W20205565972018 @default.
• W2020556597 countsByYear W20205565972019 @default.
• W2020556597 countsByYear W20205565972020 @default.
• W2020556597 countsByYear W20205565972021 @default.
• W2020556597 countsByYear W20205565972022 @default.
• W2020556597 countsByYear W20205565972023 @default.
• W2020556597 crossrefType "journal-article" @default.
• W2020556597 hasAuthorship W2020556597A5006706475 @default.
• W2020556597 hasAuthorship W2020556597A5010899677 @default.
• W2020556597 hasAuthorship W2020556597A5015792001 @default.
• W2020556597 hasAuthorship W2020556597A5017274582 @default.
• W2020556597 hasAuthorship W2020556597A5020906825 @default.
• W2020556597 hasAuthorship W2020556597A5026543951 @default.
• W2020556597 hasAuthorship W2020556597A5044171041 @default.
• W2020556597 hasAuthorship W2020556597A5067940301 @default.
• W2020556597 hasAuthorship W2020556597A5071033452 @default.

• next