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- W2020561916 abstract "A series of 1,2,4-triazole derivatives containing thiosemicarbazone linkage was synthesized and evaluated for their in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. All the compounds were capable of inhibiting the growth of E. histolytica out of which four compounds (IC50 = 0.28–1.38 μM) were found to have better efficacy than the standard drug Metronidazole (IC50 = 1.8 μM). Cytotoxicity of the active compounds was assessed by MTT assay using human breast cancer MCF-7 cell line, which revealed that all the compounds were low cytotoxic in the concentration range of 2.5–250 μM." @default.
- W2020561916 created "2016-06-24" @default.
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- W2020561916 date "2012-04-01" @default.
- W2020561916 modified "2023-10-11" @default.
- W2020561916 title "Thiosemicarbazone fragment embedded within 1,2,4-triazole ring as inhibitors of Entamoeba histolytica" @default.
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- W2020561916 doi "https://doi.org/10.1016/j.bmcl.2012.02.084" @default.
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