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• W2020563663 startingPage "853" @default.
• W2020563663 abstract "There is no existing formal, long-term program for gathering evidence of the incidence and severity of the health effects of toxic substances in wildlife. However, research-based studies of bald eagles, herring gulls, night herons, tree swallows, snapping turtles, mink, and beluga over the past 30 years have revealed a broad spectrum of health effects in the Great Lakes-St. Lawrence basin including thyroid and other endocrine disorders, metabolic diseases, altered immune function, reproductive impairment, developmental toxicity, genotoxicity, and cancer. These effects occurred most often and were most severe in the most contaminated sites (Green Bay, Saginaw Bay, Lake Ontario, the St. Lawrence estuary, and more recently, Lake Erie), some of which are International Joint Commission-designated Areas of Concern (AOCs). In all cases, a strong argument can be made for an environmental etiology, and in many cases for the involvement of persistent organic pollutants, particularly polychlorinated biphenyls, polychlorinated dibenzo-(italic)p(/italic)-dioxins, and polycyclic aromatic hydrocarbons. For some, the association with particular contaminants is consistent with controlled studies, and in some, dose-response relationships were documented. The biologic significance of these health impairments to the affected species is currently unclear, but they resemble those observed with increased incidence in human subpopulations in one or more AOCs. Formalizing health effects monitoring of sentinel wildlife species by the parties to the Canada-USA Great Lakes Water Quality Agreement is required. This would facilitate the optimal use of sentinel wildlife health data in a larger, epidemiologic weight-of-evidence context upon which to base decisions and policies regarding the effects of chemical exposures on human populations." @default.
• W2020563663 created "2016-06-24" @default.
• W2020563663 creator A5068546807 @default.
• W2020563663 date "2001-12-01" @default.
• W2020563663 modified "2023-09-30" @default.
• W2020563663 title "Wildlife as sentinels of human health effects in the Great Lakes--St. Lawrence basin." @default.
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• W2020563663 doi "https://doi.org/10.1289/ehp.01109s6853" @default.
• W2020563663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1240620" @default.
• W2020563663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11744503" @default.
• W2020563663 hasPublicationYear "2001" @default.
• W2020563663 type Work @default.

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