Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020565331> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2020565331 endingPage "4135" @default.
- W2020565331 startingPage "4135" @default.
- W2020565331 abstract "Abstract Background: MDSC acumulation is an important mechanism of tumor escape from immune surveillance and cancer progression. Pre-clinical studies have shown a correlation between tumor progression and MDSC. While we and others have shown that circulating MDSC correlate with clinical stage, to date there are few clinical studies that have explored the correlation of MDSC with metastatic tumor burden or as an adverse prognostic factor. Consequently, the goal of this study was to determine whether levels of MDSC in patients with stage IV breast cancer correlate with tumor burden using CTC and Swenerton Scores (SS) as surrogates for metastatic disease burden, and if circulating MDSC levels were predictive of overall survival.Methods: Flow cytometric analysis was performed on peripheral whole blood from 25 patients with stage IV breast cancer prior to initiation of therapy and at defined intervals during therapy. The MDSC population was defined as lineage-, CD33+, HLA-DR-, CD11b+. CTC (CellSearch®) and MDSC were drawn simultaneously and SS were calculated using a standardized scoring system previously defined and published in the literature. A generalized estimating equation regression model was created and fitted individually for each predictor. OS was defined as time of study enrollment to date of death.Results: Using a generalized estimating equation regression model the percentage of MDSC in peripheral blood was found to have a close correlation with CTC (Pearson correlation 0.62, p=0.0001) and a coefficient of 0.29 (0.14, 0.43 95%CI). The correlation between percent MDSC and SS was not significant (Pearson 0.31, p=0.12). Interestingly, no significant correlation between CTC and SS was noted either. MDSC levels were also found to predict OS in patients with the highest percentages at the first visit having significantly decreased median overall survival [6.8 vs. 19.6 months; p=0.05]Similarly, high MDSC levels at the final blood draw was also found to correlate with significantly shorter median OS [p=0.023].Conclusions. MDSC correlated well with CTC but not SS. High circulating MDSC levels were associated with significantly decreased overall survival in patients with metastatic breast cancer. MDSC appear to be a promising prognostic immunologic biomarker in metastatic breast cancer. Further studies are needed to better define the role of MDSCs in breast cancer progression and may be a useful therapeutic target to enhance the effectiveness of immune based therapies in breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4135." @default.
- W2020565331 created "2016-06-24" @default.
- W2020565331 creator A5010065773 @default.
- W2020565331 creator A5024618610 @default.
- W2020565331 creator A5037258605 @default.
- W2020565331 creator A5062153423 @default.
- W2020565331 creator A5079075086 @default.
- W2020565331 creator A5088671320 @default.
- W2020565331 creator A5090206101 @default.
- W2020565331 date "2009-12-01" @default.
- W2020565331 modified "2023-10-18" @default.
- W2020565331 title "Elevated Circulating Myeloid Derived Suppressor Cells (MDSC) Are Associated with Inferior Overall Survival (OS) and Correlate with Circulating Tumor Cells (CTC) in Patients with Metastatic Breast Cancer." @default.
- W2020565331 doi "https://doi.org/10.1158/0008-5472.sabcs-09-4135" @default.
- W2020565331 hasPublicationYear "2009" @default.
- W2020565331 type Work @default.
- W2020565331 sameAs 2020565331 @default.
- W2020565331 citedByCount "16" @default.
- W2020565331 countsByYear W20205653312013 @default.
- W2020565331 countsByYear W20205653312015 @default.
- W2020565331 countsByYear W20205653312016 @default.
- W2020565331 countsByYear W20205653312017 @default.
- W2020565331 countsByYear W20205653312020 @default.
- W2020565331 countsByYear W20205653312021 @default.
- W2020565331 countsByYear W20205653312022 @default.
- W2020565331 crossrefType "journal-article" @default.
- W2020565331 hasAuthorship W2020565331A5010065773 @default.
- W2020565331 hasAuthorship W2020565331A5024618610 @default.
- W2020565331 hasAuthorship W2020565331A5037258605 @default.
- W2020565331 hasAuthorship W2020565331A5062153423 @default.
- W2020565331 hasAuthorship W2020565331A5079075086 @default.
- W2020565331 hasAuthorship W2020565331A5088671320 @default.
- W2020565331 hasAuthorship W2020565331A5090206101 @default.
- W2020565331 hasConcept C121608353 @default.
- W2020565331 hasConcept C126322002 @default.
- W2020565331 hasConcept C143998085 @default.
- W2020565331 hasConcept C179185449 @default.
- W2020565331 hasConcept C203014093 @default.
- W2020565331 hasConcept C2779013556 @default.
- W2020565331 hasConcept C2908647359 @default.
- W2020565331 hasConcept C530470458 @default.
- W2020565331 hasConcept C55721878 @default.
- W2020565331 hasConcept C61238886 @default.
- W2020565331 hasConcept C71924100 @default.
- W2020565331 hasConcept C8891405 @default.
- W2020565331 hasConcept C99454951 @default.
- W2020565331 hasConceptScore W2020565331C121608353 @default.
- W2020565331 hasConceptScore W2020565331C126322002 @default.
- W2020565331 hasConceptScore W2020565331C143998085 @default.
- W2020565331 hasConceptScore W2020565331C179185449 @default.
- W2020565331 hasConceptScore W2020565331C203014093 @default.
- W2020565331 hasConceptScore W2020565331C2779013556 @default.
- W2020565331 hasConceptScore W2020565331C2908647359 @default.
- W2020565331 hasConceptScore W2020565331C530470458 @default.
- W2020565331 hasConceptScore W2020565331C55721878 @default.
- W2020565331 hasConceptScore W2020565331C61238886 @default.
- W2020565331 hasConceptScore W2020565331C71924100 @default.
- W2020565331 hasConceptScore W2020565331C8891405 @default.
- W2020565331 hasConceptScore W2020565331C99454951 @default.
- W2020565331 hasIssue "24_Supplement" @default.
- W2020565331 hasLocation W20205653311 @default.
- W2020565331 hasOpenAccess W2020565331 @default.
- W2020565331 hasPrimaryLocation W20205653311 @default.
- W2020565331 hasRelatedWork W2144318661 @default.
- W2020565331 hasRelatedWork W2224319365 @default.
- W2020565331 hasRelatedWork W2226806579 @default.
- W2020565331 hasRelatedWork W2395906155 @default.
- W2020565331 hasRelatedWork W2979892935 @default.
- W2020565331 hasRelatedWork W3084463300 @default.
- W2020565331 hasRelatedWork W377899687 @default.
- W2020565331 hasRelatedWork W4281699676 @default.
- W2020565331 hasRelatedWork W4289745076 @default.
- W2020565331 hasRelatedWork W73860091 @default.
- W2020565331 hasVolume "69" @default.
- W2020565331 isParatext "false" @default.
- W2020565331 isRetracted "false" @default.
- W2020565331 magId "2020565331" @default.
- W2020565331 workType "article" @default.