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• W2020565415 abstract "Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle." @default.
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• W2020565415 date "2011-12-12" @default.
• W2020565415 modified "2023-10-18" @default.
• W2020565415 title "Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription" @default.
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• W2020565415 doi "https://doi.org/10.1038/srep00189" @default.
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