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- W2020567353 abstract "This study examined whether verapamil (V) can block α adrenoceptors in newborns, as reported in adults (Bou, J. et al., J. Auton. Pharmac. 3: 219-232, 1983). CV responses to the α1 agonist, phenylephrine (PE), given as an i.v. bolus (20 mcg/kg), were examined before and immediately after a 2 min i.v. infusion of 100 or 300 mcg/kg V in 28 anesthetized, 1 day and 2 week old piglets. ECG, heart rate (HR), aortic (AoP) and LV pressures, LV dP/dt max and phasic mesenteric (Mes), renal (Ren) and femoral (Fem) flows were recorded; vascular resistance (R) was calculated. PE increased mean AoP, MesR and RenR and decreased HR with no consistent changes in LV dP/dt max and FemR. In 1 day olds, there was no significant difference in CV responses to PE before and after V. In 2 week olds after high dose V, the following responses (mean % change ± SE) to PE were significantly diminished: MesR (174±58 vs 85±33; p≤0.02), RenR (246±41 vs 124±29; p≤.0.02), mean AoP (54±6 vs 38±5; p≤0.003). The smaller increase in mean AoP elicited less of a reflex bradycardia. After low dose V the PE induced increase in LV dP/dt max was augmented (13±4 vs 22±4; p≤0.04), while the increase in RenR to PE was diminished in all 2 week olds. The results indicate that the ability of V to block α1 adrenoceptors matures postnatally. This may be another manifestation of functional immaturity of α adrenoceptors at birth. The results of the present study provide a basis for understanding the age- and dose-dependent CV effects of V observed in young swine (Gootman, N. et al, Pediatr. Res. 18: 122A, 1984). Supported by Am. Heart Assoc., Nassau Chapter." @default.
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- W2020567353 date "1985-04-01" @default.
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- W2020567353 title "380 EFFECTS OF A CALCIUM ANTAGONIST ON THE CARDIOVASCULAR (CV) RESPONSES TO AN α1 ADRENOCEPTOR AGONIST IN DEVELOPING SWINE" @default.
- W2020567353 doi "https://doi.org/10.1203/00006450-198504000-00410" @default.
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