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- W2020576421 abstract "In the last few decades, the field of immunogenetics has vastly grown with tremendous developments being made to study pathogenesis, mechanisms, and pathways underlying these immunogenetic disorders because of the availability of more sophisticated diagnostic tools and techniques. In the pathological state, immune system components are predominantly altered; thus, it is easy to differentiate between defects of innate and adaptive immune systems. Defects in either of these two forms lead to the development of a group of well distinct congenital several immunodeficiency disorders, which can be life threatening and also associated with severe recurrent infections. Immunogenetic disorders may be present from birth, occur during infancy, or any stage of early life and may be life-threatening until treated with hematopoietic stem cell transplantation. An array of genetic defects are caused by defects in T cell development, which may be accompanied by defects in the development of B and NK cells. In humans, main immunogenetic diseases are severe combined immunodeficiency, X-linked agammaglobulinemia, X-linked hyper IgM syndrome, Wiskott–Aldrich syndrome and chronic granulomatous disease. It is very essential to develop immunotherapeutics to treat immune-related specific diseases. A broad range of phytocompounds obtained from various plants are easily isolated, characterized, developed, and modified for use in the treatment of human diseases. Several cytotoxic drugs and antibiotics have also been produced from phytocompounds, but the use of conventional or emerging medicinal plants as immunomodulators in the treatment of immune diseases is still rare. In this chapter, some immunogenetic disorders and the use of some medicinal herbs and isolated phytocompounds for the treatment of immune diseases are discussed." @default.
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- W2020576421 date "2000-12-01" @default.
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- W2020576421 title "A Disease Gene for Autosomal Hyper-IgM Syndrome: More Genes Associated with More Immunodeficiencies" @default.
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- W2020576421 doi "https://doi.org/10.1006/clim.2000.4973" @default.
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