Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020585057> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2020585057 abstract "The effect of natural IgG antibody recognizing β-galactosyl epitope on hepatoma cell invasion was investigated. Anti-β-galactosyl antibody dose-dependently suppressed hepatoma invasion underneath primarily cultured mesothelial cells monolayer without affecting the proliferation, to the same extent as natural IgG antibody with anti-α-galactosyl specificity, which had already been reported to have an anti-metastatic activity. The inhibitory effect of anti-β-galactosyl antibody was completely canceled by adding lactose (galactose-β-1, 4-glucose) to the medium, indicating that this antibody recognized some antigens with β-galactosyl epitope. Hepatoma cells pretreated with this antibody for 48 h showed reduced invasive activity, while the pretreatment of mesothelial cells with the antibody did not affect hepatoma cells invasion. Anti-β-galactosyl antibody also suppressed hepatoma cells adhesion to mesothelial cells monolayer. These results suggest that natural antibody with anti-β-galactosyl specificity may recognize the β-galactosyl epitope in some adhesion-related molecules on hepatoma cells, thus suppressing adhesion and invasion to mesothelial cells monolayer. These results suggest possible therapeutic uses of this antibody in the treatment of metastatic tumors." @default.
- W2020585057 created "2016-06-24" @default.
- W2020585057 creator A5005207942 @default.
- W2020585057 creator A5023712329 @default.
- W2020585057 creator A5034635575 @default.
- W2020585057 creator A5035910540 @default.
- W2020585057 creator A5047381115 @default.
- W2020585057 creator A5075102399 @default.
- W2020585057 date "2012-12-19" @default.
- W2020585057 modified "2023-10-03" @default.
- W2020585057 title "Natural IgG antibody with anti-β-galactosyl specificity suppressed hepatoma cell invasion in culture" @default.
- W2020585057 cites W1514005948 @default.
- W2020585057 cites W2007251106 @default.
- W2020585057 cites W2019356549 @default.
- W2020585057 cites W2063994982 @default.
- W2020585057 cites W2085266195 @default.
- W2020585057 cites W2094143575 @default.
- W2020585057 cites W2108895381 @default.
- W2020585057 cites W2116473125 @default.
- W2020585057 cites W2130425007 @default.
- W2020585057 cites W2138075506 @default.
- W2020585057 cites W2155008640 @default.
- W2020585057 cites W2178212446 @default.
- W2020585057 cites W4242206223 @default.
- W2020585057 cites W93044937 @default.
- W2020585057 doi "https://doi.org/10.1007/s10616-012-9523-5" @default.
- W2020585057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3853630" @default.
- W2020585057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23250635" @default.
- W2020585057 hasPublicationYear "2012" @default.
- W2020585057 type Work @default.
- W2020585057 sameAs 2020585057 @default.
- W2020585057 citedByCount "0" @default.
- W2020585057 crossrefType "journal-article" @default.
- W2020585057 hasAuthorship W2020585057A5005207942 @default.
- W2020585057 hasAuthorship W2020585057A5023712329 @default.
- W2020585057 hasAuthorship W2020585057A5034635575 @default.
- W2020585057 hasAuthorship W2020585057A5035910540 @default.
- W2020585057 hasAuthorship W2020585057A5047381115 @default.
- W2020585057 hasAuthorship W2020585057A5075102399 @default.
- W2020585057 hasBestOaLocation W20205850572 @default.
- W2020585057 hasConcept C147483822 @default.
- W2020585057 hasConcept C1491633281 @default.
- W2020585057 hasConcept C153911025 @default.
- W2020585057 hasConcept C159654299 @default.
- W2020585057 hasConcept C185592680 @default.
- W2020585057 hasConcept C195616568 @default.
- W2020585057 hasConcept C203014093 @default.
- W2020585057 hasConcept C55493867 @default.
- W2020585057 hasConcept C85789140 @default.
- W2020585057 hasConcept C86803240 @default.
- W2020585057 hasConceptScore W2020585057C147483822 @default.
- W2020585057 hasConceptScore W2020585057C1491633281 @default.
- W2020585057 hasConceptScore W2020585057C153911025 @default.
- W2020585057 hasConceptScore W2020585057C159654299 @default.
- W2020585057 hasConceptScore W2020585057C185592680 @default.
- W2020585057 hasConceptScore W2020585057C195616568 @default.
- W2020585057 hasConceptScore W2020585057C203014093 @default.
- W2020585057 hasConceptScore W2020585057C55493867 @default.
- W2020585057 hasConceptScore W2020585057C85789140 @default.
- W2020585057 hasConceptScore W2020585057C86803240 @default.
- W2020585057 hasLocation W20205850571 @default.
- W2020585057 hasLocation W20205850572 @default.
- W2020585057 hasLocation W20205850573 @default.
- W2020585057 hasLocation W20205850574 @default.
- W2020585057 hasOpenAccess W2020585057 @default.
- W2020585057 hasPrimaryLocation W20205850571 @default.
- W2020585057 hasRelatedWork W1237446364 @default.
- W2020585057 hasRelatedWork W1982129404 @default.
- W2020585057 hasRelatedWork W1986706426 @default.
- W2020585057 hasRelatedWork W1993064699 @default.
- W2020585057 hasRelatedWork W2039609199 @default.
- W2020585057 hasRelatedWork W2062684714 @default.
- W2020585057 hasRelatedWork W2062790900 @default.
- W2020585057 hasRelatedWork W2077336430 @default.
- W2020585057 hasRelatedWork W2079565358 @default.
- W2020585057 hasRelatedWork W2087374893 @default.
- W2020585057 hasRelatedWork W2096319621 @default.
- W2020585057 hasRelatedWork W2100586663 @default.
- W2020585057 hasRelatedWork W2109276918 @default.
- W2020585057 hasRelatedWork W2128427430 @default.
- W2020585057 hasRelatedWork W2155673982 @default.
- W2020585057 hasRelatedWork W2316141007 @default.
- W2020585057 hasRelatedWork W2385075628 @default.
- W2020585057 hasRelatedWork W2443772760 @default.
- W2020585057 hasRelatedWork W2597739773 @default.
- W2020585057 hasRelatedWork W3084437547 @default.
- W2020585057 isParatext "false" @default.
- W2020585057 isRetracted "false" @default.
- W2020585057 magId "2020585057" @default.
- W2020585057 workType "article" @default.