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• W2020586316 abstract "Chronic stress exposure alters the central noradrenergic neurons originating from the locus coeruleus (LC). Previously, we demonstrated that evoked increases in the firing rate of LC neurons and their release of norepinephrine are enhanced following chronic cold exposure. In the present studies, we tested the hypothesis that reduced feedback inhibition of LC neurons might underlie these alterations in LC activity by examining the effect of α2-autoreceptor stimulation on LC activity in chronically stressed rats using in vivo and in vitro single unit recordings. Given that regulators of G-protein signaling (RGS) proteins can impact the coupling of α2-autoreceptors to downstream signaling cascades, we also explored the expression of several RGS proteins following chronic stress exposure. We observed that the α2-autoreceptor-evoked inhibition of LC neurons was reduced and that the expression of RGS7 was increased following chronic stress exposure. Finally, we demonstrated that intracellular administration of RGS7 via patch clamp electrodes mimicked the stress-induced decrease in clonidine-evoked autoreceptor-mediated inhibition. These novel data provide a mechanism to explain how chronic stress-induced alterations in receptor coupling can result in changes in α2-autoreceptor control of noradrenergic function throughout the central nervous system, potentially leading to alterations in anxiety-related behaviors, and may suggest novel therapeutic targets for the treatment of mood and anxiety disorders." @default.
• W2020586316 created "2016-06-24" @default.
• W2020586316 creator A5017491269 @default.
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• W2020586316 creator A5079427642 @default.
• W2020586316 date "2008-04-25" @default.
• W2020586316 modified "2023-09-28" @default.
• W2020586316 title "Chronic cold exposure increases RGS7 expression and decreases α₂-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons" @default.
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• W2020586316 cites W1547325917 @default.
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• W2020586316 cites W1670352010 @default.
• W2020586316 cites W1858111267 @default.
• W2020586316 cites W1924384005 @default.
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• W2020586316 cites W2024503607 @default.
• W2020586316 cites W2024512909 @default.
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• W2020586316 cites W2035137260 @default.
• W2020586316 cites W2035679640 @default.
• W2020586316 cites W2036636551 @default.
• W2020586316 cites W2039016127 @default.
• W2020586316 cites W2052939249 @default.
• W2020586316 cites W2053741430 @default.
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• W2020586316 doi "https://doi.org/10.1111/j.1460-9568.2008.06208.x" @default.
• W2020586316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2879008" @default.
• W2020586316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18461718" @default.
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