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- W2020591783 abstract "Adolescent goitre is generally conceived as a special form of goitre induced by an increased hormone requirement during puberty. But goitre a t puberty is not a uniform condition. Some causes of goitre are known with certainty, such as iodine deficiency and auto-immune thyroiditis. The present material of “idiopathic” adolescent goitre consisted of 39 patients (37 females, and 2 males) aged 9 to 17 years. The patients were euthyroid and largely without symptoms except goitre. The enlargement of the glands was usually small to moderate. The glands were homogeneous, of elastic consistence and had a smooth, even surface. Cytologically the goitres were characterized by active secretory follicular epithelium and abundant colloid. The uptake of radioiodine by the thyroid varied, but was usually near or just above the upper normal limit of the normal range. The amount of radioactive hormone iodine.in the plasma was, however, not increased, but, if anything, decreased. Follow-up was not long enough t o allow any valid conclusions about the definitive prognosis of the condition. So far, half of the goitres have decreased or disappeared but several show no signs of spontaneous regression. A familial predisposition to thyroid disease was noted. The idiopathic adolescent goitre was not conceived in the present investigation as an enlargement of the gland due to compensatory hyperplasia but as a colloid goitre on the basis of unknown structural defect or functional disorder of the gland and under the influence of some obscure factor or factors released or activated a t puberty." @default.
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- W2020591783 date "1966-01-01" @default.
- W2020591783 modified "2023-09-27" @default.
- W2020591783 title "Adolescent Colloid Goitre" @default.
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- W2020591783 doi "https://doi.org/10.1111/j.1651-2227.1966.tb15208.x" @default.
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