Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020592110> ?p ?o ?g. }
- W2020592110 endingPage "263" @default.
- W2020592110 startingPage "256" @default.
- W2020592110 abstract "Genomic analysis of hepatocellular carcinoma (HCC) has been shown to provide clues about local risk factors. In the last decades, the mortality from malignant liver tumors increased sharply in Romania, where both hepatitis viruses and environmental pollutants are known to be highly prevalent. To date, HCC from this country has not been subject to molecular characterization. We analyzed a series of 48 consecutive HCC cases. Point mutations were searched in 9 nuclear genes and the mitochondrial D-loop. Oxidative stress response was monitored through measurement of gene expression (NRF2, KEAP1, SRXN1, and CES1) by qRT-PCR. An atypical mutation spectrum was observed, as more than 40% of DNA changes were oxidative stress-associated T>C or T>G lesions (T>S). These mutations affected primarily genes encoding for β-catenin and NRF2 (P<0.0001). Besides, tumors from patients born in Greater Bucharest carried TP53 mutations more frequently than others (45 vs 10%, P=0.02). Finally, a R249S mutation of TP53, well-known hallmark of aflatoxin B1 exposure, was found. Our findings indicate, therefore, that distinct mutagenic processes affect Romanian patients with HCC. Further analyses are now warranted in order to identify causal lifestyle or environmental factors." @default.
- W2020592110 created "2016-06-24" @default.
- W2020592110 creator A5001462159 @default.
- W2020592110 creator A5023690844 @default.
- W2020592110 creator A5026937938 @default.
- W2020592110 creator A5032468467 @default.
- W2020592110 creator A5054608134 @default.
- W2020592110 creator A5057854470 @default.
- W2020592110 creator A5066204596 @default.
- W2020592110 creator A5077482316 @default.
- W2020592110 creator A5078501166 @default.
- W2020592110 date "2014-04-16" @default.
- W2020592110 modified "2023-10-18" @default.
- W2020592110 title "Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome" @default.
- W2020592110 cites W145382592 @default.
- W2020592110 cites W1511778826 @default.
- W2020592110 cites W1802777489 @default.
- W2020592110 cites W1943516002 @default.
- W2020592110 cites W1964415402 @default.
- W2020592110 cites W1973189244 @default.
- W2020592110 cites W1976090955 @default.
- W2020592110 cites W1985929809 @default.
- W2020592110 cites W1996969760 @default.
- W2020592110 cites W2000307707 @default.
- W2020592110 cites W2002244547 @default.
- W2020592110 cites W2003823706 @default.
- W2020592110 cites W200508625 @default.
- W2020592110 cites W2015392958 @default.
- W2020592110 cites W2016751587 @default.
- W2020592110 cites W2021142376 @default.
- W2020592110 cites W2022369816 @default.
- W2020592110 cites W2023142763 @default.
- W2020592110 cites W2027307634 @default.
- W2020592110 cites W2030134851 @default.
- W2020592110 cites W2031025087 @default.
- W2020592110 cites W2038437697 @default.
- W2020592110 cites W2042753075 @default.
- W2020592110 cites W2046565977 @default.
- W2020592110 cites W2048874346 @default.
- W2020592110 cites W2059616586 @default.
- W2020592110 cites W2062484329 @default.
- W2020592110 cites W2065903719 @default.
- W2020592110 cites W2066431692 @default.
- W2020592110 cites W2068127752 @default.
- W2020592110 cites W2073595067 @default.
- W2020592110 cites W2076097783 @default.
- W2020592110 cites W2076618644 @default.
- W2020592110 cites W2080507806 @default.
- W2020592110 cites W2087104615 @default.
- W2020592110 cites W2087108175 @default.
- W2020592110 cites W2088429193 @default.
- W2020592110 cites W2092884146 @default.
- W2020592110 cites W2112241819 @default.
- W2020592110 cites W2126835521 @default.
- W2020592110 cites W2131553001 @default.
- W2020592110 cites W2134845256 @default.
- W2020592110 cites W2138429724 @default.
- W2020592110 cites W2138649409 @default.
- W2020592110 cites W2142930729 @default.
- W2020592110 cites W2146558971 @default.
- W2020592110 cites W2319822428 @default.
- W2020592110 cites W72723659 @default.
- W2020592110 doi "https://doi.org/10.1038/jes.2014.16" @default.
- W2020592110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24736102" @default.
- W2020592110 hasPublicationYear "2014" @default.
- W2020592110 type Work @default.
- W2020592110 sameAs 2020592110 @default.
- W2020592110 citedByCount "12" @default.
- W2020592110 countsByYear W20205921102014 @default.
- W2020592110 countsByYear W20205921102015 @default.
- W2020592110 countsByYear W20205921102016 @default.
- W2020592110 countsByYear W20205921102017 @default.
- W2020592110 countsByYear W20205921102018 @default.
- W2020592110 countsByYear W20205921102019 @default.
- W2020592110 countsByYear W20205921102021 @default.
- W2020592110 countsByYear W20205921102022 @default.
- W2020592110 countsByYear W20205921102023 @default.
- W2020592110 crossrefType "journal-article" @default.
- W2020592110 hasAuthorship W2020592110A5001462159 @default.
- W2020592110 hasAuthorship W2020592110A5023690844 @default.
- W2020592110 hasAuthorship W2020592110A5026937938 @default.
- W2020592110 hasAuthorship W2020592110A5032468467 @default.
- W2020592110 hasAuthorship W2020592110A5054608134 @default.
- W2020592110 hasAuthorship W2020592110A5057854470 @default.
- W2020592110 hasAuthorship W2020592110A5066204596 @default.
- W2020592110 hasAuthorship W2020592110A5077482316 @default.
- W2020592110 hasAuthorship W2020592110A5078501166 @default.
- W2020592110 hasBestOaLocation W20205921101 @default.
- W2020592110 hasConcept C102306862 @default.
- W2020592110 hasConcept C104317684 @default.
- W2020592110 hasConcept C114246631 @default.
- W2020592110 hasConcept C126322002 @default.
- W2020592110 hasConcept C143998085 @default.
- W2020592110 hasConcept C2776151105 @default.
- W2020592110 hasConcept C2778019345 @default.
- W2020592110 hasConcept C501734568 @default.
- W2020592110 hasConcept C502942594 @default.
- W2020592110 hasConcept C54355233 @default.