Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020594474> ?p ?o ?g. }
- W2020594474 endingPage "6530" @default.
- W2020594474 startingPage "6530" @default.
- W2020594474 abstract "Siderophores are high-affinity ferric iron chelators biosynthesised and excreted by most microorganisms that play an important role in iron acquisition. Siderophore-mediated scavenging of ferric iron from hosts contributes significantly to the virulence of pathogenic microbes. As a consequence siderophore biosynthesis is an attractive target for chemotherapeutic intervention. Two main pathways for siderophore biosynthesis exist in microbes. One pathway involves nonribosomal peptide synthetase (NRPS) multienzymes while the other is NRPS-independent. The enzymology of NRPS-mediated siderophore biosynthesis has been extensively studied for more than a decade. In contrast, the enzymology of NRPS-independent siderophore (NIS) biosynthesis was overlooked for almost thirty years since the first genetic characterisation of the NIS biosynthetic pathway to aerobactin. However, the past three years have witnessed an explosion of interest in the enzymology of NIS synthetases, the key enzymes in the assembly of siderophores via the NIS pathway. The biochemical characterisation of ten purified recombinant synthetases has been reported since 2007, along with the first structural characterisation of a synthetase by X-ray crystallography in 2009. In this feature article we summarise the recent progress that has been made in understanding the long-overlooked enzymology of NRPS-independent siderophore biosynthesis, highlight important remaining questions, and suggest likely directions for future research." @default.
- W2020594474 created "2016-06-24" @default.
- W2020594474 creator A5007185815 @default.
- W2020594474 creator A5081433436 @default.
- W2020594474 creator A5091137505 @default.
- W2020594474 date "2009-01-01" @default.
- W2020594474 modified "2023-10-11" @default.
- W2020594474 title "The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis" @default.
- W2020594474 cites W1485153163 @default.
- W2020594474 cites W1486677428 @default.
- W2020594474 cites W1521221219 @default.
- W2020594474 cites W1548845294 @default.
- W2020594474 cites W1568912715 @default.
- W2020594474 cites W1669205909 @default.
- W2020594474 cites W1702657855 @default.
- W2020594474 cites W1715843563 @default.
- W2020594474 cites W1821933068 @default.
- W2020594474 cites W1884751158 @default.
- W2020594474 cites W1899866601 @default.
- W2020594474 cites W1923637231 @default.
- W2020594474 cites W1970654416 @default.
- W2020594474 cites W1974935234 @default.
- W2020594474 cites W1977813101 @default.
- W2020594474 cites W1983573316 @default.
- W2020594474 cites W198416653 @default.
- W2020594474 cites W1985529358 @default.
- W2020594474 cites W1989656537 @default.
- W2020594474 cites W1996553642 @default.
- W2020594474 cites W1997543089 @default.
- W2020594474 cites W1997867228 @default.
- W2020594474 cites W1998344636 @default.
- W2020594474 cites W1998514373 @default.
- W2020594474 cites W1999977715 @default.
- W2020594474 cites W2000707384 @default.
- W2020594474 cites W2001236306 @default.
- W2020594474 cites W2001882067 @default.
- W2020594474 cites W2008343440 @default.
- W2020594474 cites W2017492530 @default.
- W2020594474 cites W2021497905 @default.
- W2020594474 cites W2021726641 @default.
- W2020594474 cites W2022017052 @default.
- W2020594474 cites W2023229596 @default.
- W2020594474 cites W2028207395 @default.
- W2020594474 cites W2028552033 @default.
- W2020594474 cites W2031119187 @default.
- W2020594474 cites W2031458021 @default.
- W2020594474 cites W2032106045 @default.
- W2020594474 cites W2032417059 @default.
- W2020594474 cites W2034280081 @default.
- W2020594474 cites W2036124167 @default.
- W2020594474 cites W2038949613 @default.
- W2020594474 cites W2040783083 @default.
- W2020594474 cites W2041606982 @default.
- W2020594474 cites W2041755598 @default.
- W2020594474 cites W2042934444 @default.
- W2020594474 cites W2044697909 @default.
- W2020594474 cites W2050072762 @default.
- W2020594474 cites W2050298940 @default.
- W2020594474 cites W2059301909 @default.
- W2020594474 cites W2060215839 @default.
- W2020594474 cites W2061499749 @default.
- W2020594474 cites W2061705804 @default.
- W2020594474 cites W2067356508 @default.
- W2020594474 cites W2070137334 @default.
- W2020594474 cites W2070705436 @default.
- W2020594474 cites W207759834 @default.
- W2020594474 cites W2081256428 @default.
- W2020594474 cites W2085067433 @default.
- W2020594474 cites W2087327762 @default.
- W2020594474 cites W2088167775 @default.
- W2020594474 cites W2092746448 @default.
- W2020594474 cites W2093199399 @default.
- W2020594474 cites W2095759643 @default.
- W2020594474 cites W2096388077 @default.
- W2020594474 cites W2105950929 @default.
- W2020594474 cites W2106023343 @default.
- W2020594474 cites W2111507859 @default.
- W2020594474 cites W2116550876 @default.
- W2020594474 cites W2118822063 @default.
- W2020594474 cites W2119036625 @default.
- W2020594474 cites W2119366843 @default.
- W2020594474 cites W2123595241 @default.
- W2020594474 cites W2126061614 @default.
- W2020594474 cites W2127304974 @default.
- W2020594474 cites W2128022667 @default.
- W2020594474 cites W2130225062 @default.
- W2020594474 cites W2132046178 @default.
- W2020594474 cites W2135261487 @default.
- W2020594474 cites W2136369914 @default.
- W2020594474 cites W2137631963 @default.
- W2020594474 cites W2139040250 @default.
- W2020594474 cites W2144146027 @default.
- W2020594474 cites W2153390332 @default.
- W2020594474 cites W2155655994 @default.
- W2020594474 cites W2158068445 @default.
- W2020594474 cites W2159923211 @default.
- W2020594474 cites W2164712572 @default.
- W2020594474 cites W2165321946 @default.