Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020595624> ?p ?o ?g. }
- W2020595624 endingPage "1652" @default.
- W2020595624 startingPage "1647" @default.
- W2020595624 abstract "The presence of microchimerism in transplanted tissues is well defined; however, the timeframe of appearance and disappearance of engraftment in liver allograft is unknown. The aims of this study were to analyze for the presence of recipient-derived cells in sex-mismatched individuals after liver transplantation, comparing the frequency of recipient-derived cell repopulation in early versus late transplant biopsies and to evaluate the relationship between recipient-derived cell repopulation and the severity of graft injury.Paraffin-embedded liver biopsy samples of 18 recipients were reviewed. Sixteen of them were obtained from recipients with sex-mismatched donors. The remaining two were obtained from recipients with sex-matched donors and were used as controls. Immunohistochemistry and fluorescence in situ hybridization double-labeling method were performed on pretreated slides using anti-human hepatocyte antibody to identify hepatocytes, a mouse anti-human cytokeratin-7 to identify ductal epithelial cells, and using CEPX/Y DNA probes for visualizing X and Y chromosomes. The double-labeled slides were examined systematically using an image analyzer system.The mean time from transplantation to biopsy was 8.1 months. Eleven of the 16 samples obtained from recipients with sex-mismatched grafts demonstrated recipient-derived hepatocyte repopulation, comprising a mean of 2.1% of the hepatocytes. In the control biopsies, none of the cells demonstrated different nuclear signals from the donor's sex origin. The presence and proportion of recipient-derived hepatocyte repopulation rate were significantly higher in early transplant biopsies than in late transplant biopsies (P < 0.05).Some hepatocytes of sex-mismatched liver grafts were replaced by recipient-derived cells during injury. Such repopulation is more common in the early liver-graft biopsies. The severity of acute cellular rejection appears to have no effect on the rate of recipient-derived repopulation." @default.
- W2020595624 created "2016-06-24" @default.
- W2020595624 creator A5017559121 @default.
- W2020595624 creator A5025957949 @default.
- W2020595624 creator A5028204096 @default.
- W2020595624 creator A5030413648 @default.
- W2020595624 creator A5035630604 @default.
- W2020595624 creator A5038204743 @default.
- W2020595624 creator A5038906875 @default.
- W2020595624 creator A5040613529 @default.
- W2020595624 creator A5055154636 @default.
- W2020595624 creator A5061283783 @default.
- W2020595624 creator A5083057475 @default.
- W2020595624 creator A5085605553 @default.
- W2020595624 date "2004-12-15" @default.
- W2020595624 modified "2023-10-15" @default.
- W2020595624 title "Recipient-Derived Hepatocytes in Sex-Mismatched Liver Allografts after Liver Transplantation: Early versus Late Transplant Biopsies" @default.
- W2020595624 cites W1585321597 @default.
- W2020595624 cites W1964720896 @default.
- W2020595624 cites W1968110756 @default.
- W2020595624 cites W1977154080 @default.
- W2020595624 cites W1982022033 @default.
- W2020595624 cites W1986826310 @default.
- W2020595624 cites W1991248271 @default.
- W2020595624 cites W1991374176 @default.
- W2020595624 cites W2016823790 @default.
- W2020595624 cites W2024009425 @default.
- W2020595624 cites W2024241565 @default.
- W2020595624 cites W2025875442 @default.
- W2020595624 cites W2059066863 @default.
- W2020595624 cites W2062290953 @default.
- W2020595624 cites W2075009901 @default.
- W2020595624 cites W2089154676 @default.
- W2020595624 cites W2127203000 @default.
- W2020595624 cites W2142207476 @default.
- W2020595624 cites W2163721979 @default.
- W2020595624 cites W2770334239 @default.
- W2020595624 doi "https://doi.org/10.1097/01.tp.0000144055.78462.4f" @default.
- W2020595624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15591954" @default.
- W2020595624 hasPublicationYear "2004" @default.
- W2020595624 type Work @default.
- W2020595624 sameAs 2020595624 @default.
- W2020595624 citedByCount "27" @default.
- W2020595624 countsByYear W20205956242013 @default.
- W2020595624 countsByYear W20205956242014 @default.
- W2020595624 countsByYear W20205956242015 @default.
- W2020595624 countsByYear W20205956242016 @default.
- W2020595624 countsByYear W20205956242019 @default.
- W2020595624 countsByYear W20205956242020 @default.
- W2020595624 crossrefType "journal-article" @default.
- W2020595624 hasAuthorship W2020595624A5017559121 @default.
- W2020595624 hasAuthorship W2020595624A5025957949 @default.
- W2020595624 hasAuthorship W2020595624A5028204096 @default.
- W2020595624 hasAuthorship W2020595624A5030413648 @default.
- W2020595624 hasAuthorship W2020595624A5035630604 @default.
- W2020595624 hasAuthorship W2020595624A5038204743 @default.
- W2020595624 hasAuthorship W2020595624A5038906875 @default.
- W2020595624 hasAuthorship W2020595624A5040613529 @default.
- W2020595624 hasAuthorship W2020595624A5055154636 @default.
- W2020595624 hasAuthorship W2020595624A5061283783 @default.
- W2020595624 hasAuthorship W2020595624A5083057475 @default.
- W2020595624 hasAuthorship W2020595624A5085605553 @default.
- W2020595624 hasConcept C126322002 @default.
- W2020595624 hasConcept C142724271 @default.
- W2020595624 hasConcept C162834538 @default.
- W2020595624 hasConcept C16685009 @default.
- W2020595624 hasConcept C172680121 @default.
- W2020595624 hasConcept C202751555 @default.
- W2020595624 hasConcept C204232928 @default.
- W2020595624 hasConcept C2775934546 @default.
- W2020595624 hasConcept C2776200302 @default.
- W2020595624 hasConcept C2777766500 @default.
- W2020595624 hasConcept C2779234561 @default.
- W2020595624 hasConcept C2779609443 @default.
- W2020595624 hasConcept C2911091166 @default.
- W2020595624 hasConcept C54355233 @default.
- W2020595624 hasConcept C55493867 @default.
- W2020595624 hasConcept C71924100 @default.
- W2020595624 hasConcept C86803240 @default.
- W2020595624 hasConceptScore W2020595624C126322002 @default.
- W2020595624 hasConceptScore W2020595624C142724271 @default.
- W2020595624 hasConceptScore W2020595624C162834538 @default.
- W2020595624 hasConceptScore W2020595624C16685009 @default.
- W2020595624 hasConceptScore W2020595624C172680121 @default.
- W2020595624 hasConceptScore W2020595624C202751555 @default.
- W2020595624 hasConceptScore W2020595624C204232928 @default.
- W2020595624 hasConceptScore W2020595624C2775934546 @default.
- W2020595624 hasConceptScore W2020595624C2776200302 @default.
- W2020595624 hasConceptScore W2020595624C2777766500 @default.
- W2020595624 hasConceptScore W2020595624C2779234561 @default.
- W2020595624 hasConceptScore W2020595624C2779609443 @default.
- W2020595624 hasConceptScore W2020595624C2911091166 @default.
- W2020595624 hasConceptScore W2020595624C54355233 @default.
- W2020595624 hasConceptScore W2020595624C55493867 @default.
- W2020595624 hasConceptScore W2020595624C71924100 @default.
- W2020595624 hasConceptScore W2020595624C86803240 @default.
- W2020595624 hasIssue "11" @default.
- W2020595624 hasLocation W20205956241 @default.