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• W2020598013 abstract "En los últimos años, el trastorno por déficit de atención e hiperactividad (TDAH) se ha convertido en el trastorno psiquiátrico más frecuentemente diagnosticado y tratado en población pediátrica. En los años 80 fue aprobado en España el metilfenidato (MFD), un fármaco psicoestimulante, para el tratamiento sintomático del TDAH. Desde entonces, se ha convertido en uno de los medicamentos más ampliamente estudiado y prescrito tanto en niños como en adultos. En este artículo se revisan los principios farmacológicos del MFD especialmente su farmacocinética en matrices biológicas convencionales (sangre, orina) y no convencionales (cabello, saliva y sudor), preparados farmacéuticos, concentraciones terapéuticas y efectos indeseables. Attention-deficit hyperactivity disorder (ADHD) has emerged in the last few years as the most commonly diagnosed and treated psychiatric disorder in the paediatric population. In 1980's, methylphenidate (MFD) a psychomotor stimulant drug, was approved in Spain for the symptomatic therapy of ADHD. Since then, MFD has become one of the most extensively prescribed and studied treatment for ADHD both in children and adults. In this paper, the main pharmacological issues of MFD are reviewed, focusing on its pharmacokinetics in conventional (blood and urine) and non-conventional (hair, oral fluid and sweat) biological matrices, its pharmaceutical preparations, therapeutic levels and side effects." @default.
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• W2020598013 date "2013-02-01" @default.
• W2020598013 modified "2023-09-27" @default.
• W2020598013 title "Metilfenidato en el tratamiento del trastorno de déficit de atención con hiperactividad en pediatría: monitorización en matrices biológicas" @default.
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• W2020598013 doi "https://doi.org/10.1016/j.anpedi.2012.08.015" @default.
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