FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020607029> ?p ?o ?g. }

• W2020607029 endingPage "264" @default.
• W2020607029 startingPage "258" @default.
• W2020607029 abstract "The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety and efficacy assessment. The present study investigated feasibility of a 3D human airway epithelial model to study respiratory absorption, in particular to differentiate between low and high absorption of substances. Bronchial epithelial models (MucilAir™), cultured at the air–liquid interface, were exposed to eight radiolabeled model substances via the apical epithelial surface. Absorption was evaluated by measuring radioactivity in the apical compartment, the epithelial cells and the basolateral culture medium. Antipyrine, caffeine, naproxen and propranolol were highly transported across the epithelial cell layer (>5%), whereas atenolol, mannitol, PEG-400 and insulin were limitedly transported (<5%). Results indicate that the 3D human airway epithelial model used in this study is able to differentiate between substances with low and high absorption. The intra-experimental reproducibility of the results was considered adequate based on an average coefficient of variation (CV) of 15%. The inter-experimental reproducibility of highly absorbed compounds was in a similar range (CV of 15%), but this value was considerably higher for those compounds that were limitedly absorbed. No statistical significant differences between different donors and experiments were observed. The present study provides a simple method transposable in any lab, which can be used to rank the absorption of chemicals and pharmaceuticals, and is ready for further validation with respect to reproducibility and capacity of the method to predict respiratory transport in humans." @default.
• W2020607029 created "2016-06-24" @default.
• W2020607029 creator A5011840578 @default.
• W2020607029 creator A5022939303 @default.
• W2020607029 creator A5029945170 @default.
• W2020607029 creator A5047889294 @default.
• W2020607029 creator A5056523151 @default.
• W2020607029 creator A5065332769 @default.
• W2020607029 creator A5081174471 @default.
• W2020607029 date "2014-03-01" @default.
• W2020607029 modified "2023-10-18" @default.
• W2020607029 title "Feasibility of a 3D human airway epithelial model to study respiratory absorption" @default.
• W2020607029 cites W11829256 @default.
• W2020607029 cites W1596837460 @default.
• W2020607029 cites W1843865732 @default.
• W2020607029 cites W1967105417 @default.
• W2020607029 cites W1970386148 @default.
• W2020607029 cites W1975872618 @default.
• W2020607029 cites W1995273614 @default.
• W2020607029 cites W1997337049 @default.
• W2020607029 cites W2005073389 @default.
• W2020607029 cites W2007286485 @default.
• W2020607029 cites W2026204423 @default.
• W2020607029 cites W2028210174 @default.
• W2020607029 cites W2030102438 @default.
• W2020607029 cites W2037625381 @default.
• W2020607029 cites W2044162856 @default.
• W2020607029 cites W2046719626 @default.
• W2020607029 cites W2055215713 @default.
• W2020607029 cites W2057626594 @default.
• W2020607029 cites W2076931244 @default.
• W2020607029 cites W2080445885 @default.
• W2020607029 cites W2097695518 @default.
• W2020607029 cites W2120040890 @default.
• W2020607029 cites W2120166044 @default.
• W2020607029 cites W2125760551 @default.
• W2020607029 cites W2141478736 @default.
• W2020607029 cites W2145454135 @default.
• W2020607029 cites W2146654427 @default.
• W2020607029 cites W2158157119 @default.
• W2020607029 cites W2161559362 @default.
• W2020607029 cites W2164988806 @default.
• W2020607029 cites W2419098194 @default.
• W2020607029 doi "https://doi.org/10.1016/j.tiv.2013.10.025" @default.
• W2020607029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24216300" @default.
• W2020607029 hasPublicationYear "2014" @default.
• W2020607029 type Work @default.
• W2020607029 sameAs 2020607029 @default.
• W2020607029 citedByCount "29" @default.
• W2020607029 countsByYear W20206070292015 @default.
• W2020607029 countsByYear W20206070292016 @default.
• W2020607029 countsByYear W20206070292017 @default.
• W2020607029 countsByYear W20206070292018 @default.
• W2020607029 countsByYear W20206070292019 @default.
• W2020607029 countsByYear W20206070292020 @default.
• W2020607029 countsByYear W20206070292021 @default.
• W2020607029 countsByYear W20206070292022 @default.
• W2020607029 countsByYear W20206070292023 @default.
• W2020607029 crossrefType "journal-article" @default.
• W2020607029 hasAuthorship W2020607029A5011840578 @default.
• W2020607029 hasAuthorship W2020607029A5022939303 @default.
• W2020607029 hasAuthorship W2020607029A5029945170 @default.
• W2020607029 hasAuthorship W2020607029A5047889294 @default.
• W2020607029 hasAuthorship W2020607029A5056523151 @default.
• W2020607029 hasAuthorship W2020607029A5065332769 @default.
• W2020607029 hasAuthorship W2020607029A5081174471 @default.
• W2020607029 hasConcept C105702510 @default.
• W2020607029 hasConcept C125287762 @default.
• W2020607029 hasConcept C159985019 @default.
• W2020607029 hasConcept C185592680 @default.
• W2020607029 hasConcept C192562407 @default.
• W2020607029 hasConcept C2778445172 @default.
• W2020607029 hasConcept C43617362 @default.
• W2020607029 hasConcept C534529494 @default.
• W2020607029 hasConcept C55493867 @default.
• W2020607029 hasConcept C86803240 @default.
• W2020607029 hasConcept C9893847 @default.
• W2020607029 hasConceptScore W2020607029C105702510 @default.
• W2020607029 hasConceptScore W2020607029C125287762 @default.
• W2020607029 hasConceptScore W2020607029C159985019 @default.
• W2020607029 hasConceptScore W2020607029C185592680 @default.
• W2020607029 hasConceptScore W2020607029C192562407 @default.
• W2020607029 hasConceptScore W2020607029C2778445172 @default.
• W2020607029 hasConceptScore W2020607029C43617362 @default.
• W2020607029 hasConceptScore W2020607029C534529494 @default.
• W2020607029 hasConceptScore W2020607029C55493867 @default.
• W2020607029 hasConceptScore W2020607029C86803240 @default.
• W2020607029 hasConceptScore W2020607029C9893847 @default.
• W2020607029 hasIssue "2" @default.
• W2020607029 hasLocation W20206070291 @default.
• W2020607029 hasLocation W20206070292 @default.
• W2020607029 hasOpenAccess W2020607029 @default.
• W2020607029 hasPrimaryLocation W20206070291 @default.
• W2020607029 hasRelatedWork W1871281899 @default.
• W2020607029 hasRelatedWork W1963794703 @default.
• W2020607029 hasRelatedWork W1986622116 @default.
• W2020607029 hasRelatedWork W2059874727 @default.
• W2020607029 hasRelatedWork W2082129587 @default.

• next