FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020618744> ?p ?o ?g. }

• W2020618744 endingPage "e84392" @default.
• W2020618744 startingPage "e84392" @default.
• W2020618744 abstract "HRES-1/Rab4 is a small GTPase that regulates endocytic recycling. It has been colocalized to mitochondria and the mechanistic target of rapamycin (mTOR), a suppressor of autophagy. Since the autophagosomal membrane component microtubule-associated protein light chain 3 (LC3) is derived from mitochondria, we investigated the impact of HRES-1/Rab4 on the formation of LC3+ autophagosomes, their colocalization with HRES-1/Rab4 and mitochondria, and the retention of mitochondria during autophagy induced by starvation and rapamycin. HRES-1/Rab4 exhibited minimal baseline colocalization with LC3, which was enhanced 22-fold upon starvation or 6-fold upon rapamycin treatment. Colocalization of HRES-1/Rab4 with mitochondria was increased >2-fold by starvation or rapamycin. HRES-1/Rab4 overexpression promoted the colocalization of mitochondria with LC3 upon starvation or rapamycin treatment. A dominant-negative mutant, HRES-1/Rab4S27N had reduced colocalization with LC3 and mitochondria upon starvation but not rapamycin treatment. A constitutively active mutant, HRES-1/Rab4Q72L showed diminished colocalization with LC3 but promoted the partitioning of mitochondria with LC3 upon starvation or rapamycin treatment. Phosphorylation-resistant mutant HRES-1/Rab4S204Q showed diminished colocalization with LC3 but increased partitioning to mitochondria. A newly discovered C-terminally truncated native isoform, HRES-1/Rab41–121, showed enhanced localization to LC3 and mitochondria without starvation or rapamycin treatment. HRES-1/Rab41–121 increased the formation of LC3+ autophagosomes in resting cells, while other isoforms promoted autophagosome formation upon starvation. HRES-1/Rab4, HRES-1/Rab41–121, HRES-1/Rab4Q72L and HRES-1/Rab4S204Q promoted the accumulation of mitochondria during starvation. The specificity of HRES-1/Rab4-mediated mitochondrial accumulation is indicated by its abrogation by dominant-negative HRES-1/Rab4S27N mutation. The formation of interconnected mitochondrial tubular networks was markedly enhanced by HRES-1/Rab4Q72L upon starvation, which may contribute to the retention of mitochondria during autophagy. The present study thus indicates that HRES-1/Rab4 regulates autophagy through promoting the formation of LC3+ autophagosomes and the preservation of mitochondria." @default.
• W2020618744 created "2016-06-24" @default.
• W2020618744 creator A5007009197 @default.
• W2020618744 creator A5016169688 @default.
• W2020618744 creator A5019392752 @default.
• W2020618744 creator A5025875593 @default.
• W2020618744 creator A5052080448 @default.
• W2020618744 creator A5052898943 @default.
• W2020618744 creator A5060028352 @default.
• W2020618744 creator A5061848370 @default.
• W2020618744 date "2014-01-03" @default.
• W2020618744 modified "2023-10-16" @default.
• W2020618744 title "HRES-1/Rab4 Promotes the Formation of LC3+ Autophagosomes and the Accumulation of Mitochondria during Autophagy" @default.
• W2020618744 cites W1930205043 @default.
• W2020618744 cites W1965841021 @default.
• W2020618744 cites W1978397479 @default.
• W2020618744 cites W1988626677 @default.
• W2020618744 cites W1994823455 @default.
• W2020618744 cites W2000219934 @default.
• W2020618744 cites W2007980848 @default.
• W2020618744 cites W2015010210 @default.
• W2020618744 cites W2015173256 @default.
• W2020618744 cites W2016915697 @default.
• W2020618744 cites W2025176940 @default.
• W2020618744 cites W2028536701 @default.
• W2020618744 cites W2031092480 @default.
• W2020618744 cites W2037064466 @default.
• W2020618744 cites W2037703797 @default.
• W2020618744 cites W2040539483 @default.
• W2020618744 cites W2052470191 @default.
• W2020618744 cites W2052813352 @default.
• W2020618744 cites W2064273240 @default.
• W2020618744 cites W2065378127 @default.
• W2020618744 cites W2067168686 @default.
• W2020618744 cites W2078472057 @default.
• W2020618744 cites W2079416223 @default.
• W2020618744 cites W2085258486 @default.
• W2020618744 cites W2087098731 @default.
• W2020618744 cites W2105848430 @default.
• W2020618744 cites W2107429225 @default.
• W2020618744 cites W2113516691 @default.
• W2020618744 cites W2114847797 @default.
• W2020618744 cites W2124644922 @default.
• W2020618744 cites W2132763961 @default.
• W2020618744 cites W2142044474 @default.
• W2020618744 cites W2144444784 @default.
• W2020618744 cites W2147354728 @default.
• W2020618744 cites W2150273748 @default.
• W2020618744 cites W2152148024 @default.
• W2020618744 cites W2162352067 @default.
• W2020618744 cites W2162966650 @default.
• W2020618744 cites W2165213844 @default.
• W2020618744 cites W4248904091 @default.
• W2020618744 doi "https://doi.org/10.1371/journal.pone.0084392" @default.
• W2020618744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3880286" @default.
• W2020618744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24404161" @default.
• W2020618744 hasPublicationYear "2014" @default.
• W2020618744 type Work @default.
• W2020618744 sameAs 2020618744 @default.
• W2020618744 citedByCount "41" @default.
• W2020618744 countsByYear W20206187442014 @default.
• W2020618744 countsByYear W20206187442015 @default.
• W2020618744 countsByYear W20206187442016 @default.
• W2020618744 countsByYear W20206187442017 @default.
• W2020618744 countsByYear W20206187442018 @default.
• W2020618744 countsByYear W20206187442019 @default.
• W2020618744 countsByYear W20206187442020 @default.
• W2020618744 countsByYear W20206187442021 @default.
• W2020618744 countsByYear W20206187442022 @default.
• W2020618744 countsByYear W20206187442023 @default.
• W2020618744 crossrefType "journal-article" @default.
• W2020618744 hasAuthorship W2020618744A5007009197 @default.
• W2020618744 hasAuthorship W2020618744A5016169688 @default.
• W2020618744 hasAuthorship W2020618744A5019392752 @default.
• W2020618744 hasAuthorship W2020618744A5025875593 @default.
• W2020618744 hasAuthorship W2020618744A5052080448 @default.
• W2020618744 hasAuthorship W2020618744A5052898943 @default.
• W2020618744 hasAuthorship W2020618744A5060028352 @default.
• W2020618744 hasAuthorship W2020618744A5061848370 @default.
• W2020618744 hasBestOaLocation W20206187441 @default.
• W2020618744 hasConcept C190283241 @default.
• W2020618744 hasConcept C203522944 @default.
• W2020618744 hasConcept C28859421 @default.
• W2020618744 hasConcept C2909523446 @default.
• W2020618744 hasConcept C40209533 @default.
• W2020618744 hasConcept C55493867 @default.
• W2020618744 hasConcept C62478195 @default.
• W2020618744 hasConcept C86803240 @default.
• W2020618744 hasConcept C95444343 @default.
• W2020618744 hasConceptScore W2020618744C190283241 @default.
• W2020618744 hasConceptScore W2020618744C203522944 @default.
• W2020618744 hasConceptScore W2020618744C28859421 @default.
• W2020618744 hasConceptScore W2020618744C2909523446 @default.
• W2020618744 hasConceptScore W2020618744C40209533 @default.
• W2020618744 hasConceptScore W2020618744C55493867 @default.
• W2020618744 hasConceptScore W2020618744C62478195 @default.
• W2020618744 hasConceptScore W2020618744C86803240 @default.
• W2020618744 hasConceptScore W2020618744C95444343 @default.

• next