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- W2020625024 abstract "1.1. The inhibitory effects of ouabain on oxygen consumption, K+ uptake and Na+ extrusion by renal cortical slices of ground squirrels and hamsters were determined.2.2. The maximum inhibition of K+ uptake at 38° in slices of kidney cortex of ground squirrel which had been leached of K+ occurred in 25 μM ouabain. Inhibition was actually less in higher concentrations of ouabain.3.3. The reduction of respiration at 38° due to ouabain was parallel to the inhibition of K+ uptake. The uninhibited respiration was 18.0 μl O2/mg dry wt./h and the minimal O2 uptake was 11.9 in 25 μM ouabain. Extrusion of Na+ was inhibited by ouabain in a manner parallel to that of K+ uptake, but in 25 μM ouabain about half the normal extrusion of Na+ occurred.4.4. At 5° the sensitivity of ground squirrel kidneys to ouabain was less, so that 25 μM ouabain caused only slight inhibition and 3125 μM was required for maximal inhibition of K+ uptake, of respiration and of Na+ extrusion. There was greater total inhibition of Na+ extrusion by ouabain at the lower temperature than at 38°.5.5. The reduced sensitivity at low temperature was apparently due to reduced attachment or access of inhibitor to its active site. When slices were pretreated in low concentration of ouabain (25 μM) at 38° they were completely inhibited at 5° with or without additional inhibitor.6.6. The inhibition due to ouabain at 38° cannot be readily reversed by washing.7.7. Hamster kidney cortex was relatively insensitive to ouabain. In 25 μM ouabain at 38° there was negligible inhibition of K+ uptake and a concentration of 3125 μM was required for a maximal effect." @default.
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- W2020625024 date "1968-12-01" @default.
- W2020625024 modified "2023-09-27" @default.
- W2020625024 title "Ouabain inhibition of ion transport and respiration in renal cortical slices of ground squirrels and hamsters" @default.
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- W2020625024 doi "https://doi.org/10.1016/0005-2736(68)90080-1" @default.
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